In Silico Prediction of Drug–Drug Interactions Mediated by Cytochrome P450 Isoforms

In Silico Prediction of Drug–Drug Interactions Mediated by Cytochrome P450 Isoforms

Drug–drug interactions (DDIs) can cause drug toxicities, reduced pharmacological effects, and adverse drug reactions. Studies aiming to determine the possible DDIs for an investigational drug are part of the drug discovery and development process and include an assessment of the DDIs potential media...

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Bibliographic Details
Main Authors: Alexander V. Dmitriev, Anastassia V. Rudik, Dmitry A. Karasev, Pavel V. Pogodin, Alexey A. Lagunin, Dmitry A. Filimonov, Vladimir V. Poroikov
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
drug interaction
DDI
computational prediction
in silico
QSAR
drug metabolism
Online Access:https://www.mdpi.com/1999-4923/13/4/538

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