Serum S100B: A possible biomarker for severity of obstructive sleep apnea
Introduction: Obstructive sleep apnea (OSA) is characterized by upper airway collapsibility and intermittent hypoxia (IH) during sleep. It has neurological complications and it has been associated with morbidity and mortality. Increased serum levels of S100B protein indicates brain injury. Early det...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-10-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763817301711 |
| _version_ | 1819114836483637248 |
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| author | Eman Riad Mohammad Nasser Mohammad H. Hussein Eman A. Toraih Manal S. Fawzy |
| author_facet | Eman Riad Mohammad Nasser Mohammad H. Hussein Eman A. Toraih Manal S. Fawzy |
| author_sort | Eman Riad |
| collection | DOAJ |
| description | Introduction: Obstructive sleep apnea (OSA) is characterized by upper airway collapsibility and intermittent hypoxia (IH) during sleep. It has neurological complications and it has been associated with morbidity and mortality. Increased serum levels of S100B protein indicates brain injury. Early detection of possible complications of OSA patients could improve management of the disease.
Study objective: Measurement of serum S100B protein in OSA patients with correlation to the severity of the disease.
Patients and methods: Fifty five OSA patients (24 females; 43.6% and 31 males; 56.4%) and 34 control individuals (17 females; 50% and 17 males; 50%) had a sleep apnea monitoring using the SAM equipment, Inter care technologies, model 100, USA, and S100B serum levels were measured after the sleep study at 6.30–7.30 am.
Results: S100B serum levels were higher in patients than controls (P < 0.001) and the levels correlated with the apnea/hypopnea index (AHI) (P < 0.001), lowest oxygen saturation (LOS) (P < 0.001), and oxygen desaturation index (ODI) (P < 0.001).
Conclusion: Serum S100B protein was significantly elevated in OSA patients and its serum levels correlated with the severity of the disease. Increased serum S100B could indicat brain injury and could be a potential serum biomarker for detection of early neurological complications in OSA patients that could improve the management and care of these patients. |
| first_indexed | 2024-12-22T04:51:38Z |
| format | Article |
| id | doaj.art-858fa67d649544b39ff5fb667e2e4293 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-12-22T04:51:38Z |
| publishDate | 2017-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-858fa67d649544b39ff5fb667e2e42932022-12-21T18:38:29ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382017-10-0166463964310.1016/j.ejcdt.2017.07.003Serum S100B: A possible biomarker for severity of obstructive sleep apneaEman Riad0Mohammad Nasser1Mohammad H. Hussein2Eman A. Toraih3Manal S. Fawzy4Department of Chest Diseases and Tuberculosis, Faculty of Medicine, Suez Canal University, Ismailia P.O. 41522, EgyptDepartment of Chest Diseases and Tuberculosis, Faculty of Medicine, Suez Canal University, Ismailia P.O. 41522, EgyptPulmonologist, Ministry of Health, Cairo, EgyptDepartment of Histology and Cell Biology (Genetics Unit), Faculty of Medicine, Suez Canal University, Ismailia, EgyptDepartment of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, EgyptIntroduction: Obstructive sleep apnea (OSA) is characterized by upper airway collapsibility and intermittent hypoxia (IH) during sleep. It has neurological complications and it has been associated with morbidity and mortality. Increased serum levels of S100B protein indicates brain injury. Early detection of possible complications of OSA patients could improve management of the disease. Study objective: Measurement of serum S100B protein in OSA patients with correlation to the severity of the disease. Patients and methods: Fifty five OSA patients (24 females; 43.6% and 31 males; 56.4%) and 34 control individuals (17 females; 50% and 17 males; 50%) had a sleep apnea monitoring using the SAM equipment, Inter care technologies, model 100, USA, and S100B serum levels were measured after the sleep study at 6.30–7.30 am. Results: S100B serum levels were higher in patients than controls (P < 0.001) and the levels correlated with the apnea/hypopnea index (AHI) (P < 0.001), lowest oxygen saturation (LOS) (P < 0.001), and oxygen desaturation index (ODI) (P < 0.001). Conclusion: Serum S100B protein was significantly elevated in OSA patients and its serum levels correlated with the severity of the disease. Increased serum S100B could indicat brain injury and could be a potential serum biomarker for detection of early neurological complications in OSA patients that could improve the management and care of these patients.http://www.sciencedirect.com/science/article/pii/S0422763817301711Apnea/hypopnea indexObstructive sleep apneaS100BLowest oxygen saturationOxygen desaturation indexEgyptian |
| spellingShingle | Eman Riad Mohammad Nasser Mohammad H. Hussein Eman A. Toraih Manal S. Fawzy Serum S100B: A possible biomarker for severity of obstructive sleep apnea Egyptian Journal of Chest Disease and Tuberculosis Apnea/hypopnea index Obstructive sleep apnea S100B Lowest oxygen saturation Oxygen desaturation index Egyptian |
| title | Serum S100B: A possible biomarker for severity of obstructive sleep apnea |
| title_full | Serum S100B: A possible biomarker for severity of obstructive sleep apnea |
| title_fullStr | Serum S100B: A possible biomarker for severity of obstructive sleep apnea |
| title_full_unstemmed | Serum S100B: A possible biomarker for severity of obstructive sleep apnea |
| title_short | Serum S100B: A possible biomarker for severity of obstructive sleep apnea |
| title_sort | serum s100b a possible biomarker for severity of obstructive sleep apnea |
| topic | Apnea/hypopnea index Obstructive sleep apnea S100B Lowest oxygen saturation Oxygen desaturation index Egyptian |
| url | http://www.sciencedirect.com/science/article/pii/S0422763817301711 |
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