Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment
Pancreatic cancer is one of the most dangerous types of cancer today, notable for its low survival rate and fibrosis. Deciphering the cellular composition and intercellular interactions in the tumor microenvironment (TME) is a necessary prerequisite to combat pancreatic cancer with precision. Cancer...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152312/full |
| _version_ | 1797866174894047232 |
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| author | Xin Li Jianbo Zhou Xue Wang Chunxi Li Zifan Ma Qiaoling Wan Fu Peng |
| author_facet | Xin Li Jianbo Zhou Xue Wang Chunxi Li Zifan Ma Qiaoling Wan Fu Peng |
| author_sort | Xin Li |
| collection | DOAJ |
| description | Pancreatic cancer is one of the most dangerous types of cancer today, notable for its low survival rate and fibrosis. Deciphering the cellular composition and intercellular interactions in the tumor microenvironment (TME) is a necessary prerequisite to combat pancreatic cancer with precision. Cancer-associated fibroblasts (CAFs), as major producers of extracellular matrix (ECM), play a key role in tumor progression. CAFs display significant heterogeneity and perform different roles in tumor progression. Tumor cells turn CAFs into their slaves by inducing their metabolic dysregulation, exacerbating fibrosis to acquire drug resistance and immune evasion. This article reviews the impact of metabolic reprogramming, effect of obesity and cellular crosstalk of CAFs and tumor cells on fibrosis and describes relevant therapies targeting the metabolic reprogramming. |
| first_indexed | 2024-04-09T23:19:47Z |
| format | Article |
| id | doaj.art-859cdd809e9044788471a913ba43d505 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T23:19:47Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-859cdd809e9044788471a913ba43d5052023-03-22T04:35:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11523121152312Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironmentXin LiJianbo ZhouXue WangChunxi LiZifan MaQiaoling WanFu PengPancreatic cancer is one of the most dangerous types of cancer today, notable for its low survival rate and fibrosis. Deciphering the cellular composition and intercellular interactions in the tumor microenvironment (TME) is a necessary prerequisite to combat pancreatic cancer with precision. Cancer-associated fibroblasts (CAFs), as major producers of extracellular matrix (ECM), play a key role in tumor progression. CAFs display significant heterogeneity and perform different roles in tumor progression. Tumor cells turn CAFs into their slaves by inducing their metabolic dysregulation, exacerbating fibrosis to acquire drug resistance and immune evasion. This article reviews the impact of metabolic reprogramming, effect of obesity and cellular crosstalk of CAFs and tumor cells on fibrosis and describes relevant therapies targeting the metabolic reprogramming.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152312/fullpancreatic cancercancer-associated fibroblastsfibrosismetabolic reprogrammingcrosstalkheterogeneity |
| spellingShingle | Xin Li Jianbo Zhou Xue Wang Chunxi Li Zifan Ma Qiaoling Wan Fu Peng Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment Frontiers in Immunology pancreatic cancer cancer-associated fibroblasts fibrosis metabolic reprogramming crosstalk heterogeneity |
| title | Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment |
| title_full | Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment |
| title_fullStr | Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment |
| title_full_unstemmed | Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment |
| title_short | Pancreatic cancer and fibrosis: Targeting metabolic reprogramming and crosstalk of cancer-associated fibroblasts in the tumor microenvironment |
| title_sort | pancreatic cancer and fibrosis targeting metabolic reprogramming and crosstalk of cancer associated fibroblasts in the tumor microenvironment |
| topic | pancreatic cancer cancer-associated fibroblasts fibrosis metabolic reprogramming crosstalk heterogeneity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152312/full |
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