Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study
Abstract Background Lifestyle adjustment has been reported as one of the interventions for dyslipidemia. This study aimed to explore the effect of overall lifestyle on the risk of all-cause mortality and cardiovascular disease (CVD) death in dyslipidemia patients with or without lipid-lowering thera...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2023-09-01
|
Series: | BMC Cardiovascular Disorders |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12872-023-03450-1 |
_version_ | 1797453953210777600 |
---|---|
author | Qian Wang Dong Pang Hui Wang |
author_facet | Qian Wang Dong Pang Hui Wang |
author_sort | Qian Wang |
collection | DOAJ |
description | Abstract Background Lifestyle adjustment has been reported as one of the interventions for dyslipidemia. This study aimed to explore the effect of overall lifestyle on the risk of all-cause mortality and cardiovascular disease (CVD) death in dyslipidemia patients with or without lipid-lowering therapy. Methods This was a retrospective cohort study, and data were extracted from the National Health and Nutrition Examination Survey (NHANES). Overall lifestyle was assessed based on Mediterranean diet score, physical activity, smoking status, sleep duration, and body mass index (BMI). Multivariate Cox regression model was used to explore the effect of overall lifestyle score on the risk of all-cause mortality and CVD death. Results were shown as hazard ratio (HR), with 95% confidence interval (CI). Results A total of 11,549 dyslipidemia patients were finally included in this study. The results showed that optimal overall lifestyle was associated with the decreased risk of all-cause mortality (HR = 0.47, 95%CI: 0.34–0.64) and CVD death (HR = 0.45, 95%CI: 0.22–0.94) in patients without lipid-lowering therapy. The similar results were found in patients with lipid-lowering therapy (all-cause mortality: HR = 0.45, 95%CI: 0.33–0.62; CVD death: HR = 0.38, 95%CI: 0.23–0.63). Conclusions A favorable overall lifestyle may have great benefits to improve the prognosis of dyslipidemia, highlighting the importance of overall lifestyle adjustment for dyslipidemia patients. |
first_indexed | 2024-03-09T15:30:19Z |
format | Article |
id | doaj.art-8587bf556ad34a11a851314fa200fc7b |
institution | Directory Open Access Journal |
issn | 1471-2261 |
language | English |
last_indexed | 2024-03-09T15:30:19Z |
publishDate | 2023-09-01 |
publisher | BMC |
record_format | Article |
series | BMC Cardiovascular Disorders |
spelling | doaj.art-8587bf556ad34a11a851314fa200fc7b2023-11-26T12:16:55ZengBMCBMC Cardiovascular Disorders1471-22612023-09-0123111010.1186/s12872-023-03450-1Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort studyQian Wang0Dong Pang1Hui Wang2Changsheng Community Health Service Station, Jinan HospitalDepartment of General Practice, Jinan HospitalDepartment of Emergency, Jinan HospitalAbstract Background Lifestyle adjustment has been reported as one of the interventions for dyslipidemia. This study aimed to explore the effect of overall lifestyle on the risk of all-cause mortality and cardiovascular disease (CVD) death in dyslipidemia patients with or without lipid-lowering therapy. Methods This was a retrospective cohort study, and data were extracted from the National Health and Nutrition Examination Survey (NHANES). Overall lifestyle was assessed based on Mediterranean diet score, physical activity, smoking status, sleep duration, and body mass index (BMI). Multivariate Cox regression model was used to explore the effect of overall lifestyle score on the risk of all-cause mortality and CVD death. Results were shown as hazard ratio (HR), with 95% confidence interval (CI). Results A total of 11,549 dyslipidemia patients were finally included in this study. The results showed that optimal overall lifestyle was associated with the decreased risk of all-cause mortality (HR = 0.47, 95%CI: 0.34–0.64) and CVD death (HR = 0.45, 95%CI: 0.22–0.94) in patients without lipid-lowering therapy. The similar results were found in patients with lipid-lowering therapy (all-cause mortality: HR = 0.45, 95%CI: 0.33–0.62; CVD death: HR = 0.38, 95%CI: 0.23–0.63). Conclusions A favorable overall lifestyle may have great benefits to improve the prognosis of dyslipidemia, highlighting the importance of overall lifestyle adjustment for dyslipidemia patients.https://doi.org/10.1186/s12872-023-03450-1Overall lifestyleDyslipidemiaAll-cause mortalityCVD death |
spellingShingle | Qian Wang Dong Pang Hui Wang Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study BMC Cardiovascular Disorders Overall lifestyle Dyslipidemia All-cause mortality CVD death |
title | Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study |
title_full | Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study |
title_fullStr | Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study |
title_full_unstemmed | Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study |
title_short | Effect of overall lifestyle on the all-cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid-lowering therapy: a cohort study |
title_sort | effect of overall lifestyle on the all cause mortality and cardiovascular disease death in dyslipidemia patients with or without lipid lowering therapy a cohort study |
topic | Overall lifestyle Dyslipidemia All-cause mortality CVD death |
url | https://doi.org/10.1186/s12872-023-03450-1 |
work_keys_str_mv | AT qianwang effectofoveralllifestyleontheallcausemortalityandcardiovasculardiseasedeathindyslipidemiapatientswithorwithoutlipidloweringtherapyacohortstudy AT dongpang effectofoveralllifestyleontheallcausemortalityandcardiovasculardiseasedeathindyslipidemiapatientswithorwithoutlipidloweringtherapyacohortstudy AT huiwang effectofoveralllifestyleontheallcausemortalityandcardiovasculardiseasedeathindyslipidemiapatientswithorwithoutlipidloweringtherapyacohortstudy |