Increasing Adiposity Is Associated With QTc Interval Prolongation and Increased Ventricular Arrhythmic Risk in the Context of Metabolic Dysfunction: Results From the UK Biobank

Increasing Adiposity Is Associated With QTc Interval Prolongation and Increased Ventricular Arrhythmic Risk in the Context of Metabolic Dysfunction: Results From the UK Biobank

BackgroundSmall-scale studies have linked obesity (Ob) and metabolic ill-health with proarrhythmic repolarisation abnormalities. Whether these are observed at a population scale, modulated by individuals’ genetics, and confer higher risks of ventricular arrhythmias (VA) are not known.Methods and Res...

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Bibliographic Details
Main Authors: Kiran Haresh Kumar Patel, Xinyang Li, Xiao Xu, Lin Sun, Maddalena Ardissino, Prakash P. Punjabi, Sanjay Purkayastha, Nicholas S. Peters, James S. Ware, Fu Siong Ng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
obesity
metabolic syndrome
QTc interval
ventricular arrhythmia
polygenic risk score
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.939156/full

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