Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis
Sung Ryul Yu,1 Kyung-A Shin2 1Department of Clinical Laboratory Science, Semyung University, Jaecheon, Republic of Korea; 2Department of Clinical Laboratory Science, Shinsung University, Dangjin, Republic of KoreaCorrespondence: Kyung-A Shin, Department of Clinical Laboratory Science, Shinsung Unive...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/visceral-adiposity-index-and-lipid-accumulation-product-as-effective-m-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797903182505967616 |
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| author | Yu SR Shin KA |
| author_facet | Yu SR Shin KA |
| author_sort | Yu SR |
| collection | DOAJ |
| description | Sung Ryul Yu,1 Kyung-A Shin2 1Department of Clinical Laboratory Science, Semyung University, Jaecheon, Republic of Korea; 2Department of Clinical Laboratory Science, Shinsung University, Dangjin, Republic of KoreaCorrespondence: Kyung-A Shin, Department of Clinical Laboratory Science, Shinsung University, Daehak-ro 1, Jeongmi-myeon, Dangjin, Chungnam, 31801, Republic of Korea, Tel +82-41-350-1408, Fax +82-41-350-1045, Email mobitz2@hanmail.netPurpose: The visceral adiposity index (VAI) and lipid accumulation product (LAP) are useful for assessing visceral obesity. However, these indices were developed for Caucasians, and it is necessary to confirm whether the VAI and LAP are appropriate indicators for identifying obesity phenotypes in Asians. This study investigated whether the VAI and LAP are effective indicators for diagnosing four obesity phenotypes in South Korean adults.Patients and Methods: This cross-sectional study enrolled 23,310 adult participants (age ≥ 20 years) who had undergone a health checkup at a general hospital in Gyeonggi-do, South Korea from January 2017 to December 2020. VAI and LAP were calculated based on the presented mathematical model according to sex. According to the metabolic health status and presence or absence of obesity, the obesity phenotypes were classified into 4 groups: metabolically healthy non-obese (N=14,240, 61.1%), metabolically unhealthy non-obese (N=477, 2.0%), metabolically healthy obese (MHO; N=6796, 29.2%), and metabolically unhealthy obesity (MUO; N=1797, 7.7%).Results: The receiver operating characteristics curve analysis showed VAI best predicted MUO among the four obesity phenotypes, whereas the LAP showed excellent discriminating ability for the MUO group (area under the curve 0.877, 0.849, and 0.921 and 0.923, 0.907, and 0.954 for all participants, men, and women, respectively). The optimal VAI cutoff values for identifying the MUO group were 1.83 in men and 1.58 in women, and the optimal cutoff values for the LAP were 41.45 in men and 23.83 in women, with a higher value for men. After adjusting for potential confounding factors, the VAI and LAP were associated with an increased risk in the MHO and MUO groups among the obesity phenotypes in both sexes.Conclusion: In South Korean adults, the VAI and LAP are closely related to the MUO phenotype in both sexes and are effective indices for predicting the MUO phenotype.Keywords: lipid accumulation product, visceral adiposity index, metabolic syndrome, obesity phenotype |
| first_indexed | 2024-04-10T09:28:50Z |
| format | Article |
| id | doaj.art-8592baf404f64653804dda9a104da67c |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T09:28:50Z |
| publishDate | 2023-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-8592baf404f64653804dda9a104da67c2023-02-19T13:56:56ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-02-01Volume 1649550481714Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional AnalysisYu SRShin KASung Ryul Yu,1 Kyung-A Shin2 1Department of Clinical Laboratory Science, Semyung University, Jaecheon, Republic of Korea; 2Department of Clinical Laboratory Science, Shinsung University, Dangjin, Republic of KoreaCorrespondence: Kyung-A Shin, Department of Clinical Laboratory Science, Shinsung University, Daehak-ro 1, Jeongmi-myeon, Dangjin, Chungnam, 31801, Republic of Korea, Tel +82-41-350-1408, Fax +82-41-350-1045, Email mobitz2@hanmail.netPurpose: The visceral adiposity index (VAI) and lipid accumulation product (LAP) are useful for assessing visceral obesity. However, these indices were developed for Caucasians, and it is necessary to confirm whether the VAI and LAP are appropriate indicators for identifying obesity phenotypes in Asians. This study investigated whether the VAI and LAP are effective indicators for diagnosing four obesity phenotypes in South Korean adults.Patients and Methods: This cross-sectional study enrolled 23,310 adult participants (age ≥ 20 years) who had undergone a health checkup at a general hospital in Gyeonggi-do, South Korea from January 2017 to December 2020. VAI and LAP were calculated based on the presented mathematical model according to sex. According to the metabolic health status and presence or absence of obesity, the obesity phenotypes were classified into 4 groups: metabolically healthy non-obese (N=14,240, 61.1%), metabolically unhealthy non-obese (N=477, 2.0%), metabolically healthy obese (MHO; N=6796, 29.2%), and metabolically unhealthy obesity (MUO; N=1797, 7.7%).Results: The receiver operating characteristics curve analysis showed VAI best predicted MUO among the four obesity phenotypes, whereas the LAP showed excellent discriminating ability for the MUO group (area under the curve 0.877, 0.849, and 0.921 and 0.923, 0.907, and 0.954 for all participants, men, and women, respectively). The optimal VAI cutoff values for identifying the MUO group were 1.83 in men and 1.58 in women, and the optimal cutoff values for the LAP were 41.45 in men and 23.83 in women, with a higher value for men. After adjusting for potential confounding factors, the VAI and LAP were associated with an increased risk in the MHO and MUO groups among the obesity phenotypes in both sexes.Conclusion: In South Korean adults, the VAI and LAP are closely related to the MUO phenotype in both sexes and are effective indices for predicting the MUO phenotype.Keywords: lipid accumulation product, visceral adiposity index, metabolic syndrome, obesity phenotypehttps://www.dovepress.com/visceral-adiposity-index-and-lipid-accumulation-product-as-effective-m-peer-reviewed-fulltext-article-DMSOlipid accumulation productvisceral adiposity indexmetabolic syndromeobesity phenotype |
| spellingShingle | Yu SR Shin KA Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis Diabetes, Metabolic Syndrome and Obesity lipid accumulation product visceral adiposity index metabolic syndrome obesity phenotype |
| title | Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis |
| title_full | Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis |
| title_fullStr | Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis |
| title_full_unstemmed | Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis |
| title_short | Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis |
| title_sort | visceral adiposity index and lipid accumulation product as effective markers of different obesity phenotypes in korean adults a cross sectional analysis |
| topic | lipid accumulation product visceral adiposity index metabolic syndrome obesity phenotype |
| url | https://www.dovepress.com/visceral-adiposity-index-and-lipid-accumulation-product-as-effective-m-peer-reviewed-fulltext-article-DMSO |
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