Liver stiffness value obtained by point shear-wave elastography is significantly related with atrial septal defect size
PURPOSEThe increase in volume and pressure in the right atrium (RA) and right ventricle (RV) has been shown to increase the liver stiffness (LS). In the literature, there is no information about the changes in LS value in patients with atrial septal defect (ASD). The aim of our study was to investig...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2020-07-01
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| Series: | Diagnostic and Interventional Radiology |
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http://www.dirjournal.org/archives/archive-detail/article-preview/liver-stiffness-value-obtained-by-point-shear-wave/54716
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| _version_ | 1797691287753719808 |
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| author | Mehmet Küçükosmanoğlu Ayşe Selcan Koç Hilmi Erdem Sümbül Hasan Koca Burçak Çakır Pekoz Mevlüt Koç |
| author_facet | Mehmet Küçükosmanoğlu Ayşe Selcan Koç Hilmi Erdem Sümbül Hasan Koca Burçak Çakır Pekoz Mevlüt Koç |
| author_sort | Mehmet Küçükosmanoğlu |
| collection | DOAJ |
| description | PURPOSEThe increase in volume and pressure in the right atrium (RA) and right ventricle (RV) has been shown to increase the liver stiffness (LS). In the literature, there is no information about the changes in LS value in patients with atrial septal defect (ASD). The aim of our study was to investigate the change of LS values obtained by point shear-wave elastography (pSWE) in patients with ASD and the clinical utility of pSWE for this disease.METHODSThis cross-sectional study included 66 patients with ostium secundum ASD: 21 patients with no indication for ASD closure (Group I), 38 patients who underwent ASD closure (Group II), and 7 patients who had ASD with Eisenmenger syndrome (Group III). All patients underwent echocardiography and pSWE. Increased LS was accepted as ≥7 kPa.RESULTSLS values as well as transaminases, clinical signs of heart failure and functional and structural heart abnormalities (increase of RA and RV diastolic dimensions, tricuspid regurgitation pressure gradient [TRPG], ASD size and decrease of ejection fraction, tricuspid annular plane systolic excursion) significantly increased from Group I to Group III (P < 0.001 for all comparisons). Mean LS values for Group I, Group II, and Group III were 5.16±1.55 kPa, 7.48±1.99 kPa, and 13.9±2.58 kPa, respectively. In multivariate linear regression analysis, ASD size and TRPG were significantly associated with LS increase. Only ASD size independently predicted abnormal LS increase ≥7 kPa according to multivariate logistic regression. Clinical value of LS increase was comparable to TRPG for detection of Eisenmenger syndrome; in the receiver operating curve analysis, area under the curve was 0.995 for LS (P < 0.001) and 0.990 for TRPG (P < 0.001). At 10 kPa threshold, LS determined the Eisenmenger syndrome with 100% sensitivity and 91.5% specificity.CONCLUSIONLS value assessed by pSWE was significantly increased in ASD patients with closure indication and Eisenmenger syndrome compared to patients without ASD closure indication and was comparable with TRPG in regards to Eisenmenger syndrome identification. ASD size significantly associated with LS and independently predicted abnormal LS increase ≥7 kPa. |
| first_indexed | 2024-03-12T02:11:17Z |
| format | Article |
| id | doaj.art-85869ea71173424cb42665653128a4d8 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:11:17Z |
| publishDate | 2020-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-85869ea71173424cb42665653128a4d82023-09-06T13:00:27ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122020-07-0126428429110.5152/dir.2019.1928713049054Liver stiffness value obtained by point shear-wave elastography is significantly related with atrial septal defect sizeMehmet Küçükosmanoğlu0Ayşe Selcan Koç1Hilmi Erdem Sümbül2Hasan Koca3Burçak Çakır Pekoz4Mevlüt Koç5 Department of Cardiology, University of Health Sciences Adana Health Practice and Research Center, Adana, Turkey Department of Radiology, University of Health Sciences Adana Health Practice and Research Center, Adana, Turkey Department of Internal Medicine, University of Health Sciences Adana Health Practice and Research Center, Adana, Turkey Department of Cardiology, University of Health Sciences Adana Health Practice and Research Center, Adana, Turkey Department of Radiology, University of Health Sciences Adana Health Practice and Research Center, Adana, Turkey Department of Cardiology, University of Health Sciences Adana Health Practice and Research Center, Adana, Turkey PURPOSEThe increase in volume and pressure in the right atrium (RA) and right ventricle (RV) has been shown to increase the liver stiffness (LS). In the literature, there is no information about the changes in LS value in patients with atrial septal defect (ASD). The aim of our study was to investigate the change of LS values obtained by point shear-wave elastography (pSWE) in patients with ASD and the clinical utility of pSWE for this disease.METHODSThis cross-sectional study included 66 patients with ostium secundum ASD: 21 patients with no indication for ASD closure (Group I), 38 patients who underwent ASD closure (Group II), and 7 patients who had ASD with Eisenmenger syndrome (Group III). All patients underwent echocardiography and pSWE. Increased LS was accepted as ≥7 kPa.RESULTSLS values as well as transaminases, clinical signs of heart failure and functional and structural heart abnormalities (increase of RA and RV diastolic dimensions, tricuspid regurgitation pressure gradient [TRPG], ASD size and decrease of ejection fraction, tricuspid annular plane systolic excursion) significantly increased from Group I to Group III (P < 0.001 for all comparisons). Mean LS values for Group I, Group II, and Group III were 5.16±1.55 kPa, 7.48±1.99 kPa, and 13.9±2.58 kPa, respectively. In multivariate linear regression analysis, ASD size and TRPG were significantly associated with LS increase. Only ASD size independently predicted abnormal LS increase ≥7 kPa according to multivariate logistic regression. Clinical value of LS increase was comparable to TRPG for detection of Eisenmenger syndrome; in the receiver operating curve analysis, area under the curve was 0.995 for LS (P < 0.001) and 0.990 for TRPG (P < 0.001). At 10 kPa threshold, LS determined the Eisenmenger syndrome with 100% sensitivity and 91.5% specificity.CONCLUSIONLS value assessed by pSWE was significantly increased in ASD patients with closure indication and Eisenmenger syndrome compared to patients without ASD closure indication and was comparable with TRPG in regards to Eisenmenger syndrome identification. ASD size significantly associated with LS and independently predicted abnormal LS increase ≥7 kPa. http://www.dirjournal.org/archives/archive-detail/article-preview/liver-stiffness-value-obtained-by-point-shear-wave/54716 |
| spellingShingle | Mehmet Küçükosmanoğlu Ayşe Selcan Koç Hilmi Erdem Sümbül Hasan Koca Burçak Çakır Pekoz Mevlüt Koç Liver stiffness value obtained by point shear-wave elastography is significantly related with atrial septal defect size Diagnostic and Interventional Radiology |
| title | Liver stiffness value obtained by point shear-wave elastography is significantly related with atrial septal defect size |
| title_full | Liver stiffness value obtained by point shear-wave elastography is significantly related with atrial septal defect size |
| title_fullStr | Liver stiffness value obtained by point shear-wave elastography is significantly related with atrial septal defect size |
| title_full_unstemmed | Liver stiffness value obtained by point shear-wave elastography is significantly related with atrial septal defect size |
| title_short | Liver stiffness value obtained by point shear-wave elastography is significantly related with atrial septal defect size |
| title_sort | liver stiffness value obtained by point shear wave elastography is significantly related with atrial septal defect size |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/liver-stiffness-value-obtained-by-point-shear-wave/54716
|
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