A proposal for changing nomenclature from pseudomyxoma peritonei (PMP) to abdomino-peritoneal mucinous carcinoma (APM) based on its long journey and experience from tertiary oncology center in India
Abstract Introduction Pseudomyxoma peritonei (PMP) is a generalized term, usually known as “jelly belly” since 1884. Incidence is very low, 1–3 per million people per year. Because of its indolent nature, it is usually diagnosed at an advanced stage, thereby impacting the quality of life. The 5-year...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02639-6 |
| _version_ | 1828732068550410240 |
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| author | M. D. Ray Manish Kumar Gaur Chandan Kumar S. V. S. Deo |
| author_facet | M. D. Ray Manish Kumar Gaur Chandan Kumar S. V. S. Deo |
| author_sort | M. D. Ray |
| collection | DOAJ |
| description | Abstract Introduction Pseudomyxoma peritonei (PMP) is a generalized term, usually known as “jelly belly” since 1884. Incidence is very low, 1–3 per million people per year. Because of its indolent nature, it is usually diagnosed at an advanced stage, thereby impacting the quality of life. The 5-year survival rate varies from 23 to 86% in world literature. Even 10 years and 20 years of survival have been described. With our experience, we like to propose rename of PMP as abdomino-peritoneal mucinous carcinoma (APM) as we strongly feel the time has come to specify the term and standardize the management strategy. Methodology In the premier institute of India and as a tertiary referral center, we experienced the maximum number of advanced cases of APM. From 2012 to 2021, we analyzed all the APM patients based on a prospectively maintained computerized database in the department of surgical oncology and found the reasons for renaming from this traditional one. Results We included a total of 87 patients who underwent surgical intervention. Thirty-five patients underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), and 52 patients underwent debulking. In CRS-HIPEC patients, CC-0 was achieved in 28 patients (80%), CC-1 in 4 patients (11.4%), and CC-2 in 3 patients (8.6%). Palliative intent HIPEC was done in 3 patients (8.6%). Clavien-Dindo grade III and IV morbidity was observed in 18.8% of patients with 90 days mortality of 5.7%. Conclusion With our long-term experience and advancement of scientific evidence, we like to propose a new name for PMP as APM. We strongly believe this paper will give a clear picture of this rare disease and standard management outlines. |
| first_indexed | 2024-04-12T17:55:39Z |
| format | Article |
| id | doaj.art-8594fe2c92ad4d4d8eef103db3919365 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-12T17:55:39Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-8594fe2c92ad4d4d8eef103db39193652022-12-22T03:22:22ZengBMCWorld Journal of Surgical Oncology1477-78192022-06-0120111010.1186/s12957-022-02639-6A proposal for changing nomenclature from pseudomyxoma peritonei (PMP) to abdomino-peritoneal mucinous carcinoma (APM) based on its long journey and experience from tertiary oncology center in IndiaM. D. Ray0Manish Kumar Gaur1Chandan Kumar2S. V. S. Deo3Department of Surgical Oncology, DR BRA-IRCH, All India Institute of Medical SciencesDepartment of Surgical Oncology, DR BRA-IRCH, All India Institute of Medical SciencesDepartment of Surgical Oncology, DR BRA-IRCH, All India Institute of Medical SciencesDepartment of Surgical Oncology, DR BRA-IRCH, All India Institute of Medical SciencesAbstract Introduction Pseudomyxoma peritonei (PMP) is a generalized term, usually known as “jelly belly” since 1884. Incidence is very low, 1–3 per million people per year. Because of its indolent nature, it is usually diagnosed at an advanced stage, thereby impacting the quality of life. The 5-year survival rate varies from 23 to 86% in world literature. Even 10 years and 20 years of survival have been described. With our experience, we like to propose rename of PMP as abdomino-peritoneal mucinous carcinoma (APM) as we strongly feel the time has come to specify the term and standardize the management strategy. Methodology In the premier institute of India and as a tertiary referral center, we experienced the maximum number of advanced cases of APM. From 2012 to 2021, we analyzed all the APM patients based on a prospectively maintained computerized database in the department of surgical oncology and found the reasons for renaming from this traditional one. Results We included a total of 87 patients who underwent surgical intervention. Thirty-five patients underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), and 52 patients underwent debulking. In CRS-HIPEC patients, CC-0 was achieved in 28 patients (80%), CC-1 in 4 patients (11.4%), and CC-2 in 3 patients (8.6%). Palliative intent HIPEC was done in 3 patients (8.6%). Clavien-Dindo grade III and IV morbidity was observed in 18.8% of patients with 90 days mortality of 5.7%. Conclusion With our long-term experience and advancement of scientific evidence, we like to propose a new name for PMP as APM. We strongly believe this paper will give a clear picture of this rare disease and standard management outlines.https://doi.org/10.1186/s12957-022-02639-6Pseudomyxoma peritonei (PMP)Abdomino-peritoneal mucinous carcinoma (APM)Cytoreductive surgery (CRS)Hyperthermic intraperitoneal chemotherapy (HIPEC)Appendicular neoplasm |
| spellingShingle | M. D. Ray Manish Kumar Gaur Chandan Kumar S. V. S. Deo A proposal for changing nomenclature from pseudomyxoma peritonei (PMP) to abdomino-peritoneal mucinous carcinoma (APM) based on its long journey and experience from tertiary oncology center in India World Journal of Surgical Oncology Pseudomyxoma peritonei (PMP) Abdomino-peritoneal mucinous carcinoma (APM) Cytoreductive surgery (CRS) Hyperthermic intraperitoneal chemotherapy (HIPEC) Appendicular neoplasm |
| title | A proposal for changing nomenclature from pseudomyxoma peritonei (PMP) to abdomino-peritoneal mucinous carcinoma (APM) based on its long journey and experience from tertiary oncology center in India |
| title_full | A proposal for changing nomenclature from pseudomyxoma peritonei (PMP) to abdomino-peritoneal mucinous carcinoma (APM) based on its long journey and experience from tertiary oncology center in India |
| title_fullStr | A proposal for changing nomenclature from pseudomyxoma peritonei (PMP) to abdomino-peritoneal mucinous carcinoma (APM) based on its long journey and experience from tertiary oncology center in India |
| title_full_unstemmed | A proposal for changing nomenclature from pseudomyxoma peritonei (PMP) to abdomino-peritoneal mucinous carcinoma (APM) based on its long journey and experience from tertiary oncology center in India |
| title_short | A proposal for changing nomenclature from pseudomyxoma peritonei (PMP) to abdomino-peritoneal mucinous carcinoma (APM) based on its long journey and experience from tertiary oncology center in India |
| title_sort | proposal for changing nomenclature from pseudomyxoma peritonei pmp to abdomino peritoneal mucinous carcinoma apm based on its long journey and experience from tertiary oncology center in india |
| topic | Pseudomyxoma peritonei (PMP) Abdomino-peritoneal mucinous carcinoma (APM) Cytoreductive surgery (CRS) Hyperthermic intraperitoneal chemotherapy (HIPEC) Appendicular neoplasm |
| url | https://doi.org/10.1186/s12957-022-02639-6 |
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