Targeting Pericytes for Vascular Normalization as an Emerging Strategy in Remodeling Tumor Microenvironment
Recent studies demonstrate that, the close interactions between pericytes (PCs) and various cells (such as cancer cells, stromal cells and immune cells) in tumor microenvironment (TME) can build an immunosuppressive TME to favor cancer growth and progression by modulating tumor angiogenesis and dysf...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2022-11-01
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| Series: | Zhongguo quanke yixue |
| Subjects: | |
| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220364.pdf |
| _version_ | 1797216906658185216 |
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| author | LAO Shen, HE Jianxing, LIANG Wenhua |
| author_facet | LAO Shen, HE Jianxing, LIANG Wenhua |
| author_sort | LAO Shen, HE Jianxing, LIANG Wenhua |
| collection | DOAJ |
| description | Recent studies demonstrate that, the close interactions between pericytes (PCs) and various cells (such as cancer cells, stromal cells and immune cells) in tumor microenvironment (TME) can build an immunosuppressive TME to favor cancer growth and progression by modulating tumor angiogenesis and dysfunction via abnormal paracrine signaling pathways. In this review, we focused on recent advances in non-small-cell-lung-cancer to understand the regulatory role of PCs in TME and discussed the potential value of targeting PCs for inhibiting tumor angiogenesis and normalizing tumor vasculature to remodel TME, indicating that we can break through the dilemma of combined anti vascular therapy for solid tumors at this stage by targeting the normalization of tumor blood vessels of PCs. This may be a new strategy that could be used combinedly to improve chemotherapy, small molecule inhibitor targeted therapy or immune checkpoint inhibitor therapy. |
| first_indexed | 2024-04-24T11:53:24Z |
| format | Article |
| id | doaj.art-858d665008f14b838a96a17a730efd3d |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:53:24Z |
| publishDate | 2022-11-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-858d665008f14b838a96a17a730efd3d2024-04-09T06:17:52ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722022-11-0125323971397710.12114/j.issn.1007-9572.2022.0364Targeting Pericytes for Vascular Normalization as an Emerging Strategy in Remodeling Tumor MicroenvironmentLAO Shen, HE Jianxing, LIANG Wenhua0Department of Thoracic Surgery, the First Affiliated Hospital of Guangzhou Medical University/State Key Laboratory of Respiratory Disease/National Respiratory Medical Center /Guangzhou Institute of Respiratory Health, Guangzhou 510182, ChinaRecent studies demonstrate that, the close interactions between pericytes (PCs) and various cells (such as cancer cells, stromal cells and immune cells) in tumor microenvironment (TME) can build an immunosuppressive TME to favor cancer growth and progression by modulating tumor angiogenesis and dysfunction via abnormal paracrine signaling pathways. In this review, we focused on recent advances in non-small-cell-lung-cancer to understand the regulatory role of PCs in TME and discussed the potential value of targeting PCs for inhibiting tumor angiogenesis and normalizing tumor vasculature to remodel TME, indicating that we can break through the dilemma of combined anti vascular therapy for solid tumors at this stage by targeting the normalization of tumor blood vessels of PCs. This may be a new strategy that could be used combinedly to improve chemotherapy, small molecule inhibitor targeted therapy or immune checkpoint inhibitor therapy.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220364.pdftumor microenvironment|pericytes|molecular targeted therapy|normalizing tumor vasculature|immunomodulation|review |
| spellingShingle | LAO Shen, HE Jianxing, LIANG Wenhua Targeting Pericytes for Vascular Normalization as an Emerging Strategy in Remodeling Tumor Microenvironment Zhongguo quanke yixue tumor microenvironment|pericytes|molecular targeted therapy|normalizing tumor vasculature|immunomodulation|review |
| title | Targeting Pericytes for Vascular Normalization as an Emerging Strategy in Remodeling Tumor Microenvironment |
| title_full | Targeting Pericytes for Vascular Normalization as an Emerging Strategy in Remodeling Tumor Microenvironment |
| title_fullStr | Targeting Pericytes for Vascular Normalization as an Emerging Strategy in Remodeling Tumor Microenvironment |
| title_full_unstemmed | Targeting Pericytes for Vascular Normalization as an Emerging Strategy in Remodeling Tumor Microenvironment |
| title_short | Targeting Pericytes for Vascular Normalization as an Emerging Strategy in Remodeling Tumor Microenvironment |
| title_sort | targeting pericytes for vascular normalization as an emerging strategy in remodeling tumor microenvironment |
| topic | tumor microenvironment|pericytes|molecular targeted therapy|normalizing tumor vasculature|immunomodulation|review |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220364.pdf |
| work_keys_str_mv | AT laoshenhejianxingliangwenhua targetingpericytesforvascularnormalizationasanemergingstrategyinremodelingtumormicroenvironment |