MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, pr...

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Detalhes bibliográficos
Principais autores: Tessa M Popay, Jing Wang, Clare M Adams, Gregory Caleb Howard, Simona G Codreanu, Stacy D Sherrod, John A McLean, Lance R Thomas, Shelly L Lorey, Yuichi J Machida, April M Weissmiller, Christine M Eischen, Qi Liu, William P Tansey
Formato: Artigo
Idioma:English
Publicado em: eLife Sciences Publications Ltd 2021-01-01
coleção:eLife
Assuntos:
cancer
MYC
ribosome biogenesis
Acesso em linha:https://elifesciences.org/articles/60191

Internet

https://elifesciences.org/articles/60191

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