Ocular Inflammation Post-Vaccination
The association between vaccines and ocular disorders has attracted significant attention in scientific research. Numerous mainstream vaccines are associated with a range of uveitis types, including anterior, intermediate, and posterior uveitis. Additionally, they are associated with distinct ocular...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/10/1626 |
| _version_ | 1797572120706809856 |
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| author | Yaru Zou Koju Kamoi Yuan Zong Jing Zhang Mingming Yang Kyoko Ohno-Matsui |
| author_facet | Yaru Zou Koju Kamoi Yuan Zong Jing Zhang Mingming Yang Kyoko Ohno-Matsui |
| author_sort | Yaru Zou |
| collection | DOAJ |
| description | The association between vaccines and ocular disorders has attracted significant attention in scientific research. Numerous mainstream vaccines are associated with a range of uveitis types, including anterior, intermediate, and posterior uveitis. Additionally, they are associated with distinct ocular diseases such as multifocal choroiditis, Vogt–Koyanagi–Harada (VKH) disease, acute posterior multifocal placoid pigment epitheliopathy (APMPPE), and multiple evanescent white dot syndrome (MEWDS). These ocular conditions are often transient, with a vast majority of patients experiencing improvement after steroid intervention. To date, numerous cases of vaccine-induced uveitis have been reported. This study analyzed the correlation between antiviral vaccines, including the hepatitis B virus (HBV), human papillomavirus (HPV), measles–mumps–rubella (MMR), varicella zoster virus (VZV), and influenza vaccines, and different manifestations of uveitis. This is the first comprehensive study to offer a detailed analysis of uveitis types induced by antiviral vaccines. Through an extensive database search, we found a particularly strong link between influenza vaccines, followed by VZV and HPV vaccines. While anterior uveitis is common, conditions such as APMPPE, MEWDS, and VKH are particularly notable and merit careful consideration in clinical practice. Corticosteroid treatment was effective; however, half of the observed patients did not achieve full recovery, indicating potentially prolonged effects of the vaccine. |
| first_indexed | 2024-03-10T20:50:00Z |
| format | Article |
| id | doaj.art-85935472149842aca525fd47b0d3b3da |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T20:50:00Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-85935472149842aca525fd47b0d3b3da2023-11-19T18:25:35ZengMDPI AGVaccines2076-393X2023-10-011110162610.3390/vaccines11101626Ocular Inflammation Post-VaccinationYaru Zou0Koju Kamoi1Yuan Zong2Jing Zhang3Mingming Yang4Kyoko Ohno-Matsui5Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, JapanDepartment of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, JapanDepartment of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, JapanDepartment of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, JapanDepartment of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, JapanDepartment of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, JapanThe association between vaccines and ocular disorders has attracted significant attention in scientific research. Numerous mainstream vaccines are associated with a range of uveitis types, including anterior, intermediate, and posterior uveitis. Additionally, they are associated with distinct ocular diseases such as multifocal choroiditis, Vogt–Koyanagi–Harada (VKH) disease, acute posterior multifocal placoid pigment epitheliopathy (APMPPE), and multiple evanescent white dot syndrome (MEWDS). These ocular conditions are often transient, with a vast majority of patients experiencing improvement after steroid intervention. To date, numerous cases of vaccine-induced uveitis have been reported. This study analyzed the correlation between antiviral vaccines, including the hepatitis B virus (HBV), human papillomavirus (HPV), measles–mumps–rubella (MMR), varicella zoster virus (VZV), and influenza vaccines, and different manifestations of uveitis. This is the first comprehensive study to offer a detailed analysis of uveitis types induced by antiviral vaccines. Through an extensive database search, we found a particularly strong link between influenza vaccines, followed by VZV and HPV vaccines. While anterior uveitis is common, conditions such as APMPPE, MEWDS, and VKH are particularly notable and merit careful consideration in clinical practice. Corticosteroid treatment was effective; however, half of the observed patients did not achieve full recovery, indicating potentially prolonged effects of the vaccine.https://www.mdpi.com/2076-393X/11/10/1626vaccinepost-vaccinationimmunizationocular complicationsocular side effectsuveitis |
| spellingShingle | Yaru Zou Koju Kamoi Yuan Zong Jing Zhang Mingming Yang Kyoko Ohno-Matsui Ocular Inflammation Post-Vaccination Vaccines vaccine post-vaccination immunization ocular complications ocular side effects uveitis |
| title | Ocular Inflammation Post-Vaccination |
| title_full | Ocular Inflammation Post-Vaccination |
| title_fullStr | Ocular Inflammation Post-Vaccination |
| title_full_unstemmed | Ocular Inflammation Post-Vaccination |
| title_short | Ocular Inflammation Post-Vaccination |
| title_sort | ocular inflammation post vaccination |
| topic | vaccine post-vaccination immunization ocular complications ocular side effects uveitis |
| url | https://www.mdpi.com/2076-393X/11/10/1626 |
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