Bacterial overgrowth syndrome in adolescents with Сhronic viral hepatitis C
There is a close relationship between intestine and liver, so-called ‘gut liver’ axis, especially in patients suffered from chronic liver diseases with significant degree of fibrosis. Small intestinal bacterial overgrowth and disturbance in the microbiota composition lead to an increase in the perme...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2021-04-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/566 |
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| author | N. D. Venclovaite L. G. Goryacheva V. A. Greshnyakova N. A. Efremova I. V. Shilova |
| author_facet | N. D. Venclovaite L. G. Goryacheva V. A. Greshnyakova N. A. Efremova I. V. Shilova |
| author_sort | N. D. Venclovaite |
| collection | DOAJ |
| description | There is a close relationship between intestine and liver, so-called ‘gut liver’ axis, especially in patients suffered from chronic liver diseases with significant degree of fibrosis. Small intestinal bacterial overgrowth and disturbance in the microbiota composition lead to an increase in the permeability of the intestinal epithelium, the development of endotoxinemia, the activation of pro-inflammatory cytokines and, as a consequence, an additional damage to hepatocytes.Objective. To estimate the incidence of bacterial overgrowth syndrome (BOS) in the small intestine in adolescents with chronic hepatitis C (CHC), to identify the interaction between this syndrome and cytolytic activity, the degree of fibrosis.Materials and methods. There is a group of 33 patients aged 12—17 years old with CHC. All children underwent a hydrogen breath test with lactulose. The degree of fibrosis was assessed by the results of liver elastography (Fibroscan), cytolytic activity was determined by the level of alanine transaminase in serum.Results. The frequency of BOS was 81.8% in the study group. As a result of the correlation analysis, no relationship was found between the development of BOS and the degree of cytolytic activity of chronic hepatitis C (criterion χ2= 0.914, p > 0.05). Also, there was no correlation between excessive bacterial contamination and the degree of fibrosis in the liver tissue (criterion χ2= 0.914,p> 0.05).Conclusion. BOS in children with CHC occurs much more often than in adults. However, no relationship was found between this syndrome and the severity of cytolytic activity, the degree of fibrotic changes in the liver. |
| first_indexed | 2024-04-10T03:24:26Z |
| format | Article |
| id | doaj.art-857b4eb7dbf94643966e33383c7e4226 |
| institution | Directory Open Access Journal |
| issn | 2072-8107 |
| language | Russian |
| last_indexed | 2024-04-10T03:24:26Z |
| publishDate | 2021-04-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj.art-857b4eb7dbf94643966e33383c7e42262023-03-13T07:28:26ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072021-04-01201192210.22627/2072-8107-2021-20-1-19-22483Bacterial overgrowth syndrome in adolescents with Сhronic viral hepatitis CN. D. Venclovaite0L. G. Goryacheva1V. A. Greshnyakova2N. A. Efremova3I. V. Shilova4Детский научно-клинический центр инфекционных болезнейДетский научно-клинический центр инфекционных болезней; Санкт-Петербургский государственный педиатрический медицинский университетДетский научно-клинический центр инфекционных болезнейДетский научно-клинический центр инфекционных болезнейДетский научно-клинический центр инфекционных болезнейThere is a close relationship between intestine and liver, so-called ‘gut liver’ axis, especially in patients suffered from chronic liver diseases with significant degree of fibrosis. Small intestinal bacterial overgrowth and disturbance in the microbiota composition lead to an increase in the permeability of the intestinal epithelium, the development of endotoxinemia, the activation of pro-inflammatory cytokines and, as a consequence, an additional damage to hepatocytes.Objective. To estimate the incidence of bacterial overgrowth syndrome (BOS) in the small intestine in adolescents with chronic hepatitis C (CHC), to identify the interaction between this syndrome and cytolytic activity, the degree of fibrosis.Materials and methods. There is a group of 33 patients aged 12—17 years old with CHC. All children underwent a hydrogen breath test with lactulose. The degree of fibrosis was assessed by the results of liver elastography (Fibroscan), cytolytic activity was determined by the level of alanine transaminase in serum.Results. The frequency of BOS was 81.8% in the study group. As a result of the correlation analysis, no relationship was found between the development of BOS and the degree of cytolytic activity of chronic hepatitis C (criterion χ2= 0.914, p > 0.05). Also, there was no correlation between excessive bacterial contamination and the degree of fibrosis in the liver tissue (criterion χ2= 0.914,p> 0.05).Conclusion. BOS in children with CHC occurs much more often than in adults. However, no relationship was found between this syndrome and the severity of cytolytic activity, the degree of fibrotic changes in the liver.https://detinf.elpub.ru/jour/article/view/566хронический гепатит ссиндром избыточного бактериального роста в тонком кишечникемикробиотаводородный дыхательный тестфиброз печени |
| spellingShingle | N. D. Venclovaite L. G. Goryacheva V. A. Greshnyakova N. A. Efremova I. V. Shilova Bacterial overgrowth syndrome in adolescents with Сhronic viral hepatitis C Детские инфекции (Москва) хронический гепатит с синдром избыточного бактериального роста в тонком кишечнике микробиота водородный дыхательный тест фиброз печени |
| title | Bacterial overgrowth syndrome in adolescents with Сhronic viral hepatitis C |
| title_full | Bacterial overgrowth syndrome in adolescents with Сhronic viral hepatitis C |
| title_fullStr | Bacterial overgrowth syndrome in adolescents with Сhronic viral hepatitis C |
| title_full_unstemmed | Bacterial overgrowth syndrome in adolescents with Сhronic viral hepatitis C |
| title_short | Bacterial overgrowth syndrome in adolescents with Сhronic viral hepatitis C |
| title_sort | bacterial overgrowth syndrome in adolescents with сhronic viral hepatitis c |
| topic | хронический гепатит с синдром избыточного бактериального роста в тонком кишечнике микробиота водородный дыхательный тест фиброз печени |
| url | https://detinf.elpub.ru/jour/article/view/566 |
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