Clinical predictors of prognosis in stroke patients after endovascular therapy
Abstract Endovascular therapy (EVT) is effective in the treatment of large vascular occlusive stroke. However, many factors are associated with the outcomes of acute ischemic stroke (AIS) after EVT. This study aimed to identify the main factors related to the prognosis of AIS patients after EVT. We...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51356-5 |
| _version_ | 1797209354654449664 |
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| author | Yugang Wang Xingyun Yuan Yonggang Kang Liping Yu Wanhong Chen Gang Fan |
| author_facet | Yugang Wang Xingyun Yuan Yonggang Kang Liping Yu Wanhong Chen Gang Fan |
| author_sort | Yugang Wang |
| collection | DOAJ |
| description | Abstract Endovascular therapy (EVT) is effective in the treatment of large vascular occlusive stroke. However, many factors are associated with the outcomes of acute ischemic stroke (AIS) after EVT. This study aimed to identify the main factors related to the prognosis of AIS patients after EVT. We analyzed the clinical data of AIS patients in the neurology department of our medical center from June 2017 to August 2021 following treatment with EVT. The data included the patients’ blood pressure upon admission, blood glucose concentration, National Institutes of Health Stroke Scale (NIHSS) score, 90-day modified Rankin scale (mRs) score follow-up data, and time from LKN to the successful groin puncture (GP). A good outcome was defined as a 90-day mRs score of 0–2, and a poor outcome was defined as a 90-day mRs score of 3–6. A total of 144 patients were included in the study. Admission, smoking, and LKN-to-GP time, NIHSS score of 6–12 was found to be relevant to the prognosis. The results of multivariate analysis showed that prognosis was significantly influenced by baseline NIHSS (odds ratio = 3.02; 95% confidence interval, 2.878–4.252; P = 0.001), LKN-to-GP time (odds ratio = 2.17; 95% confidence interval, 1.341–2.625; P = 0.003), and time stratification (6–12 h) (odds ratio = 4.22; 95% confidence interval, 2.519–5.561; P = 0.001). Our study indicated that smoking, baseline NIHSS score, and LKN-to-GP time were the risk factors for a poor outcome in stroke patients following an EVT. Quitting smoking and shortening LKN time to GP should improve the outcome of AIS after EVT. |
| first_indexed | 2024-03-08T16:19:30Z |
| format | Article |
| id | doaj.art-857bea78f41948b481c8f577e7d1f7d3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T09:53:22Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-857bea78f41948b481c8f577e7d1f7d32024-04-14T11:16:06ZengNature PortfolioScientific Reports2045-23222024-01-011411710.1038/s41598-024-51356-5Clinical predictors of prognosis in stroke patients after endovascular therapyYugang Wang0Xingyun Yuan1Yonggang Kang2Liping Yu3Wanhong Chen4Gang Fan5Department of Neurology, The First People’s Hospital of Xian Yang CityDepartment of Neurology, The First People’s Hospital of Xian Yang CityDepartment of Neurology, The First People’s Hospital of Xian Yang CityDepartment of Neurology, The First People’s Hospital of Xian Yang CityDepartment of Neurology, The First People’s Hospital of Xian Yang CityDepartment of Neurology, The First People’s Hospital of Xian Yang CityAbstract Endovascular therapy (EVT) is effective in the treatment of large vascular occlusive stroke. However, many factors are associated with the outcomes of acute ischemic stroke (AIS) after EVT. This study aimed to identify the main factors related to the prognosis of AIS patients after EVT. We analyzed the clinical data of AIS patients in the neurology department of our medical center from June 2017 to August 2021 following treatment with EVT. The data included the patients’ blood pressure upon admission, blood glucose concentration, National Institutes of Health Stroke Scale (NIHSS) score, 90-day modified Rankin scale (mRs) score follow-up data, and time from LKN to the successful groin puncture (GP). A good outcome was defined as a 90-day mRs score of 0–2, and a poor outcome was defined as a 90-day mRs score of 3–6. A total of 144 patients were included in the study. Admission, smoking, and LKN-to-GP time, NIHSS score of 6–12 was found to be relevant to the prognosis. The results of multivariate analysis showed that prognosis was significantly influenced by baseline NIHSS (odds ratio = 3.02; 95% confidence interval, 2.878–4.252; P = 0.001), LKN-to-GP time (odds ratio = 2.17; 95% confidence interval, 1.341–2.625; P = 0.003), and time stratification (6–12 h) (odds ratio = 4.22; 95% confidence interval, 2.519–5.561; P = 0.001). Our study indicated that smoking, baseline NIHSS score, and LKN-to-GP time were the risk factors for a poor outcome in stroke patients following an EVT. Quitting smoking and shortening LKN time to GP should improve the outcome of AIS after EVT.https://doi.org/10.1038/s41598-024-51356-5 |
| spellingShingle | Yugang Wang Xingyun Yuan Yonggang Kang Liping Yu Wanhong Chen Gang Fan Clinical predictors of prognosis in stroke patients after endovascular therapy Scientific Reports |
| title | Clinical predictors of prognosis in stroke patients after endovascular therapy |
| title_full | Clinical predictors of prognosis in stroke patients after endovascular therapy |
| title_fullStr | Clinical predictors of prognosis in stroke patients after endovascular therapy |
| title_full_unstemmed | Clinical predictors of prognosis in stroke patients after endovascular therapy |
| title_short | Clinical predictors of prognosis in stroke patients after endovascular therapy |
| title_sort | clinical predictors of prognosis in stroke patients after endovascular therapy |
| url | https://doi.org/10.1038/s41598-024-51356-5 |
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