Outcomes of descemet stripping automated endothelial keratoplasty using imported donor corneas
Abstract Background The lack of development of local donor tissue acquisition in several regions of the world has resulted in the necessity of performing keratoplasty with imported donor corneas. The greatest concern about the use of donor corneas supplied by foreign eye banks is the effect of the i...
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| Format: | Article |
| Language: | English |
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BMC
2017-04-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://link.springer.com/article/10.1186/s12886-017-0436-0 |
| _version_ | 1811278119653343232 |
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| author | Kaevalin Lekhanont Kavin Vanikieti Nutthida Nimvorapun Varintorn Chuckpaiwong |
| author_facet | Kaevalin Lekhanont Kavin Vanikieti Nutthida Nimvorapun Varintorn Chuckpaiwong |
| author_sort | Kaevalin Lekhanont |
| collection | DOAJ |
| description | Abstract Background The lack of development of local donor tissue acquisition in several regions of the world has resulted in the necessity of performing keratoplasty with imported donor corneas. The greatest concern about the use of donor corneas supplied by foreign eye banks is the effect of the increased donor death-to-operation time which inevitably occurs during the tissue recovery, tissue processing, and tissue transfer between the countries. The purpose of this study was to report the outcomes of descemet stripping automated endothelial keratoplasty (DSAEK) using imported donor corneas. Methods This retrospective, non-comparative case series investigated the outcomes of the 102 consecutive DSAEK procedures using imported donor corneas performed at a single university-based hospital between August 2006–2014. The main outcome measures were postoperative best-corrected visual acuity (BCVA), endothelial cell density (ECD), and complications. Results The mean death-to-operation time was 9.52 ± 1.48 days (range, 8–13). The mean preoperative ECD was 2761 ± 285 cells/mm2. Fuchs’ endothelial dystrophy was the predominant indication for grafting. The mean follow-up duration was 65.3 months. Ninety-three eyes had improved vision postoperatively (91.18%). BCVA unchanged in 3 eyes due to preexisting macular scar and advanced glaucoma. Primary graft failure occurred in 6 eyes (5.88%). Of the 93 eyes with improved BCVA, 100% had their best corrected vision within the first 1 year. The mean ECD at 6, 12, 24, 36, and 60 months after surgery was 1762 ± 294 cells/mm2, 1681 ± 284 cells/mm2, 1579 ± 209 cells/mm2, 1389 ± 273 cells/mm2, and 1251 ± 264 cells/mm2 respectively. The mean ECD loss at 6 months, 1 year, 2 years, 3 years, and 5 years after surgery was 36.2%, 39.1%, 42.8%, 49.7%, and 54.7% respectively. The most common complication was graft detachment/dislocation (10.78%). There were no cases of any postoperative infection. Conclusions DSAEK with imported donor corneas provides rapid and good visual rehabilitation. The percentages of endothelial cell loss were comparable to those achieved in Western series using domestic corneas in which fresher tissues were available for transplantation. |
| first_indexed | 2024-04-13T00:30:08Z |
| format | Article |
| id | doaj.art-8581c95c609a43b3a44cfedc9e82c0bc |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-13T00:30:08Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj.art-8581c95c609a43b3a44cfedc9e82c0bc2022-12-22T03:10:30ZengBMCBMC Ophthalmology1471-24152017-04-011711810.1186/s12886-017-0436-0Outcomes of descemet stripping automated endothelial keratoplasty using imported donor corneasKaevalin Lekhanont0Kavin Vanikieti1Nutthida Nimvorapun2Varintorn Chuckpaiwong3Department of Ophthalmology, Ramathibodi Hospital, Mahidol UniversityDepartment of Ophthalmology, Ramathibodi Hospital, Mahidol UniversityDepartment of Ophthalmology, Ramathibodi Hospital, Mahidol UniversityDepartment of Ophthalmology, Ramathibodi Hospital, Mahidol UniversityAbstract Background The lack of development of local donor tissue acquisition in several regions of the world has resulted in the necessity of performing keratoplasty with imported donor corneas. The greatest concern about the use of donor corneas supplied by foreign eye banks is the effect of the increased donor death-to-operation time which inevitably occurs during the tissue recovery, tissue processing, and tissue transfer between the countries. The purpose of this study was to report the outcomes of descemet stripping automated endothelial keratoplasty (DSAEK) using imported donor corneas. Methods This retrospective, non-comparative case series investigated the outcomes of the 102 consecutive DSAEK procedures using imported donor corneas performed at a single university-based hospital between August 2006–2014. The main outcome measures were postoperative best-corrected visual acuity (BCVA), endothelial cell density (ECD), and complications. Results The mean death-to-operation time was 9.52 ± 1.48 days (range, 8–13). The mean preoperative ECD was 2761 ± 285 cells/mm2. Fuchs’ endothelial dystrophy was the predominant indication for grafting. The mean follow-up duration was 65.3 months. Ninety-three eyes had improved vision postoperatively (91.18%). BCVA unchanged in 3 eyes due to preexisting macular scar and advanced glaucoma. Primary graft failure occurred in 6 eyes (5.88%). Of the 93 eyes with improved BCVA, 100% had their best corrected vision within the first 1 year. The mean ECD at 6, 12, 24, 36, and 60 months after surgery was 1762 ± 294 cells/mm2, 1681 ± 284 cells/mm2, 1579 ± 209 cells/mm2, 1389 ± 273 cells/mm2, and 1251 ± 264 cells/mm2 respectively. The mean ECD loss at 6 months, 1 year, 2 years, 3 years, and 5 years after surgery was 36.2%, 39.1%, 42.8%, 49.7%, and 54.7% respectively. The most common complication was graft detachment/dislocation (10.78%). There were no cases of any postoperative infection. Conclusions DSAEK with imported donor corneas provides rapid and good visual rehabilitation. The percentages of endothelial cell loss were comparable to those achieved in Western series using domestic corneas in which fresher tissues were available for transplantation.http://link.springer.com/article/10.1186/s12886-017-0436-0Descemet stripping automated endothelial keratoplastyOutcomesImported donor corneas |
| spellingShingle | Kaevalin Lekhanont Kavin Vanikieti Nutthida Nimvorapun Varintorn Chuckpaiwong Outcomes of descemet stripping automated endothelial keratoplasty using imported donor corneas BMC Ophthalmology Descemet stripping automated endothelial keratoplasty Outcomes Imported donor corneas |
| title | Outcomes of descemet stripping automated endothelial keratoplasty using imported donor corneas |
| title_full | Outcomes of descemet stripping automated endothelial keratoplasty using imported donor corneas |
| title_fullStr | Outcomes of descemet stripping automated endothelial keratoplasty using imported donor corneas |
| title_full_unstemmed | Outcomes of descemet stripping automated endothelial keratoplasty using imported donor corneas |
| title_short | Outcomes of descemet stripping automated endothelial keratoplasty using imported donor corneas |
| title_sort | outcomes of descemet stripping automated endothelial keratoplasty using imported donor corneas |
| topic | Descemet stripping automated endothelial keratoplasty Outcomes Imported donor corneas |
| url | http://link.springer.com/article/10.1186/s12886-017-0436-0 |
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