Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl
Nationally distributed medications from compounding pharmacies, which typically adhere to less stringent quality-control standards than pharmaceutical manufacturers, can lead to multistate outbreaks. We investigated a cluster of 6 patients in a Maryland hospital who had Sphingomonas paucimobilis blo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2009-01-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/15/1/08-1054_article |
| _version_ | 1818446536497954816 |
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| author | Lisa L. Maragakis Romanee Chaiwarith Arjun Srinivasan Francesca J. Torriani Edina Avdic Andrew Lee Tracy R. Ross Karen C. Carroll Trish M. Perl |
| author_facet | Lisa L. Maragakis Romanee Chaiwarith Arjun Srinivasan Francesca J. Torriani Edina Avdic Andrew Lee Tracy R. Ross Karen C. Carroll Trish M. Perl |
| author_sort | Lisa L. Maragakis |
| collection | DOAJ |
| description | Nationally distributed medications from compounding pharmacies, which typically adhere to less stringent quality-control standards than pharmaceutical manufacturers, can lead to multistate outbreaks. We investigated a cluster of 6 patients in a Maryland hospital who had Sphingomonas paucimobilis bloodstream infections in November 2007. Of the 6 case-patients, 5 (83%) had received intravenous fentanyl within 48 hours before bacteremia developed. Cultures of unopened samples of fentanyl grew S. paucimobilis; the pulsed-field gel electrophoresis pattern was indistinguishable from that of the isolates of 5 case-patients. The contaminated fentanyl lot had been prepared at a compounding pharmacy and distributed to 4 states. Subsequently, in California, S. paucimobilis bacteremia was diagnosed for 2 patients who had received intravenous fentanyl from the same compounding pharmacy. These pharmacies should adopt more stringent quality-control measures, including prerelease product testing, when compounding and distributing large quantities of sterile preparations. |
| first_indexed | 2024-12-14T19:49:17Z |
| format | Article |
| id | doaj.art-859daf5670dc4df8bc3f4030cb242a42 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-14T19:49:17Z |
| publishDate | 2009-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-859daf5670dc4df8bc3f4030cb242a422022-12-21T22:49:27ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592009-01-01151121810.3201/eid1501.081054Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous FentanylLisa L. MaragakisRomanee ChaiwarithArjun SrinivasanFrancesca J. TorrianiEdina AvdicAndrew LeeTracy R. RossKaren C. CarrollTrish M. PerlNationally distributed medications from compounding pharmacies, which typically adhere to less stringent quality-control standards than pharmaceutical manufacturers, can lead to multistate outbreaks. We investigated a cluster of 6 patients in a Maryland hospital who had Sphingomonas paucimobilis bloodstream infections in November 2007. Of the 6 case-patients, 5 (83%) had received intravenous fentanyl within 48 hours before bacteremia developed. Cultures of unopened samples of fentanyl grew S. paucimobilis; the pulsed-field gel electrophoresis pattern was indistinguishable from that of the isolates of 5 case-patients. The contaminated fentanyl lot had been prepared at a compounding pharmacy and distributed to 4 states. Subsequently, in California, S. paucimobilis bacteremia was diagnosed for 2 patients who had received intravenous fentanyl from the same compounding pharmacy. These pharmacies should adopt more stringent quality-control measures, including prerelease product testing, when compounding and distributing large quantities of sterile preparations.https://wwwnc.cdc.gov/eid/article/15/1/08-1054_articleSphingomonasoutbreakhealthcare-associated infectionscompounding pharmacyresearchUnited States |
| spellingShingle | Lisa L. Maragakis Romanee Chaiwarith Arjun Srinivasan Francesca J. Torriani Edina Avdic Andrew Lee Tracy R. Ross Karen C. Carroll Trish M. Perl Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl Emerging Infectious Diseases Sphingomonas outbreak healthcare-associated infections compounding pharmacy research United States |
| title | Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl |
| title_full | Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl |
| title_fullStr | Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl |
| title_full_unstemmed | Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl |
| title_short | Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl |
| title_sort | sphingomonas paucimobilis bloodstream infections associated with contaminated intravenous fentanyl |
| topic | Sphingomonas outbreak healthcare-associated infections compounding pharmacy research United States |
| url | https://wwwnc.cdc.gov/eid/article/15/1/08-1054_article |
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