Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia
In 2015, Australia updated premigration screening for tuberculosis (TB) disease in children 2–10 years of age to include testing for infection with Mycobacterium tuberculosis and enable detection of latent TB infection (LTBI). We analyzed TB screening results in children <15 years of age during...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2022-09-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/28/9/21-2426_article |
| _version_ | 1811251297339310080 |
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| author | Ingrid Laemmle-Ruff Stephen M. Graham Bridget Williams Danielle Horyniak Suman S. Majumdar Georgia A. Paxton Lila V. Soares Caplice Margaret E. Hellard James M. Trauer |
| author_facet | Ingrid Laemmle-Ruff Stephen M. Graham Bridget Williams Danielle Horyniak Suman S. Majumdar Georgia A. Paxton Lila V. Soares Caplice Margaret E. Hellard James M. Trauer |
| author_sort | Ingrid Laemmle-Ruff |
| collection | DOAJ |
| description |
In 2015, Australia updated premigration screening for tuberculosis (TB) disease in children 2–10 years of age to include testing for infection with Mycobacterium tuberculosis and enable detection of latent TB infection (LTBI). We analyzed TB screening results in children <15 years of age during November 2015–June 2017. We found 45,060 child applicants were tested with interferon-gamma release assay (IGRA) (57.7% of tests) or tuberculin skin test (TST) (42.3% of tests). A total of 21 cases of TB were diagnosed: 4 without IGRA or TST, 10 with positive IGRA or TST, and 7 with negative results. LTBI was detected in 3.3% (1,473/44,709) of children, for 30 applicants screened per LTBI case detected. LTBI-associated factors included increasing age, TB contact, origin from a higher TB prevalence region, and testing by TST. Detection of TB and LTBI benefit children, but the updated screening program’s effect on TB in Australia is likely to be limited.
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| first_indexed | 2024-04-12T16:18:22Z |
| format | Article |
| id | doaj.art-859897d0102f411681d1f76d259eb07d |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T16:18:22Z |
| publishDate | 2022-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-859897d0102f411681d1f76d259eb07d2022-12-22T03:25:39ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-09-012891833184110.3201/eid2809.212426Detecting Mycobacterium tuberculosis Infection in Children Migrating to AustraliaIngrid Laemmle-RuffStephen M. GrahamBridget WilliamsDanielle HoryniakSuman S. MajumdarGeorgia A. PaxtonLila V. Soares CapliceMargaret E. HellardJames M. Trauer In 2015, Australia updated premigration screening for tuberculosis (TB) disease in children 2–10 years of age to include testing for infection with Mycobacterium tuberculosis and enable detection of latent TB infection (LTBI). We analyzed TB screening results in children <15 years of age during November 2015–June 2017. We found 45,060 child applicants were tested with interferon-gamma release assay (IGRA) (57.7% of tests) or tuberculin skin test (TST) (42.3% of tests). A total of 21 cases of TB were diagnosed: 4 without IGRA or TST, 10 with positive IGRA or TST, and 7 with negative results. LTBI was detected in 3.3% (1,473/44,709) of children, for 30 applicants screened per LTBI case detected. LTBI-associated factors included increasing age, TB contact, origin from a higher TB prevalence region, and testing by TST. Detection of TB and LTBI benefit children, but the updated screening program’s effect on TB in Australia is likely to be limited. https://wwwnc.cdc.gov/eid/article/28/9/21-2426_articletuberculosis and other mycobacterialatent tuberculosis infectionchildrenscreeningmigrationbacteria |
| spellingShingle | Ingrid Laemmle-Ruff Stephen M. Graham Bridget Williams Danielle Horyniak Suman S. Majumdar Georgia A. Paxton Lila V. Soares Caplice Margaret E. Hellard James M. Trauer Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia Emerging Infectious Diseases tuberculosis and other mycobacteria latent tuberculosis infection children screening migration bacteria |
| title | Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia |
| title_full | Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia |
| title_fullStr | Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia |
| title_full_unstemmed | Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia |
| title_short | Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia |
| title_sort | detecting mycobacterium tuberculosis infection in children migrating to australia |
| topic | tuberculosis and other mycobacteria latent tuberculosis infection children screening migration bacteria |
| url | https://wwwnc.cdc.gov/eid/article/28/9/21-2426_article |
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