Risk factors and the CCTA application in patients with vulnerable coronary plaque in type 2 diabetes: a retrospective study
Abstract Background Diabetes is an independent risk factor for cardiovascular disease. The purpose of this study was to identify the risk factors for vulnerable coronary plaques (VCPs), which are associated with adverse cardiovascular events, and to determine the value of coronary CT angiography (CC...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-03717-1 |
| _version_ | 1797275994713751552 |
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| author | Weihong He Tingsong Fang Xi Fu Meiling Lao Xiuyun Xiao |
| author_facet | Weihong He Tingsong Fang Xi Fu Meiling Lao Xiuyun Xiao |
| author_sort | Weihong He |
| collection | DOAJ |
| description | Abstract Background Diabetes is an independent risk factor for cardiovascular disease. The purpose of this study was to identify the risk factors for vulnerable coronary plaques (VCPs), which are associated with adverse cardiovascular events, and to determine the value of coronary CT angiography (CCTA) in patients with type 2 diabetes mellitus (T2DM) and VCPs. Methods Ninety-eight T2DM patients who underwent CCTA and intravascular ultrasound (IVUS) were retrospectively included and analyzed. The patients were grouped and analyzed according to the presence or absence of VCPs. Results Among the patients with T2DM, time in range [TIR {the percentage of time blood glucose levels were in the target range}] (OR = 0.93, 95% CI = 0.89–0.96; P < 0.001) and the high-density lipoprotein-cholesterol (HDL-C) concentration (OR = 0.24, 95% CI = 0.09–0.63; P = 0.04) were correlated with a lower risk of VCP, but the triglycerides (TG) concentration was correlated with a higher risk of VCP (OR = 1.79, 95% CI = 1.01–3.18; P = 0.045). The area under the receiver operator characteristic curve (AUC) of TIR, and HDL-C and TG concentrations were 0.76, 0.73, and 0.65, respectively. The combined predicted AUC of TIR, and HDL-C and TG concentrations was 0.83 (P < 0.05). The CCTA sensitivity, specificity, false-negative, and false-positive values for the diagnosis of VCP were 95.74%, 94.12%, 4.26%, and 5.88%, respectively. The identification of VCP by CCTA was positively correlated with IVUS (intraclass correlation coefficient [ICC] = 0.90). Conclusions The TIR and HDL-C concentration are related with lower risk of VCP and the TG concentration was related with higher risk of VCP in patients with T2DM. In clinical practice, TIR, HDL-C and TG need special attention in patients with T2DM. The ability of CCTA to identify VCP is highly related to IVUS findings. |
| first_indexed | 2024-03-07T15:21:03Z |
| format | Article |
| id | doaj.art-8592601a4f9a4c2a88ac7a1205889737 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-07T15:21:03Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-8592601a4f9a4c2a88ac7a12058897372024-03-05T17:37:40ZengBMCBMC Cardiovascular Disorders1471-22612024-02-0124111010.1186/s12872-024-03717-1Risk factors and the CCTA application in patients with vulnerable coronary plaque in type 2 diabetes: a retrospective studyWeihong He0Tingsong Fang1Xi Fu2Meiling Lao3Xiuyun Xiao4Department of Radiology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese MedicineDepartment of Radiology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese MedicineDepartment of Radiology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese MedicineDepartment of Endocrinology, Foshan Hospital of Traditional Chinese Medicine， Guangzhou University of Traditional Chinese MedicineDepartment of Radiology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese MedicineAbstract Background Diabetes is an independent risk factor for cardiovascular disease. The purpose of this study was to identify the risk factors for vulnerable coronary plaques (VCPs), which are associated with adverse cardiovascular events, and to determine the value of coronary CT angiography (CCTA) in patients with type 2 diabetes mellitus (T2DM) and VCPs. Methods Ninety-eight T2DM patients who underwent CCTA and intravascular ultrasound (IVUS) were retrospectively included and analyzed. The patients were grouped and analyzed according to the presence or absence of VCPs. Results Among the patients with T2DM, time in range [TIR {the percentage of time blood glucose levels were in the target range}] (OR = 0.93, 95% CI = 0.89–0.96; P < 0.001) and the high-density lipoprotein-cholesterol (HDL-C) concentration (OR = 0.24, 95% CI = 0.09–0.63; P = 0.04) were correlated with a lower risk of VCP, but the triglycerides (TG) concentration was correlated with a higher risk of VCP (OR = 1.79, 95% CI = 1.01–3.18; P = 0.045). The area under the receiver operator characteristic curve (AUC) of TIR, and HDL-C and TG concentrations were 0.76, 0.73, and 0.65, respectively. The combined predicted AUC of TIR, and HDL-C and TG concentrations was 0.83 (P < 0.05). The CCTA sensitivity, specificity, false-negative, and false-positive values for the diagnosis of VCP were 95.74%, 94.12%, 4.26%, and 5.88%, respectively. The identification of VCP by CCTA was positively correlated with IVUS (intraclass correlation coefficient [ICC] = 0.90). Conclusions The TIR and HDL-C concentration are related with lower risk of VCP and the TG concentration was related with higher risk of VCP in patients with T2DM. In clinical practice, TIR, HDL-C and TG need special attention in patients with T2DM. The ability of CCTA to identify VCP is highly related to IVUS findings.https://doi.org/10.1186/s12872-024-03717-1Type 2 diabetes mellitusVulnerable coronary plaqueCT angiographyIntravascular ultrasound |
| spellingShingle | Weihong He Tingsong Fang Xi Fu Meiling Lao Xiuyun Xiao Risk factors and the CCTA application in patients with vulnerable coronary plaque in type 2 diabetes: a retrospective study BMC Cardiovascular Disorders Type 2 diabetes mellitus Vulnerable coronary plaque CT angiography Intravascular ultrasound |
| title | Risk factors and the CCTA application in patients with vulnerable coronary plaque in type 2 diabetes: a retrospective study |
| title_full | Risk factors and the CCTA application in patients with vulnerable coronary plaque in type 2 diabetes: a retrospective study |
| title_fullStr | Risk factors and the CCTA application in patients with vulnerable coronary plaque in type 2 diabetes: a retrospective study |
| title_full_unstemmed | Risk factors and the CCTA application in patients with vulnerable coronary plaque in type 2 diabetes: a retrospective study |
| title_short | Risk factors and the CCTA application in patients with vulnerable coronary plaque in type 2 diabetes: a retrospective study |
| title_sort | risk factors and the ccta application in patients with vulnerable coronary plaque in type 2 diabetes a retrospective study |
| topic | Type 2 diabetes mellitus Vulnerable coronary plaque CT angiography Intravascular ultrasound |
| url | https://doi.org/10.1186/s12872-024-03717-1 |
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