Interleukin‐1β Disruption Protects Male Mice From Heart Failure With Preserved Ejection Fraction Pathogenesis

Interleukin‐1β Disruption Protects Male Mice From Heart Failure With Preserved Ejection Fraction Pathogenesis

Background Heart failure with preserved ejection fraction (HFpEF) is a significant unmet need in cardiovascular medicine and remains an untreatable cardiovascular disease. The role and mechanism of interleukin‐1β in HFpEF pathogenesis are poorly understood. Methods and Results C57/Bl6J and interleuk...

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Bibliographic Details
Main Authors: Balaji K. Srinivas, Aya Bourdi, Jacob D. O'Regan, Kumar D. Malavalli, Nour‐Eddine Rhaleb, Souad Belmadani, Khalid Matrougui
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac fibrosis
ER stress
HFpEF
inflammation
interleukin‐1β
vascular endothelial function
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.029668

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