MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, pr...

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Bibliografiske detaljer
Main Authors: Tessa M Popay, Jing Wang, Clare M Adams, Gregory Caleb Howard, Simona G Codreanu, Stacy D Sherrod, John A McLean, Lance R Thomas, Shelly L Lorey, Yuichi J Machida, April M Weissmiller, Christine M Eischen, Qi Liu, William P Tansey
Format: Article
Sprog:English
Udgivet: eLife Sciences Publications Ltd 2021-01-01
Serier:eLife
Fag:
cancer
MYC
ribosome biogenesis
Online adgang:https://elifesciences.org/articles/60191

Internet

https://elifesciences.org/articles/60191

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