MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, pr...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Tessa M Popay, Jing Wang, Clare M Adams, Gregory Caleb Howard, Simona G Codreanu, Stacy D Sherrod, John A McLean, Lance R Thomas, Shelly L Lorey, Yuichi J Machida, April M Weissmiller, Christine M Eischen, Qi Liu, William P Tansey
Format: Artykuł
Język:English
Wydane: eLife Sciences Publications Ltd 2021-01-01
Seria:eLife
Hasła przedmiotowe:
cancer
MYC
ribosome biogenesis
Dostęp online:https://elifesciences.org/articles/60191

Internet

https://elifesciences.org/articles/60191

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