Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells

Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells

Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity...

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Bibliographic Details
Main Authors: Fang Ke, Zachary L Benet, Mitra P Maz, Jianhua Liu, Alexander L Dent, Joanne Michelle Kahlenberg, Irina L Grigorova
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
follicular regulatory T cells
germinal center b cells
immunologic tolerance
nuclear proteins
Online Access:https://elifesciences.org/articles/83908

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