The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and Methodology
<b>Background</b>. Each year, approximately 5000 New Zealanders are admitted to hospital with first-time acute coronary syndrome (ACS). <i>The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes</i> (MENZACS) is a prospective longitudinal cohort study embedded within t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cardiogenetics |
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| Online Access: | https://www.mdpi.com/2035-8148/11/2/10 |
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| author | Malcolm. E. Legget Vicky. A. Cameron Katrina. K. Poppe Sara Aish Nikki Earle Yeunhyang Choi Kathryn. E. Bradbury Clare Wall Ralph Stewart Andrew Kerr Wil Harrison Gerry Devlin Richard Troughton A. Mark Richards Graeme Porter Patrick Gladding Anna Rolleston Robert N. Doughty |
| author_facet | Malcolm. E. Legget Vicky. A. Cameron Katrina. K. Poppe Sara Aish Nikki Earle Yeunhyang Choi Kathryn. E. Bradbury Clare Wall Ralph Stewart Andrew Kerr Wil Harrison Gerry Devlin Richard Troughton A. Mark Richards Graeme Porter Patrick Gladding Anna Rolleston Robert N. Doughty |
| author_sort | Malcolm. E. Legget |
| collection | DOAJ |
| description | <b>Background</b>. Each year, approximately 5000 New Zealanders are admitted to hospital with first-time acute coronary syndrome (ACS). <i>The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes</i> (MENZACS) is a prospective longitudinal cohort study embedded within the All New Zealand Acute Coronary Syndrome Quality Improvement (ANZACS-QI) registry in six hospitals. The objective of MENZACS is to examine the relationship between clinical, genomic, and cardiometabolic markers in relation to presentation and outcomes post-ACS. <b>Methods</b>. Patients with first-time ACS are enrolled and study-specific research data is collected alongside the ANZACS-QI registry. The research blood samples are stored for future genetic/biomarker assays. Dietary information is collected with a food frequency questionnaire and information about physical activity, smoking, and stress is also collected via questionnaire. Detailed family history, ancestry, and ethnicity data are recorded on all participants. <b>Results</b>. During the period between 2015 and 2019, there were 2015 patients enrolled. The mean age was 61 years, with 60% of patients aged <65 years and 21% were female. Ethnicity and cardiovascular (CV) risk factor distribution was similar to ANZACS-QI: 13% Māori, 5% Pacific, 5% Indian, and 74% NZ European. In terms of CV risk factors, 56% were ex-/current smokers, 42% had hypertension, and 19% had diabetes. ACS subtype was ST elevation myocardial infarction (STEMI) in 41%, non-ST elevation myocardial infarction (NSTEM) in 54%, and unstable angina in 5%. Ninety-nine percent of MENZACS participants underwent coronary angiography and 90% had revascularization; there were high rates of prescription of secondary prevention medications upon discharge from hospital. <b>Conclusion</b>. MENZACS represents a cohort with optimal contemporary management and will be a significant epidemiological bioresource for the study of environmental and genetic factors contributing to ACS in New Zealand’s multi-ethnic environment. The study will utilise clinical, nutritional, lifestyle, genomic, and biomarker analyses to explore factors influencing the progression of coronary disease and develop risk prediction models for health outcomes. |
| first_indexed | 2024-03-10T10:37:14Z |
| format | Article |
| id | doaj.art-858a9a21827142aa842babd0a18af6c3 |
| institution | Directory Open Access Journal |
| issn | 2035-8253 2035-8148 |
| language | English |
| last_indexed | 2024-03-10T10:37:14Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cardiogenetics |
| spelling | doaj.art-858a9a21827142aa842babd0a18af6c32023-11-21T23:15:34ZengMDPI AGCardiogenetics2035-82532035-81482021-06-01112849710.3390/cardiogenetics11020010The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and MethodologyMalcolm. E. Legget0Vicky. A. Cameron1Katrina. K. Poppe2Sara Aish3Nikki Earle4Yeunhyang Choi5Kathryn. E. Bradbury6Clare Wall7Ralph Stewart8Andrew Kerr9Wil Harrison10Gerry Devlin11Richard Troughton12A. Mark Richards13Graeme Porter14Patrick Gladding15Anna Rolleston16Robert N. Doughty17Heart Health Research Group, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New ZealandChristchurch Heart Institute, University of Otago, Christchurch 8011, New ZealandHeart Health Research Group, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New ZealandHeart Health Research Group, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New ZealandHeart Health Research Group, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New ZealandHeart Health Research Group, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New ZealandNational Institute for Health Innovation, School of Population Health, University of Auckland, Auckland 1023, New ZealandDiscipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New ZealandGreenlane Cardiovascular Service, Auckland City Hospital, Auckland 1023, New ZealandEpidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New ZealandMiddlemore Hospital, Counties Manukau District Health Board, Auckland 2025, New ZealandGisborne Hospital, Tairawhiti District Health Board, Gisborne 4010, New ZealandChristchurch Heart Institute, University of Otago, Christchurch 8011, New ZealandChristchurch Heart Institute, University of Otago, Christchurch 8011, New ZealandTauranga Hospital, Bay of Plenty District Health Board, Tauranga 3112, New ZealandNorth Shore Hospital, Waitemata District Health Board, Auckland 0620, New ZealandHeart Health Research Group, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New ZealandHeart Health Research Group, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand<b>Background</b>. Each year, approximately 5000 New Zealanders are admitted to hospital with first-time acute coronary syndrome (ACS). <i>The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes</i> (MENZACS) is a prospective longitudinal cohort study embedded within the All New Zealand Acute Coronary Syndrome Quality Improvement (ANZACS-QI) registry in six hospitals. The objective of MENZACS is to examine the relationship between clinical, genomic, and cardiometabolic markers in relation to presentation and outcomes post-ACS. <b>Methods</b>. Patients with first-time ACS are enrolled and study-specific research data is collected alongside the ANZACS-QI registry. The research blood samples are stored for future genetic/biomarker assays. Dietary information is collected with a food frequency questionnaire and information about physical activity, smoking, and stress is also collected via questionnaire. Detailed family history, ancestry, and ethnicity data are recorded on all participants. <b>Results</b>. During the period between 2015 and 2019, there were 2015 patients enrolled. The mean age was 61 years, with 60% of patients aged <65 years and 21% were female. Ethnicity and cardiovascular (CV) risk factor distribution was similar to ANZACS-QI: 13% Māori, 5% Pacific, 5% Indian, and 74% NZ European. In terms of CV risk factors, 56% were ex-/current smokers, 42% had hypertension, and 19% had diabetes. ACS subtype was ST elevation myocardial infarction (STEMI) in 41%, non-ST elevation myocardial infarction (NSTEM) in 54%, and unstable angina in 5%. Ninety-nine percent of MENZACS participants underwent coronary angiography and 90% had revascularization; there were high rates of prescription of secondary prevention medications upon discharge from hospital. <b>Conclusion</b>. MENZACS represents a cohort with optimal contemporary management and will be a significant epidemiological bioresource for the study of environmental and genetic factors contributing to ACS in New Zealand’s multi-ethnic environment. The study will utilise clinical, nutritional, lifestyle, genomic, and biomarker analyses to explore factors influencing the progression of coronary disease and develop risk prediction models for health outcomes.https://www.mdpi.com/2035-8148/11/2/10MENZACSacute coronary syndromemulti-ethnicgenomicsstudy design |
| spellingShingle | Malcolm. E. Legget Vicky. A. Cameron Katrina. K. Poppe Sara Aish Nikki Earle Yeunhyang Choi Kathryn. E. Bradbury Clare Wall Ralph Stewart Andrew Kerr Wil Harrison Gerry Devlin Richard Troughton A. Mark Richards Graeme Porter Patrick Gladding Anna Rolleston Robert N. Doughty The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and Methodology Cardiogenetics MENZACS acute coronary syndrome multi-ethnic genomics study design |
| title | The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and Methodology |
| title_full | The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and Methodology |
| title_fullStr | The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and Methodology |
| title_full_unstemmed | The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and Methodology |
| title_short | The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and Methodology |
| title_sort | multi ethnic new zealand study of acute coronary syndromes menzacs design and methodology |
| topic | MENZACS acute coronary syndrome multi-ethnic genomics study design |
| url | https://www.mdpi.com/2035-8148/11/2/10 |
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