Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors
Widespread microRNA (miRNA) repression is a phenomenon observed in mammals after exposure to cigarette smoke and in many types of cancer. A comprehensive reduction in miRNA expression after treatment with the hormone estrogen has also previously been described. Here, we reveal a conserved associatio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/5/3/47 |
| _version_ | 1811270064964370432 |
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| author | Amit Cohen Mario Alberto Burgos-Aceves Tamar Kahan Yoav Smith |
| author_facet | Amit Cohen Mario Alberto Burgos-Aceves Tamar Kahan Yoav Smith |
| author_sort | Amit Cohen |
| collection | DOAJ |
| description | Widespread microRNA (miRNA) repression is a phenomenon observed in mammals after exposure to cigarette smoke and in many types of cancer. A comprehensive reduction in miRNA expression after treatment with the hormone estrogen has also previously been described. Here, we reveal a conserved association of miRNA downregulation after estrogen exposure in zebrafish, mouse, and human breast cancer cell line, with a high guanine content in the terminal loop sequences of their precursors, and offer a possible link between estrogen-related miRNA-adducts formation and carcinogenesis. We also show common gene expression patterns shared by breast cancer tumors and estrogen-treated zebrafish, suggesting that this organism can be used as a powerful model system for the study of human breast cancer. |
| first_indexed | 2024-04-12T21:54:16Z |
| format | Article |
| id | doaj.art-857c345a10de440996cefc8fae6d19dd |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-04-12T21:54:16Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-857c345a10de440996cefc8fae6d19dd2022-12-22T03:15:22ZengMDPI AGBiomedicines2227-90592017-08-01534710.3390/biomedicines5030047biomedicines5030047Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their PrecursorsAmit Cohen0Mario Alberto Burgos-Aceves1Tamar Kahan2Yoav Smith3Genomic Data Analysis Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, IsraelLaboratorio de Endocrinología, Centro de Investigaciones Biológicas del Noroeste, Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz 23096, B.C.S., MexicoBioinformatics Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, IsraelGenomic Data Analysis Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, IsraelWidespread microRNA (miRNA) repression is a phenomenon observed in mammals after exposure to cigarette smoke and in many types of cancer. A comprehensive reduction in miRNA expression after treatment with the hormone estrogen has also previously been described. Here, we reveal a conserved association of miRNA downregulation after estrogen exposure in zebrafish, mouse, and human breast cancer cell line, with a high guanine content in the terminal loop sequences of their precursors, and offer a possible link between estrogen-related miRNA-adducts formation and carcinogenesis. We also show common gene expression patterns shared by breast cancer tumors and estrogen-treated zebrafish, suggesting that this organism can be used as a powerful model system for the study of human breast cancer.https://www.mdpi.com/2227-9059/5/3/47estrogenmicroRNATerminal loopGuaninecigarette smokexenoestrogensDNA adductscancer |
| spellingShingle | Amit Cohen Mario Alberto Burgos-Aceves Tamar Kahan Yoav Smith Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors Biomedicines estrogen microRNA Terminal loop Guanine cigarette smoke xenoestrogens DNA adducts cancer |
| title | Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors |
| title_full | Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors |
| title_fullStr | Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors |
| title_full_unstemmed | Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors |
| title_short | Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors |
| title_sort | estrogen repression of micrornas is associated with high guanine content in the terminal loop sequences of their precursors |
| topic | estrogen microRNA Terminal loop Guanine cigarette smoke xenoestrogens DNA adducts cancer |
| url | https://www.mdpi.com/2227-9059/5/3/47 |
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