The Structure and Activity of Double-Nitroimidazoles. A Mini-Review
Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells. The introduction of a second nitroimidazole ring to the molecule can improve the level of its pharmacological effect. The aim of this...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-07-01
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| Series: | Scientia Pharmaceutica |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2218-0532/86/3/30 |
| _version_ | 1828117135374680064 |
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| author | Justyna Żwawiak Lucjusz Zaprutko |
| author_facet | Justyna Żwawiak Lucjusz Zaprutko |
| author_sort | Justyna Żwawiak |
| collection | DOAJ |
| description | Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells. The introduction of a second nitroimidazole ring to the molecule can improve the level of its pharmacological effect. The aim of this article is to overview the literature concerning active compounds that contain two nitroimidazole moieties in their structures. |
| first_indexed | 2024-04-11T13:09:20Z |
| format | Article |
| id | doaj.art-857b64e8d8b4447ca37c8d3385a9a59c |
| institution | Directory Open Access Journal |
| issn | 2218-0532 |
| language | English |
| last_indexed | 2024-04-11T13:09:20Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-857b64e8d8b4447ca37c8d3385a9a59c2022-12-22T04:22:37ZengMDPI AGScientia Pharmaceutica2218-05322018-07-018633010.3390/scipharm86030030scipharm86030030The Structure and Activity of Double-Nitroimidazoles. A Mini-ReviewJustyna Żwawiak0Lucjusz Zaprutko1Pharmaceutical Faculty, Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, PolandPharmaceutical Faculty, Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, PolandMany interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells. The introduction of a second nitroimidazole ring to the molecule can improve the level of its pharmacological effect. The aim of this article is to overview the literature concerning active compounds that contain two nitroimidazole moieties in their structures.http://www.mdpi.com/2218-0532/86/3/30nitroimidazolesdouble-nitroimidazolesbis-nitroimidazolestumor hypoxiaradiosensitizers |
| spellingShingle | Justyna Żwawiak Lucjusz Zaprutko The Structure and Activity of Double-Nitroimidazoles. A Mini-Review Scientia Pharmaceutica nitroimidazoles double-nitroimidazoles bis-nitroimidazoles tumor hypoxia radiosensitizers |
| title | The Structure and Activity of Double-Nitroimidazoles. A Mini-Review |
| title_full | The Structure and Activity of Double-Nitroimidazoles. A Mini-Review |
| title_fullStr | The Structure and Activity of Double-Nitroimidazoles. A Mini-Review |
| title_full_unstemmed | The Structure and Activity of Double-Nitroimidazoles. A Mini-Review |
| title_short | The Structure and Activity of Double-Nitroimidazoles. A Mini-Review |
| title_sort | structure and activity of double nitroimidazoles a mini review |
| topic | nitroimidazoles double-nitroimidazoles bis-nitroimidazoles tumor hypoxia radiosensitizers |
| url | http://www.mdpi.com/2218-0532/86/3/30 |
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