Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold
Abstract Opioid inhibition of nociceptive stimuli varies in individuals and is difficult to titrate. We have reported the vascular stiffness value (K) as a standard monitor to quantify sympathetic response with high accuracy. On the contrary, among individuals, a considerable variation in the rate o...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-87636-7 |
| _version_ | 1818754088434663424 |
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| author | Satoshi Kamiya Ryuji Nakamura Noboru Saeki Takashi Kondo Hirotsugu Miyoshi Soushi Narasaki Atsushi Morio Masashi Kawamoto Harutoyo Hirano Toshio Tsuji Yasuo M. Tsutsumi |
| author_facet | Satoshi Kamiya Ryuji Nakamura Noboru Saeki Takashi Kondo Hirotsugu Miyoshi Soushi Narasaki Atsushi Morio Masashi Kawamoto Harutoyo Hirano Toshio Tsuji Yasuo M. Tsutsumi |
| author_sort | Satoshi Kamiya |
| collection | DOAJ |
| description | Abstract Opioid inhibition of nociceptive stimuli varies in individuals and is difficult to titrate. We have reported the vascular stiffness value (K) as a standard monitor to quantify sympathetic response with high accuracy. On the contrary, among individuals, a considerable variation in the rate of change in K for constant pain has been observed. In this study, we proposed a new index, the minimum stimulus intensity value that evoked the response on K (MECK: Minimum Evoked Current of K), and evaluated its accuracy in predicting sympathetic response to nociceptive stimuli under constant opioid administration. Thirty patients undergoing open surgery under general anesthesia were included. After anesthetic induction, remifentanil was administered at a constant concentration of 2 ng/ml at the effect site followed by tetanus stimulation. MECK was defined as the minimal current needed to produce a change in K. MECK significantly (P < 0.001) correlated with the rate of change of systolic blood pressure during skin incision (ROCBP). Bland–Altman plot analysis using the predicted ROCBP calculated from MECK and the measured ROCBP showed that the prediction equation for ROCBP was highly accurate. This study showed the potential of MECK to predict blood pressure change during surgical incision under opioid analgesia. Clinical trial registration Registry: University hospital medical information network; Registration number: UMIN000041816; Principal investigator's name: Satoshi Kamiya; Date of registration: July 9th, 2019. |
| first_indexed | 2024-12-18T05:17:41Z |
| format | Article |
| id | doaj.art-857cb9a71e31471daa83704d88a392c4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T05:17:41Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-857cb9a71e31471daa83704d88a392c42022-12-21T21:19:44ZengNature PortfolioScientific Reports2045-23222021-05-0111111010.1038/s41598-021-87636-7Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking thresholdSatoshi Kamiya0Ryuji Nakamura1Noboru Saeki2Takashi Kondo3Hirotsugu Miyoshi4Soushi Narasaki5Atsushi Morio6Masashi Kawamoto7Harutoyo Hirano8Toshio Tsuji9Yasuo M. Tsutsumi10Department of Anesthesiology and Critical Care, Hiroshima UniversityDepartment of Anesthesiology and Critical Care, Hiroshima UniversityDepartment of Anesthesiology and Critical Care, Hiroshima UniversityDepartment of Anesthesiology and Critical Care, Hiroshima UniversityDepartment of Anesthesiology and Critical Care, Hiroshima UniversityDepartment of Anesthesiology and Critical Care, Hiroshima UniversityDepartment of Anesthesiology and Critical Care, Hiroshima UniversityMedical Corporation JR Hiroshima HospitalAcademic Institute, College of Engineering, Shizuoka UniversityGraduate School of Advanced Science and Engineering, Hiroshima UniversityDepartment of Anesthesiology and Critical Care, Hiroshima UniversityAbstract Opioid inhibition of nociceptive stimuli varies in individuals and is difficult to titrate. We have reported the vascular stiffness value (K) as a standard monitor to quantify sympathetic response with high accuracy. On the contrary, among individuals, a considerable variation in the rate of change in K for constant pain has been observed. In this study, we proposed a new index, the minimum stimulus intensity value that evoked the response on K (MECK: Minimum Evoked Current of K), and evaluated its accuracy in predicting sympathetic response to nociceptive stimuli under constant opioid administration. Thirty patients undergoing open surgery under general anesthesia were included. After anesthetic induction, remifentanil was administered at a constant concentration of 2 ng/ml at the effect site followed by tetanus stimulation. MECK was defined as the minimal current needed to produce a change in K. MECK significantly (P < 0.001) correlated with the rate of change of systolic blood pressure during skin incision (ROCBP). Bland–Altman plot analysis using the predicted ROCBP calculated from MECK and the measured ROCBP showed that the prediction equation for ROCBP was highly accurate. This study showed the potential of MECK to predict blood pressure change during surgical incision under opioid analgesia. Clinical trial registration Registry: University hospital medical information network; Registration number: UMIN000041816; Principal investigator's name: Satoshi Kamiya; Date of registration: July 9th, 2019.https://doi.org/10.1038/s41598-021-87636-7 |
| spellingShingle | Satoshi Kamiya Ryuji Nakamura Noboru Saeki Takashi Kondo Hirotsugu Miyoshi Soushi Narasaki Atsushi Morio Masashi Kawamoto Harutoyo Hirano Toshio Tsuji Yasuo M. Tsutsumi Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold Scientific Reports |
| title | Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold |
| title_full | Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold |
| title_fullStr | Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold |
| title_full_unstemmed | Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold |
| title_short | Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold |
| title_sort | prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold |
| url | https://doi.org/10.1038/s41598-021-87636-7 |
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