The Role of Soluble α-klotho Protein in Acromegaly
Soluble α-klotho (sαKl) is an isoform of the α-klotho protein that regulates calcium metabolism but also has anti-aging, anti-apoptotic, and tumor suppressor effects. The assumption that sαKl could inhibit the insulin-like growth factor 1 (IGF-1) signaling pathway has increased the interest of its r...
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| Format: | Article |
| Language: | English |
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Media Med Publicis
2023-03-01
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| Series: | Modern Medicine |
| Subjects: | |
| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2023/03/The-Role-of-Soluble-%CE%B1-klotho-Protein-in-Acromegaly.pdf |
| _version_ | 1797859426765373440 |
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| author | Oana PINZARIU Carmen Emanuela GEORGESCU |
| author_facet | Oana PINZARIU Carmen Emanuela GEORGESCU |
| author_sort | Oana PINZARIU |
| collection | DOAJ |
| description | Soluble α-klotho (sαKl) is an isoform of the α-klotho protein that regulates calcium metabolism but also has anti-aging, anti-apoptotic, and tumor suppressor effects. The assumption that sαKl could inhibit the insulin-like growth factor 1 (IGF-1) signaling pathway has increased the interest of its research in acromegaly - a pathology characterized by an excess of growth hormone (GH) and IGF-1. This review aimed to identify the role of sαKl in acromegaly. Most studies have identified higher concentrations of sαKl in acromegaly versus non-GH pituitary adenomas (PAs) or healthy subjects. Also, the sαKl level was higher in active acromegaly versus controlled or cured disease. Moreover, sαKl positively correlated with GH, IGF-1, and GH-secreting PA size. The increased level of sαKl seems to be due to the autonomous secretion of GH, considering their drastic decrease after transsphenoidal surgery. The data regarding the relationship between sαKl, age, and gender in acromegaly are inconsistent. The latest research noted a correlation between sαKl and various parameters for monitoring the quality of life in acromegaly. In conclusion, sαKl could reflect the disease activity. Furthermore, sαKl would represent an alternative for monitoring acromegalic patients with discrepancies between IGF-1 and GH. |
| first_indexed | 2024-04-09T21:29:17Z |
| format | Article |
| id | doaj.art-859616a76751433c8eab53d51247954f |
| institution | Directory Open Access Journal |
| issn | 1223-0472 2360-2473 |
| language | English |
| last_indexed | 2024-04-09T21:29:17Z |
| publishDate | 2023-03-01 |
| publisher | Media Med Publicis |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj.art-859616a76751433c8eab53d51247954f2023-03-27T10:33:46ZengMedia Med PublicisModern Medicine1223-04722360-24732023-03-013012936https://doi.org/10.31689/rmm.2023.30.1.29The Role of Soluble α-klotho Protein in AcromegalyOana PINZARIU0https://orcid.org/0000-0002-0194-7605Carmen Emanuela GEORGESCU1“Iuliu Hatieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania“Iuliu Hatieganu“ University of Medicine and Pharmacy, Cluj-Napoca, RomaniaSoluble α-klotho (sαKl) is an isoform of the α-klotho protein that regulates calcium metabolism but also has anti-aging, anti-apoptotic, and tumor suppressor effects. The assumption that sαKl could inhibit the insulin-like growth factor 1 (IGF-1) signaling pathway has increased the interest of its research in acromegaly - a pathology characterized by an excess of growth hormone (GH) and IGF-1. This review aimed to identify the role of sαKl in acromegaly. Most studies have identified higher concentrations of sαKl in acromegaly versus non-GH pituitary adenomas (PAs) or healthy subjects. Also, the sαKl level was higher in active acromegaly versus controlled or cured disease. Moreover, sαKl positively correlated with GH, IGF-1, and GH-secreting PA size. The increased level of sαKl seems to be due to the autonomous secretion of GH, considering their drastic decrease after transsphenoidal surgery. The data regarding the relationship between sαKl, age, and gender in acromegaly are inconsistent. The latest research noted a correlation between sαKl and various parameters for monitoring the quality of life in acromegaly. In conclusion, sαKl could reflect the disease activity. Furthermore, sαKl would represent an alternative for monitoring acromegalic patients with discrepancies between IGF-1 and GH.https://medicinamoderna.ro/wp-content/uploads/2023/03/The-Role-of-Soluble-%CE%B1-klotho-Protein-in-Acromegaly.pdfsoluble α-klotho proteinacromegalygrowth hormone-secreting pituitary adenoma |
| spellingShingle | Oana PINZARIU Carmen Emanuela GEORGESCU The Role of Soluble α-klotho Protein in Acromegaly Modern Medicine soluble α-klotho protein acromegaly growth hormone-secreting pituitary adenoma |
| title | The Role of Soluble α-klotho Protein in Acromegaly |
| title_full | The Role of Soluble α-klotho Protein in Acromegaly |
| title_fullStr | The Role of Soluble α-klotho Protein in Acromegaly |
| title_full_unstemmed | The Role of Soluble α-klotho Protein in Acromegaly |
| title_short | The Role of Soluble α-klotho Protein in Acromegaly |
| title_sort | role of soluble α klotho protein in acromegaly |
| topic | soluble α-klotho protein acromegaly growth hormone-secreting pituitary adenoma |
| url | https://medicinamoderna.ro/wp-content/uploads/2023/03/The-Role-of-Soluble-%CE%B1-klotho-Protein-in-Acromegaly.pdf |
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