Serum calcitonin negative Medullary thyroid carcinoma

<p>Abstract</p> <p>Background</p> <p>Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C cells which produce Calcitonin, a hormone which has an impact on calcium metabolism and represents the biochemica...

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Main Authors: Welsing Ellen, Bonhag Gerd, Bechara Falk G, Sand Daniel, Gelos Marcos, Sand Michael, Mann Benno
Format: Article
Language:English
Published: BMC 2006-12-01
Series:World Journal of Surgical Oncology
Online Access:http://www.wjso.com/content/4/1/97
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author Welsing Ellen
Bonhag Gerd
Bechara Falk G
Sand Daniel
Gelos Marcos
Sand Michael
Mann Benno
author_facet Welsing Ellen
Bonhag Gerd
Bechara Falk G
Sand Daniel
Gelos Marcos
Sand Michael
Mann Benno
author_sort Welsing Ellen
collection DOAJ
description <p>Abstract</p> <p>Background</p> <p>Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C cells which produce Calcitonin, a hormone which has an impact on calcium metabolism and represents the biochemical activity of MTC. In rare cases pre-operative serum calcitonin can be negative.</p> <p>Case presentation</p> <p>We report on a 73-year-old female patient with a rare case of a serum calcitonin negative medullary thyroid carcinoma who suffered fulminant post-operative course and died of multiple metastasis.</p> <p>Conclusion</p> <p>This case shows that in very rare cases MTCs do not secrete calcitonin making diagnosis and tumour follow-up difficult. To this date, only few reports describing this combination of circumstances were found in the English literature.</p>
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spelling doaj.art-857c26f0f8424bc19431a4d58abc5d0c2022-12-22T01:51:50ZengBMCWorld Journal of Surgical Oncology1477-78192006-12-01419710.1186/1477-7819-4-97Serum calcitonin negative Medullary thyroid carcinomaWelsing EllenBonhag GerdBechara Falk GSand DanielGelos MarcosSand MichaelMann Benno<p>Abstract</p> <p>Background</p> <p>Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C cells which produce Calcitonin, a hormone which has an impact on calcium metabolism and represents the biochemical activity of MTC. In rare cases pre-operative serum calcitonin can be negative.</p> <p>Case presentation</p> <p>We report on a 73-year-old female patient with a rare case of a serum calcitonin negative medullary thyroid carcinoma who suffered fulminant post-operative course and died of multiple metastasis.</p> <p>Conclusion</p> <p>This case shows that in very rare cases MTCs do not secrete calcitonin making diagnosis and tumour follow-up difficult. To this date, only few reports describing this combination of circumstances were found in the English literature.</p>http://www.wjso.com/content/4/1/97
spellingShingle Welsing Ellen
Bonhag Gerd
Bechara Falk G
Sand Daniel
Gelos Marcos
Sand Michael
Mann Benno
Serum calcitonin negative Medullary thyroid carcinoma
World Journal of Surgical Oncology
title Serum calcitonin negative Medullary thyroid carcinoma
title_full Serum calcitonin negative Medullary thyroid carcinoma
title_fullStr Serum calcitonin negative Medullary thyroid carcinoma
title_full_unstemmed Serum calcitonin negative Medullary thyroid carcinoma
title_short Serum calcitonin negative Medullary thyroid carcinoma
title_sort serum calcitonin negative medullary thyroid carcinoma
url http://www.wjso.com/content/4/1/97
work_keys_str_mv AT welsingellen serumcalcitoninnegativemedullarythyroidcarcinoma
AT bonhaggerd serumcalcitoninnegativemedullarythyroidcarcinoma
AT becharafalkg serumcalcitoninnegativemedullarythyroidcarcinoma
AT sanddaniel serumcalcitoninnegativemedullarythyroidcarcinoma
AT gelosmarcos serumcalcitoninnegativemedullarythyroidcarcinoma
AT sandmichael serumcalcitoninnegativemedullarythyroidcarcinoma
AT mannbenno serumcalcitoninnegativemedullarythyroidcarcinoma