Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses
In the 21st Century, emergence and re-emergence of infectious diseases is significant and has an increasing importance in global concern of public health. Based on the COVID-19 pandemic and recently reported epidemics, most human pathogens originate in zoonosis. Many of such pathogens are related to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Drug Discovery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fddsv.2023.1176768/full |
| _version_ | 1797814352796975104 |
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| author | Danilo Rosa-Nunes Danilo B. M. Lucchi Robert Andreata-Santos Luiz Mario R. Janini Carla Torres Braconi |
| author_facet | Danilo Rosa-Nunes Danilo B. M. Lucchi Robert Andreata-Santos Luiz Mario R. Janini Carla Torres Braconi |
| author_sort | Danilo Rosa-Nunes |
| collection | DOAJ |
| description | In the 21st Century, emergence and re-emergence of infectious diseases is significant and has an increasing importance in global concern of public health. Based on the COVID-19 pandemic and recently reported epidemics, most human pathogens originate in zoonosis. Many of such pathogens are related to viruses that have RNA genomes, which can be presented structurally as a single-strand or double-strand. During the last two decades, a timeline of major RNA viruses emergencies can be exemplified, such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) in 2003, influenza A virus (H1N1) pdm09 in 2009, Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, Ebola virus (EBOV) in 2013–2016, Zika virus (ZIKV) in 2015 and the SARS-CoV-2 pdm19 in 2019. Even so, prophylactic or therapeutic drugs are unavailable for many RNA viruses circulating. Nonetheless, the COVID-19 pandemic brought considerable scientific advances in accelerating progress regarding prophylaxis, antiviral and drug development, and novel treatments. Regarding RNA virus diseases for humans, arboviruses play an essential and neglected role, constantly reemerging and affecting almost half of the human population, for which no drug has been licensed. Here we review the consolidated RNA viruses’ emergence and re-emergence in the 21st Century through available data. Then, we explored valuable lessons gained during the SARS-CoV-2 pandemic and focused on potential epidemiologic updates, prophylaxis, available treatments, and viral drug inhibitors. Finally, we explore arbovirus’s significance and the ongoing development of effective vaccines, antiviral drugs, and novel therapeutic approaches as strategies to control these neglected tropical diseases (NTD). |
| first_indexed | 2024-03-13T08:06:26Z |
| format | Article |
| id | doaj.art-859f8928fda14b6a9e508e4dabf81c69 |
| institution | Directory Open Access Journal |
| issn | 2674-0338 |
| language | English |
| last_indexed | 2024-03-13T08:06:26Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Drug Discovery |
| spelling | doaj.art-859f8928fda14b6a9e508e4dabf81c692023-06-01T05:00:25ZengFrontiers Media S.A.Frontiers in Drug Discovery2674-03382023-06-01310.3389/fddsv.2023.11767681176768Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arbovirusesDanilo Rosa-Nunes0Danilo B. M. Lucchi1Robert Andreata-Santos2Luiz Mario R. Janini3Carla Torres Braconi4Laboratory of Arbovirus Research, Department of Microbiology, Immunology and Parasitology of the Federal University of São Paulo (UNIFESP), São Paulo, BrazilLaboratory of Arbovirus Research, Department of Microbiology, Immunology and Parasitology of the Federal University of São Paulo (UNIFESP), São Paulo, BrazilRetrovirology Laboratory, Department of Microbiology of Immunology and Parasitology of the Federal University of São Paulo (UNIFESP), São Paulo, BrazilRetrovirology Laboratory, Department of Microbiology of Immunology and Parasitology of the Federal University of São Paulo (UNIFESP), São Paulo, BrazilLaboratory of Arbovirus Research, Department of Microbiology, Immunology and Parasitology of the Federal University of São Paulo (UNIFESP), São Paulo, BrazilIn the 21st Century, emergence and re-emergence of infectious diseases is significant and has an increasing importance in global concern of public health. Based on the COVID-19 pandemic and recently reported epidemics, most human pathogens originate in zoonosis. Many of such pathogens are related to viruses that have RNA genomes, which can be presented structurally as a single-strand or double-strand. During the last two decades, a timeline of major RNA viruses emergencies can be exemplified, such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) in 2003, influenza A virus (H1N1) pdm09 in 2009, Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, Ebola virus (EBOV) in 2013–2016, Zika virus (ZIKV) in 2015 and the SARS-CoV-2 pdm19 in 2019. Even so, prophylactic or therapeutic drugs are unavailable for many RNA viruses circulating. Nonetheless, the COVID-19 pandemic brought considerable scientific advances in accelerating progress regarding prophylaxis, antiviral and drug development, and novel treatments. Regarding RNA virus diseases for humans, arboviruses play an essential and neglected role, constantly reemerging and affecting almost half of the human population, for which no drug has been licensed. Here we review the consolidated RNA viruses’ emergence and re-emergence in the 21st Century through available data. Then, we explored valuable lessons gained during the SARS-CoV-2 pandemic and focused on potential epidemiologic updates, prophylaxis, available treatments, and viral drug inhibitors. Finally, we explore arbovirus’s significance and the ongoing development of effective vaccines, antiviral drugs, and novel therapeutic approaches as strategies to control these neglected tropical diseases (NTD).https://www.frontiersin.org/articles/10.3389/fddsv.2023.1176768/fullzoonotic virusarbovirosesemerging and reemerging virusesantiviral drugsneglected tropical diseases (NTD) |
| spellingShingle | Danilo Rosa-Nunes Danilo B. M. Lucchi Robert Andreata-Santos Luiz Mario R. Janini Carla Torres Braconi Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses Frontiers in Drug Discovery zoonotic virus arboviroses emerging and reemerging viruses antiviral drugs neglected tropical diseases (NTD) |
| title | Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses |
| title_full | Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses |
| title_fullStr | Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses |
| title_full_unstemmed | Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses |
| title_short | Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses |
| title_sort | lessons that can be learned from the sars cov 2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses |
| topic | zoonotic virus arboviroses emerging and reemerging viruses antiviral drugs neglected tropical diseases (NTD) |
| url | https://www.frontiersin.org/articles/10.3389/fddsv.2023.1176768/full |
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