Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model

Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model

Abstract Background Animal models of spontaneous osteoarthritis (OA) are sparse and not well characterized. The purpose of the present study is to examine OA-related changes and mechanisms in senescence-accelerated mouse prone 8 (SAMP8) that displays a phenotype of accelerated aging.  Methods Knees...

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Bibliographic Details
Main Authors: Yohei Sanada, Yasunari Ikuta, Chenyang Ding, Masahiro Shinohara, Dilimulati Yimiti, Hiroyuki Ishitobi, Keita Nagira, Minjung Lee, Takayuki Akimoto, Sachi Shibata, Masakazu Ishikawa, Tomoyuki Nakasa, Kiminori Matsubara, Martin K. Lotz, Nobuo Adachi, Shigeru Miyaki
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Aging
Mouse models
Subchondral bone
Meniscus
Online Access:https://doi.org/10.1186/s13075-022-02916-5

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