The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study.
<h4>Objective</h4>The gastrointestinal microbiome in preterm infants exhibits significant influence on optimal outcomes-with dysbiosis shown to substantially increase the risk of the life-threatening necrotizing enterocolitis. Iron is a vital nutrient especially during the perinatal wind...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0297558 |
| _version_ | 1797295152632430592 |
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| author | Matthew VanOrmer Maranda Thompson Melissa Thoene Jean-Jack Riethoven Sathish Kumar Natarajan Corrine Hanson Ann Anderson-Berry |
| author_facet | Matthew VanOrmer Maranda Thompson Melissa Thoene Jean-Jack Riethoven Sathish Kumar Natarajan Corrine Hanson Ann Anderson-Berry |
| author_sort | Matthew VanOrmer |
| collection | DOAJ |
| description | <h4>Objective</h4>The gastrointestinal microbiome in preterm infants exhibits significant influence on optimal outcomes-with dysbiosis shown to substantially increase the risk of the life-threatening necrotizing enterocolitis. Iron is a vital nutrient especially during the perinatal window of rapid hemoglobin production, tissue growth, and foundational neurodevelopment. However, excess colonic iron exhibits potent oxidation capacity and alters the gut microbiome-potentially facilitating the proliferation of pathological bacterial strains. Breastfed preterm infants routinely receive iron supplementation starting 14 days after delivery and are highly vulnerable to morbidities associated with gastrointestinal dysbiosis. Therefore, we set out to determine if routine iron supplementation alters the preterm gut microbiome.<h4>Methods</h4>After IRB approval, we collected stool specimens from 14 infants born <34 weeks gestation in the first, second, and fourth week of life to assess gut microbiome composition via 16S rRNA sequencing.<h4>Results</h4>We observed no significant differences in either phyla or key genera relative abundance between pre- and post-iron timepoints. We observed notable shifts in infant microbiome composition based on season of delivery.<h4>Conclusion</h4>Though no obvious indication of iron-induced dysbiosis was observed in this unique study in the setting of prematurity, further investigation in a larger sample is warranted to fully understand iron's impact on the gastrointestinal milieu. |
| first_indexed | 2024-03-07T21:42:38Z |
| format | Article |
| id | doaj.art-859d326562b44064a5a2a6f0f173bdc1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-07T21:42:38Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-859d326562b44064a5a2a6f0f173bdc12024-02-26T05:31:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01192e029755810.1371/journal.pone.0297558The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study.Matthew VanOrmerMaranda ThompsonMelissa ThoeneJean-Jack RiethovenSathish Kumar NatarajanCorrine HansonAnn Anderson-Berry<h4>Objective</h4>The gastrointestinal microbiome in preterm infants exhibits significant influence on optimal outcomes-with dysbiosis shown to substantially increase the risk of the life-threatening necrotizing enterocolitis. Iron is a vital nutrient especially during the perinatal window of rapid hemoglobin production, tissue growth, and foundational neurodevelopment. However, excess colonic iron exhibits potent oxidation capacity and alters the gut microbiome-potentially facilitating the proliferation of pathological bacterial strains. Breastfed preterm infants routinely receive iron supplementation starting 14 days after delivery and are highly vulnerable to morbidities associated with gastrointestinal dysbiosis. Therefore, we set out to determine if routine iron supplementation alters the preterm gut microbiome.<h4>Methods</h4>After IRB approval, we collected stool specimens from 14 infants born <34 weeks gestation in the first, second, and fourth week of life to assess gut microbiome composition via 16S rRNA sequencing.<h4>Results</h4>We observed no significant differences in either phyla or key genera relative abundance between pre- and post-iron timepoints. We observed notable shifts in infant microbiome composition based on season of delivery.<h4>Conclusion</h4>Though no obvious indication of iron-induced dysbiosis was observed in this unique study in the setting of prematurity, further investigation in a larger sample is warranted to fully understand iron's impact on the gastrointestinal milieu.https://doi.org/10.1371/journal.pone.0297558 |
| spellingShingle | Matthew VanOrmer Maranda Thompson Melissa Thoene Jean-Jack Riethoven Sathish Kumar Natarajan Corrine Hanson Ann Anderson-Berry The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study. PLoS ONE |
| title | The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study. |
| title_full | The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study. |
| title_fullStr | The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study. |
| title_full_unstemmed | The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study. |
| title_short | The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study. |
| title_sort | impact of iron supplementation on the preterm neonatal gut microbiome a pilot study |
| url | https://doi.org/10.1371/journal.pone.0297558 |
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