Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study

Abstract Background Lifestyle adjustment has been reported as one of the interventions for dyslipidemia. This study aimed to explore the effect of overall lifestyle on the risk of all-cause mortality and cardiovascular disease (CVD) death in dyslipidemia patients with or without lipid-lowering thera...

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Main Authors: Qian Wang, Dong Pang, Hui Wang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Cardiovascular Disorders
Subjects:
Online Access:https://doi.org/10.1186/s12872-023-03450-1
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author Qian Wang
Dong Pang
Hui Wang
author_facet Qian Wang
Dong Pang
Hui Wang
author_sort Qian Wang
collection DOAJ
description Abstract Background Lifestyle adjustment has been reported as one of the interventions for dyslipidemia. This study aimed to explore the effect of overall lifestyle on the risk of all-cause mortality and cardiovascular disease (CVD) death in dyslipidemia patients with or without lipid-lowering therapy. Methods This was a retrospective cohort study, and data were extracted from the National Health and Nutrition Examination Survey (NHANES). Overall lifestyle was assessed based on Mediterranean diet score, physical activity, smoking status, sleep duration, and body mass index (BMI). Multivariate Cox regression model was used to explore the effect of overall lifestyle score on the risk of all-cause mortality and CVD death. Results were shown as hazard ratio (HR), with 95% confidence interval (CI). Results A total of 11,549 dyslipidemia patients were finally included in this study. The results showed that optimal overall lifestyle was associated with the decreased risk of all-cause mortality (HR = 0.47, 95%CI: 0.34–0.64) and CVD death (HR = 0.45, 95%CI: 0.22–0.94) in patients without lipid-lowering therapy. The similar results were found in patients with lipid-lowering therapy (all-cause mortality: HR = 0.45, 95%CI: 0.33–0.62; CVD death: HR = 0.38, 95%CI: 0.23–0.63). Conclusions A favorable overall lifestyle may have great benefits to improve the prognosis of dyslipidemia, highlighting the importance of overall lifestyle adjustment for dyslipidemia patients.
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spelling doaj.art-8587bf556ad34a11a851314fa200fc7b2023-11-26T12:16:55ZengBMCBMC Cardiovascular Disorders1471-22612023-09-0123111010.1186/s12872-023-03450-1Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort studyQian Wang0Dong Pang1Hui Wang2Changsheng Community Health Service Station, Jinan HospitalDepartment of General Practice, Jinan HospitalDepartment of Emergency, Jinan HospitalAbstract Background Lifestyle adjustment has been reported as one of the interventions for dyslipidemia. This study aimed to explore the effect of overall lifestyle on the risk of all-cause mortality and cardiovascular disease (CVD) death in dyslipidemia patients with or without lipid-lowering therapy. Methods This was a retrospective cohort study, and data were extracted from the National Health and Nutrition Examination Survey (NHANES). Overall lifestyle was assessed based on Mediterranean diet score, physical activity, smoking status, sleep duration, and body mass index (BMI). Multivariate Cox regression model was used to explore the effect of overall lifestyle score on the risk of all-cause mortality and CVD death. Results were shown as hazard ratio (HR), with 95% confidence interval (CI). Results A total of 11,549 dyslipidemia patients were finally included in this study. The results showed that optimal overall lifestyle was associated with the decreased risk of all-cause mortality (HR = 0.47, 95%CI: 0.34–0.64) and CVD death (HR = 0.45, 95%CI: 0.22–0.94) in patients without lipid-lowering therapy. The similar results were found in patients with lipid-lowering therapy (all-cause mortality: HR = 0.45, 95%CI: 0.33–0.62; CVD death: HR = 0.38, 95%CI: 0.23–0.63). Conclusions A favorable overall lifestyle may have great benefits to improve the prognosis of dyslipidemia, highlighting the importance of overall lifestyle adjustment for dyslipidemia patients.https://doi.org/10.1186/s12872-023-03450-1Overall lifestyleDyslipidemiaAll-cause mortalityCVD death
spellingShingle Qian Wang
Dong Pang
Hui Wang
Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study
BMC Cardiovascular Disorders
Overall lifestyle
Dyslipidemia
All-cause mortality
CVD death
title Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study
title_full Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study
title_fullStr Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study
title_full_unstemmed Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study
title_short Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study
title_sort effect of overall lifestyle on the all cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid lowering therapy a cohort study
topic Overall lifestyle
Dyslipidemia
All-cause mortality
CVD death
url https://doi.org/10.1186/s12872-023-03450-1
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