Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature

Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature

Mitochondrial dysfunction and systemic inflammation are major factors in the development of sarcopenia, but the molecular determinants linking the two mechanisms are only partially understood. The study of extracellular vesicle (EV) trafficking may provide insights into this relationship. Circulatin...

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Bibliographic Details
Main Authors: Anna Picca, Raffaella Beli, Riccardo Calvani, Hélio José Coelho-Júnior, Francesco Landi, Roberto Bernabei, Cecilia Bucci, Flora Guerra, Emanuele Marzetti
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
aging
biomarkers
mitophagy
mitochondrial dynamics
mitochondrial quality control
mitochondrial-derived vesicles (MDVs)
Online Access:https://www.mdpi.com/2073-4409/9/4/973

Internet

https://www.mdpi.com/2073-4409/9/4/973

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