Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study
Abstract Background Helicobacter pylori causes peptic ulcer disease and gastric cancer only in a subset of infected persons. Sex differences were shown in results of urea breath test (UBT), a commonly used test for the diagnosis of H. pylori infection. However, factors that might explain these diffe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13293-017-0161-7 |
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| author | Ido Eisdorfer Varda Shalev Sophy Goren Gabriel Chodick Khitam Muhsen |
| author_facet | Ido Eisdorfer Varda Shalev Sophy Goren Gabriel Chodick Khitam Muhsen |
| author_sort | Ido Eisdorfer |
| collection | DOAJ |
| description | Abstract Background Helicobacter pylori causes peptic ulcer disease and gastric cancer only in a subset of infected persons. Sex differences were shown in results of urea breath test (UBT), a commonly used test for the diagnosis of H. pylori infection. However, factors that might explain these differences, or affect UBT values, are not fully understood. We examined differences in UBT values between H. pylori-infected men and women while adjusting for background characteristics such as age, body mass index (BMI), and smoking. Methods A cross-sectional study was undertaken using coded data from the computerized database of Maccabi Health Services in Israel. Included were adults examined for UBT during 2002–2012 and were found H. pylori positive (UBT > 3.5‰). Multivariable linear mixed models were performed to assess the relationship between sex and UBT quantitative results, while adjusting for background characteristics. Results A total of 76,403 patients were included (52% of examined patients during the study period). Adjusted mean UBT value was significantly higher in women 33.8‰ (95% CI 33.4, 34.1) than in men 24.9‰ (95% CI 24.5, 25.3). A significant (P < 0.001) interaction was found between sex and smoking, showing diminished sex-differences in UBT results in smokers. Adjusted mean UBT values increased significantly with age and decreased with BMI, and it was higher in people who lived in low vs high socioeconomic status communities and lower in smokers vs non-smokers. Conclusions Systemic differences exist between men and women in quantitative UBT results. Host-related and environmental factors might affect UBT quantitative results. These findings have clinical implications regarding confirmation of the success of H. pylori eradication after treatment in various subgroups. |
| first_indexed | 2024-04-12T08:54:11Z |
| format | Article |
| id | doaj.art-8588cdc232a941818fce3e8c888db571 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-12T08:54:11Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-8588cdc232a941818fce3e8c888db5712022-12-22T03:39:30ZengBMCBiology of Sex Differences2042-64102018-01-01911810.1186/s13293-017-0161-7Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional studyIdo Eisdorfer0Varda Shalev1Sophy Goren2Gabriel Chodick3Khitam Muhsen4Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv UniversityDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv UniversityDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv UniversityDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv UniversityDepartment of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv UniversityAbstract Background Helicobacter pylori causes peptic ulcer disease and gastric cancer only in a subset of infected persons. Sex differences were shown in results of urea breath test (UBT), a commonly used test for the diagnosis of H. pylori infection. However, factors that might explain these differences, or affect UBT values, are not fully understood. We examined differences in UBT values between H. pylori-infected men and women while adjusting for background characteristics such as age, body mass index (BMI), and smoking. Methods A cross-sectional study was undertaken using coded data from the computerized database of Maccabi Health Services in Israel. Included were adults examined for UBT during 2002–2012 and were found H. pylori positive (UBT > 3.5‰). Multivariable linear mixed models were performed to assess the relationship between sex and UBT quantitative results, while adjusting for background characteristics. Results A total of 76,403 patients were included (52% of examined patients during the study period). Adjusted mean UBT value was significantly higher in women 33.8‰ (95% CI 33.4, 34.1) than in men 24.9‰ (95% CI 24.5, 25.3). A significant (P < 0.001) interaction was found between sex and smoking, showing diminished sex-differences in UBT results in smokers. Adjusted mean UBT values increased significantly with age and decreased with BMI, and it was higher in people who lived in low vs high socioeconomic status communities and lower in smokers vs non-smokers. Conclusions Systemic differences exist between men and women in quantitative UBT results. Host-related and environmental factors might affect UBT quantitative results. These findings have clinical implications regarding confirmation of the success of H. pylori eradication after treatment in various subgroups.http://link.springer.com/article/10.1186/s13293-017-0161-7H. pylori infectionUrea breath testSex differencesSmoking |
| spellingShingle | Ido Eisdorfer Varda Shalev Sophy Goren Gabriel Chodick Khitam Muhsen Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study Biology of Sex Differences H. pylori infection Urea breath test Sex differences Smoking |
| title | Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study |
| title_full | Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study |
| title_fullStr | Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study |
| title_full_unstemmed | Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study |
| title_short | Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study |
| title_sort | sex differences in urea breath test results for the diagnosis of helicobacter pylori infection a large cross sectional study |
| topic | H. pylori infection Urea breath test Sex differences Smoking |
| url | http://link.springer.com/article/10.1186/s13293-017-0161-7 |
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