MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, pr...

Descrizione completa

Dettagli Bibliografici
Autori principali: Tessa M Popay, Jing Wang, Clare M Adams, Gregory Caleb Howard, Simona G Codreanu, Stacy D Sherrod, John A McLean, Lance R Thomas, Shelly L Lorey, Yuichi J Machida, April M Weissmiller, Christine M Eischen, Qi Liu, William P Tansey
Natura: Articolo
Lingua:English
Pubblicazione: eLife Sciences Publications Ltd 2021-01-01
Serie:eLife
Soggetti:
cancer
MYC
ribosome biogenesis
Accesso online:https://elifesciences.org/articles/60191

Accesso online

https://elifesciences.org/articles/60191

Documenti analoghi