Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia
So far, neuroendocrine studies conducted in schizophrenic patients have yielded conflicting results. Many of these discrepancies may be explained by the diversity of factors that influence the hormonal levels (at baseline and in response to pharmacological stimuli), the heterogeneity of the populati...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Healthcare |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9032/11/10/1487 |
| _version_ | 1797599955975667712 |
|---|---|
| author | Fabrice Duval |
| author_facet | Fabrice Duval |
| author_sort | Fabrice Duval |
| collection | DOAJ |
| description | So far, neuroendocrine studies conducted in schizophrenic patients have yielded conflicting results. Many of these discrepancies may be explained by the diversity of factors that influence the hormonal levels (at baseline and in response to pharmacological stimuli), the heterogeneity of the populations studied, the absence of standardization of test challenges and the confounding and long-lasting effects of previous treatments. Numerous studies have used apomorphine (APO) in the evaluation of dopaminergic (DA) function in schizophrenic patients. APO, a direct acting DA receptor agonist, decreases prolactin (PRL) and stimulates growth hormone (GH), adrenocorticotropic hormone (ACTH) and cortisol secretion. Therefore, the magnitude of hormonal responses to APO is an indirect assessment of the functionality of DA receptors at the hypothalamic–pituitary level. This review provides an update on the applications of the APO test in schizophrenia in clinical, pathophysiological and therapeutic fields. |
| first_indexed | 2024-03-11T03:41:40Z |
| format | Article |
| id | doaj.art-859fab4d604d48eca843cff686fc5cb3 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T03:41:40Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-859fab4d604d48eca843cff686fc5cb32023-11-18T01:33:04ZengMDPI AGHealthcare2227-90322023-05-011110148710.3390/healthcare11101487Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in SchizophreniaFabrice Duval0Pôle 8/9-APF2R, Centre Hospitalier, 68250 Rouffach, FranceSo far, neuroendocrine studies conducted in schizophrenic patients have yielded conflicting results. Many of these discrepancies may be explained by the diversity of factors that influence the hormonal levels (at baseline and in response to pharmacological stimuli), the heterogeneity of the populations studied, the absence of standardization of test challenges and the confounding and long-lasting effects of previous treatments. Numerous studies have used apomorphine (APO) in the evaluation of dopaminergic (DA) function in schizophrenic patients. APO, a direct acting DA receptor agonist, decreases prolactin (PRL) and stimulates growth hormone (GH), adrenocorticotropic hormone (ACTH) and cortisol secretion. Therefore, the magnitude of hormonal responses to APO is an indirect assessment of the functionality of DA receptors at the hypothalamic–pituitary level. This review provides an update on the applications of the APO test in schizophrenia in clinical, pathophysiological and therapeutic fields.https://www.mdpi.com/2227-9032/11/10/1487schizophreniaapomorphine testprolactingrowth hormoneadrenocorticotropic hormonecortisol |
| spellingShingle | Fabrice Duval Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia Healthcare schizophrenia apomorphine test prolactin growth hormone adrenocorticotropic hormone cortisol |
| title | Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia |
| title_full | Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia |
| title_fullStr | Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia |
| title_full_unstemmed | Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia |
| title_short | Systematic Review of the Apomorphine Challenge Test in the Assessment of Dopaminergic Activity in Schizophrenia |
| title_sort | systematic review of the apomorphine challenge test in the assessment of dopaminergic activity in schizophrenia |
| topic | schizophrenia apomorphine test prolactin growth hormone adrenocorticotropic hormone cortisol |
| url | https://www.mdpi.com/2227-9032/11/10/1487 |
| work_keys_str_mv | AT fabriceduval systematicreviewoftheapomorphinechallengetestintheassessmentofdopaminergicactivityinschizophrenia |