Outcomes after liver transplantation in Korea: Incidence and risk factors from Korean transplantation registry
Background/Aims To analyze the incidence and risk factors of outcomes after liver transplantation (LT) in the Korean population. Methods This study analyzed data from the liver cohort of Korean Organ Transplantation Registry (KOTRY) who had LT between May 2014 and December 2017. Study measures inclu...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2021-07-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2020-0292.pdf |
| _version_ | 1818865466986201088 |
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| author | Jong Man Kim Deok Gie Kim Jihyun Kim Keunsung Lee Kwang-Woong Lee Je Ho Ryu Bong-Wan Kim Dong Lak Choi Young Kyoung You Dong-Sik Kim Yang Won Nah Koo Jeong Kang Jai Young Cho Geun Hong Hee Chul Yu Ju Ik Moon Dongho Choi Shin Hwang Myoung Soo Kim |
| author_facet | Jong Man Kim Deok Gie Kim Jihyun Kim Keunsung Lee Kwang-Woong Lee Je Ho Ryu Bong-Wan Kim Dong Lak Choi Young Kyoung You Dong-Sik Kim Yang Won Nah Koo Jeong Kang Jai Young Cho Geun Hong Hee Chul Yu Ju Ik Moon Dongho Choi Shin Hwang Myoung Soo Kim |
| author_sort | Jong Man Kim |
| collection | DOAJ |
| description | Background/Aims To analyze the incidence and risk factors of outcomes after liver transplantation (LT) in the Korean population. Methods This study analyzed data from the liver cohort of Korean Organ Transplantation Registry (KOTRY) who had LT between May 2014 and December 2017. Study measures included the incidence of post-LT outcomes in recipients of living donor LT (LDLT) and deceased donor LT (DDLT). Cox multivariate proportional hazards model was used to determine the potential risk factors predicting the outcomes. Results A total of 2,563 adult recipients with LT (LDLT, n=1,956; DDLT, n=607) were included, with mean±standard deviation age of 53.9±8.9 years, and 72.2% were male. The post-LT outcomes observed in each LDLT and DDLT recipients were death (4.0% and 14.7%), graft loss (5.0% and 16.1%), rejection (7.0% and 12.0%), renal failure (2.7% and 13.8%), new onset of diabetes (12.5% and 15.4%), and hepatocellular carcinoma (HCC) recurrence (both 6.7%). In both LDLT and DDLT recipients, the most common post-LT complications were renal dysfunction (33.6% and 51.4%), infection (26.7% and 48.4%), and surgical complication (22.5% and 23.9%). Incidence of these outcomes were generally higher among recipients of DDLT than LDLT. Multivariate analysis indicated recipient age and DDLT as significant risk factors associated with death and graft loss. DDLT and ABO incompatible transplant were prognostic factors for rejection, and HCC beyond Milan criteria at pre-transplant was a strong predictor of HCC recurrence. Conclusions This study is a good indicator of the post-LT prognosis in the Korean population and suggests a significant burden of post-LT complications. |
| first_indexed | 2024-12-19T10:48:00Z |
| format | Article |
| id | doaj.art-8594e849a3f44a3faf0052020c52ba26 |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-19T10:48:00Z |
| publishDate | 2021-07-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-8594e849a3f44a3faf0052020c52ba262022-12-21T20:25:08ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2021-07-0127345146210.3350/cmh.2020.02921602Outcomes after liver transplantation in Korea: Incidence and risk factors from Korean transplantation registryJong Man Kim0Deok Gie Kim1Jihyun Kim2Keunsung Lee3Kwang-Woong Lee4Je Ho Ryu5Bong-Wan Kim6Dong Lak Choi7Young Kyoung You8Dong-Sik Kim9Yang Won Nah10Koo Jeong Kang11Jai Young Cho12Geun Hong13Hee Chul Yu14Ju Ik Moon15Dongho Choi16Shin Hwang17Myoung Soo Kim18 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea Novartis Korea Ltd., Seoul, Korea Novartis Korea Ltd., Seoul, Korea Department of Surgery, Seoul National University College of Medicine, Seoul, Korea Division of Hepato-Biliary-Pancreatic Surgery and liver Transplantation, Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea Department of Liver Transplantation and Hepatobiliary Surgery, Ajou University School of Medicine, Suwon, Korea Department of Surgery, Catholic University of Daegu College of Medicine, Daegu, Korea Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of HBP Surgery & Liver Transplantation, Department of Surgery, Korea University College of Medicine, Seoul, Korea Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea Department of Surgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea Department of Surgery, Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea Department of Surgery, Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea Department of Surgery, Jeonbuk National University Medical School, Jeonju, Korea Department of Surgery, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea Department of Surgery, Hanyang University College of Medicine, Seoul, Korea Department of Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea Department of Surgery, Yonsei University College of Medicine, Seoul, KoreaBackground/Aims To analyze the incidence and risk factors of outcomes after liver transplantation (LT) in the Korean population. Methods This study analyzed data from the liver cohort of Korean Organ Transplantation Registry (KOTRY) who had LT between May 2014 and December 2017. Study measures included the incidence of post-LT outcomes in recipients of living donor LT (LDLT) and deceased donor LT (DDLT). Cox multivariate proportional hazards model was used to determine the potential risk factors predicting the outcomes. Results A total of 2,563 adult recipients with LT (LDLT, n=1,956; DDLT, n=607) were included, with mean±standard deviation age of 53.9±8.9 years, and 72.2% were male. The post-LT outcomes observed in each LDLT and DDLT recipients were death (4.0% and 14.7%), graft loss (5.0% and 16.1%), rejection (7.0% and 12.0%), renal failure (2.7% and 13.8%), new onset of diabetes (12.5% and 15.4%), and hepatocellular carcinoma (HCC) recurrence (both 6.7%). In both LDLT and DDLT recipients, the most common post-LT complications were renal dysfunction (33.6% and 51.4%), infection (26.7% and 48.4%), and surgical complication (22.5% and 23.9%). Incidence of these outcomes were generally higher among recipients of DDLT than LDLT. Multivariate analysis indicated recipient age and DDLT as significant risk factors associated with death and graft loss. DDLT and ABO incompatible transplant were prognostic factors for rejection, and HCC beyond Milan criteria at pre-transplant was a strong predictor of HCC recurrence. Conclusions This study is a good indicator of the post-LT prognosis in the Korean population and suggests a significant burden of post-LT complications.http://e-cmh.org/upload/pdf/cmh-2020-0292.pdfliver transplantationincidencerisk factorsrenal insufficiency |
| spellingShingle | Jong Man Kim Deok Gie Kim Jihyun Kim Keunsung Lee Kwang-Woong Lee Je Ho Ryu Bong-Wan Kim Dong Lak Choi Young Kyoung You Dong-Sik Kim Yang Won Nah Koo Jeong Kang Jai Young Cho Geun Hong Hee Chul Yu Ju Ik Moon Dongho Choi Shin Hwang Myoung Soo Kim Outcomes after liver transplantation in Korea: Incidence and risk factors from Korean transplantation registry Clinical and Molecular Hepatology liver transplantation incidence risk factors renal insufficiency |
| title | Outcomes after liver transplantation in Korea: Incidence and risk factors from Korean transplantation registry |
| title_full | Outcomes after liver transplantation in Korea: Incidence and risk factors from Korean transplantation registry |
| title_fullStr | Outcomes after liver transplantation in Korea: Incidence and risk factors from Korean transplantation registry |
| title_full_unstemmed | Outcomes after liver transplantation in Korea: Incidence and risk factors from Korean transplantation registry |
| title_short | Outcomes after liver transplantation in Korea: Incidence and risk factors from Korean transplantation registry |
| title_sort | outcomes after liver transplantation in korea incidence and risk factors from korean transplantation registry |
| topic | liver transplantation incidence risk factors renal insufficiency |
| url | http://e-cmh.org/upload/pdf/cmh-2020-0292.pdf |
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