Depletion of Microglia in an Ex Vivo Brain Slice Culture Model of West Nile Virus Infection Leads to Increased Viral Titers and Cell Death

Depletion of Microglia in an Ex Vivo Brain Slice Culture Model of West Nile Virus Infection Leads to Increased Viral Titers and Cell Death

ABSTRACT West Nile virus (WNV) is a major cause of viral encephalitis in the United States. WNV infection of the brain leads to neuroinflammation characterized by activation of microglia, the resident phagocytic cells of the central nervous system (CNS). In this study, depletion of CNS microglia usi...

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Bibliographic Details
Main Authors: Sarah Stonedahl, Jennifer Smith Leser, Penny Clarke, Kenneth L. Tyler
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
West Nile virus
microglia
viral pathogenesis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00685-22

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