Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
Objective To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status.Methods This was an observational, cross-sectional and multicentre study with patients who fulfilled the European Spondyloarthropathy Study Group cri...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-07-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/9/3/e003235.full |
| _version_ | 1797640275696287744 |
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| author | Jordi Gratacós Clementina López-Medina Janitzia Vázquez-Mellado Eduardo Collantes-Estevez Alejandro Escudero-Contreras Xavier Juanola Pilar Font-Ugalde María Ángeles Puche-Larrubia Lourdes Ladehesa-Pineda |
| author_facet | Jordi Gratacós Clementina López-Medina Janitzia Vázquez-Mellado Eduardo Collantes-Estevez Alejandro Escudero-Contreras Xavier Juanola Pilar Font-Ugalde María Ángeles Puche-Larrubia Lourdes Ladehesa-Pineda |
| author_sort | Jordi Gratacós |
| collection | DOAJ |
| description | Objective To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status.Methods This was an observational, cross-sectional and multicentre study with patients who fulfilled the European Spondyloarthropathy Study Group criteria for SpA from the Registry of Spondyloarthritis of Spanish Rheumatology (REGISPONSER) and Ibero-American Registry of Spondyloarthropathies (RESPONDIA) united registries. Differences in the first sign(s) or symptom(s) were compared across diagnoses and between HLA-B27 status. The diagnostic delay between patients who start the disease with musculoskeletal manifestations (MMs) and extra-MMs (EMMs) was compared.Results A total of 4067 patients were included (2208 from REGISPONSER and 1859 from RESPONDIA) (ankylosing spondylitis (AS): 68.3%, psoriatic arthritis (PsA): 19.9%, undifferentiated SpA: 11.8%). Overall, 3624 (89.1%) patients initiated the disease with MMs and 443 (10.9%) with EMMs. Low back pain (61.7%) and lower-limb arthritis (38.5%) were the most frequent initial symptoms. In AS patients, the absence of HLA-B27 seems to be related to an increase in the probability of starting the disease with cervical pain and peripheral manifestations. In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. The diagnostic delay was longer in patients with initial MMs than in those with EMMs (7.2 (34.8) vs 4.5 (7.6) years, respectively).Conclusion In this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen. |
| first_indexed | 2024-03-11T13:29:33Z |
| format | Article |
| id | doaj.art-85921cbeb4c44521850d6724aab214d1 |
| institution | Directory Open Access Journal |
| issn | 2056-5933 |
| language | English |
| last_indexed | 2024-03-11T13:29:33Z |
| publishDate | 2023-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj.art-85921cbeb4c44521850d6724aab214d12023-11-03T03:20:08ZengBMJ Publishing GroupRMD Open2056-59332023-07-019310.1136/rmdopen-2023-003235Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registriesJordi Gratacós0Clementina López-Medina1Janitzia Vázquez-Mellado2Eduardo Collantes-Estevez3Alejandro Escudero-Contreras4Xavier Juanola5Pilar Font-Ugalde6María Ángeles Puche-Larrubia7Lourdes Ladehesa-Pineda8Department of Rheumatology, Hospital Universitario Parc Taulí, Barcelona, SpainDepartment of Rheumatology, Reina Sofia University Hospital, Cordoba, SpainDepartment of Rheumatology, Hospital General de Mexico, Mexico City, MexicoGC-05 Group, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Cordoba, SpainMedical and Surgical Sciences, University of Cordoba, Cordoba, SpainDepartment of Rheumatology, Hospital Universitari de Bellvitge, Barcelona, SpainGC-05 Group, Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Cordoba, SpainDepartment of Rheumatology, Reina Sofia University Hospital, Cordoba, SpainDepartment of Rheumatology, Reina Sofia University Hospital, Cordoba, SpainObjective To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status.Methods This was an observational, cross-sectional and multicentre study with patients who fulfilled the European Spondyloarthropathy Study Group criteria for SpA from the Registry of Spondyloarthritis of Spanish Rheumatology (REGISPONSER) and Ibero-American Registry of Spondyloarthropathies (RESPONDIA) united registries. Differences in the first sign(s) or symptom(s) were compared across diagnoses and between HLA-B27 status. The diagnostic delay between patients who start the disease with musculoskeletal manifestations (MMs) and extra-MMs (EMMs) was compared.Results A total of 4067 patients were included (2208 from REGISPONSER and 1859 from RESPONDIA) (ankylosing spondylitis (AS): 68.3%, psoriatic arthritis (PsA): 19.9%, undifferentiated SpA: 11.8%). Overall, 3624 (89.1%) patients initiated the disease with MMs and 443 (10.9%) with EMMs. Low back pain (61.7%) and lower-limb arthritis (38.5%) were the most frequent initial symptoms. In AS patients, the absence of HLA-B27 seems to be related to an increase in the probability of starting the disease with cervical pain and peripheral manifestations. In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. The diagnostic delay was longer in patients with initial MMs than in those with EMMs (7.2 (34.8) vs 4.5 (7.6) years, respectively).Conclusion In this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen.https://rmdopen.bmj.com/content/9/3/e003235.full |
| spellingShingle | Jordi Gratacós Clementina López-Medina Janitzia Vázquez-Mellado Eduardo Collantes-Estevez Alejandro Escudero-Contreras Xavier Juanola Pilar Font-Ugalde María Ángeles Puche-Larrubia Lourdes Ladehesa-Pineda Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries RMD Open |
| title | Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries |
| title_full | Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries |
| title_fullStr | Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries |
| title_full_unstemmed | Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries |
| title_short | Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries |
| title_sort | identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with hla b27 data from regisponser and respondia registries |
| url | https://rmdopen.bmj.com/content/9/3/e003235.full |
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