MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, pr...

Полное описание

Библиографические подробности
Главные авторы: Tessa M Popay, Jing Wang, Clare M Adams, Gregory Caleb Howard, Simona G Codreanu, Stacy D Sherrod, John A McLean, Lance R Thomas, Shelly L Lorey, Yuichi J Machida, April M Weissmiller, Christine M Eischen, Qi Liu, William P Tansey
Формат: Статья
Язык:English
Опубликовано: eLife Sciences Publications Ltd 2021-01-01
Серии:eLife
Предметы:
cancer
MYC
ribosome biogenesis
Online-ссылка:https://elifesciences.org/articles/60191

Internet

https://elifesciences.org/articles/60191

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