Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants?
Glutaredoxins (GRXs) have at least three major identified functions. In apoforms, they exhibit oxidoreductase activity controlling notably protein glutathionylation/deglutathionylation. In holoforms, i.e., iron–sulfur (Fe–S) cluster-bridging forms, they act as maturation factors for the biogenesis o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpls.2019.00712/full |
| _version_ | 1819210765365673984 |
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| author | Pascal Rey Maël Taupin-Broggini Jérémy Couturier Florence Vignols Nicolas Rouhier |
| author_facet | Pascal Rey Maël Taupin-Broggini Jérémy Couturier Florence Vignols Nicolas Rouhier |
| author_sort | Pascal Rey |
| collection | DOAJ |
| description | Glutaredoxins (GRXs) have at least three major identified functions. In apoforms, they exhibit oxidoreductase activity controlling notably protein glutathionylation/deglutathionylation. In holoforms, i.e., iron–sulfur (Fe–S) cluster-bridging forms, they act as maturation factors for the biogenesis of Fe–S proteins or as regulators of iron homeostasis contributing directly or indirectly to the sensing of cellular iron status and/or distribution. The latter functions seem intimately connected with the capacity of specific GRXs to form [2Fe–2S] cluster-bridging homodimeric or heterodimeric complexes with BOLA proteins. In yeast species, both proteins modulate the localization and/or activity of transcription factors regulating genes coding for proteins involved in iron uptake and intracellular sequestration in response notably to iron deficiency. Whereas vertebrate GRX and BOLA isoforms may display similar functions, the involved partner proteins are different. We perform here a critical evaluation of the results supporting the implication of both protein families in similar signaling pathways in plants and provide ideas and experimental strategies to delineate further their functions. |
| first_indexed | 2024-12-23T06:16:23Z |
| format | Article |
| id | doaj.art-85939f7b4f6d48acbaa78efca36fd6d1 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-23T06:16:23Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-85939f7b4f6d48acbaa78efca36fd6d12022-12-21T17:57:17ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2019-06-011010.3389/fpls.2019.00712458523Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants?Pascal Rey0Maël Taupin-Broggini1Jérémy Couturier2Florence Vignols3Nicolas Rouhier4Plant Protective Proteins Team, CEA, CNRS, BIAM, Aix-Marseille University, Saint-Paul-lez-Durance, FranceBiochimie et Physiologie Moléculaire des Plantes, CNRS/INRA/Université de Montpellier/SupAgro, Montpellier, FranceUniversité de Lorraine, INRA, IAM, Nancy, FranceBiochimie et Physiologie Moléculaire des Plantes, CNRS/INRA/Université de Montpellier/SupAgro, Montpellier, FranceUniversité de Lorraine, INRA, IAM, Nancy, FranceGlutaredoxins (GRXs) have at least three major identified functions. In apoforms, they exhibit oxidoreductase activity controlling notably protein glutathionylation/deglutathionylation. In holoforms, i.e., iron–sulfur (Fe–S) cluster-bridging forms, they act as maturation factors for the biogenesis of Fe–S proteins or as regulators of iron homeostasis contributing directly or indirectly to the sensing of cellular iron status and/or distribution. The latter functions seem intimately connected with the capacity of specific GRXs to form [2Fe–2S] cluster-bridging homodimeric or heterodimeric complexes with BOLA proteins. In yeast species, both proteins modulate the localization and/or activity of transcription factors regulating genes coding for proteins involved in iron uptake and intracellular sequestration in response notably to iron deficiency. Whereas vertebrate GRX and BOLA isoforms may display similar functions, the involved partner proteins are different. We perform here a critical evaluation of the results supporting the implication of both protein families in similar signaling pathways in plants and provide ideas and experimental strategies to delineate further their functions.https://www.frontiersin.org/article/10.3389/fpls.2019.00712/fullBOLAglutaredoxinsiron–sulfur centermaturation factoriron homeostasis |
| spellingShingle | Pascal Rey Maël Taupin-Broggini Jérémy Couturier Florence Vignols Nicolas Rouhier Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants? Frontiers in Plant Science BOLA glutaredoxins iron–sulfur center maturation factor iron homeostasis |
| title | Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants? |
| title_full | Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants? |
| title_fullStr | Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants? |
| title_full_unstemmed | Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants? |
| title_short | Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants? |
| title_sort | is there a role for glutaredoxins and bolas in the perception of the cellular iron status in plants |
| topic | BOLA glutaredoxins iron–sulfur center maturation factor iron homeostasis |
| url | https://www.frontiersin.org/article/10.3389/fpls.2019.00712/full |
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