First case series reported in Colombia of primary and secondary cold agglutinin disease. Experience of a reference center in Medellín between 2010 and 2017
Introduction: Cold agglutinin disease (CAD) is a primary hematologic disorder or can be secondary to another disease. CAD is characterized by autoim-mune hemolytic anemia associated with IgM type antibodies, at low temperatures. Clinically CAD is associated with cryoparesth...
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| Format: | Article |
| Language: | Spanish |
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Universidad de Antioquia
2020-04-01
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| Series: | Iatreia |
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| Online Access: | https://revistas.udea.edu.co/index.php/iatreia/article/view/336943/20802235 |
| _version_ | 1828450711714660352 |
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| author | Quintero, Catalina |
| author_facet | Quintero, Catalina |
| author_sort | Quintero, Catalina |
| collection | DOAJ |
| description | Introduction: Cold agglutinin disease (CAD) is a primary hematologic disorder or can be secondary to another disease. CAD is characterized by autoim-mune hemolytic anemia associated with IgM type antibodies, at low temperatures. Clinically CAD is associated with cryoparesthesia and acrocyanosis induced by cold and fever, or it can be asymptomatic and can be detected by abnormalities on cell blood counts.
Objective: To describe the clinical and laboratory data and the etiology of CAD. Comparison between this case series and those described in the literature.
Materials and Methods: Retrospectively, we analy-zed clinical data of patients from Hospital Universi-tario San Vicente Fundación with positive results for cold agglutinin assays made in the hematology lab from Universidad de Antioquia. We consider patients with titers ≥ 1:64 or Coombs test positive for cold an-tibodies.
Results: We describe clinical and laboratory findings included crioagglutinin titers of 23 cases with CAD: 6 of them with primary CAD, 4 with non-Hodgkin Lym-phoma (NHL), 8 patients with CAD associated with infectious and autoimmune disease and 5 with CAD miscellaneous diseases.
Disscusion and Conclusions: This is the first CAD case series described in Colombia. Age and gender were like others case series. Most of patients presented with hemolityc anemia and cold related symptoms. The hemoglobin/ hematocrit ratio was 1:2. Secondary causes were vasculitis, lupus and malaria. Primary CAD were related to NHL, specifically limphoplasmo-cytic Most of the treatments of primary CAD included rituximab. |
| first_indexed | 2024-12-10T23:26:24Z |
| format | Article |
| id | doaj.art-85a2c1062707423485dc8f30770e90aa |
| institution | Directory Open Access Journal |
| issn | 0121-0793 2011-7965 |
| language | Spanish |
| last_indexed | 2024-12-10T23:26:24Z |
| publishDate | 2020-04-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Iatreia |
| spelling | doaj.art-85a2c1062707423485dc8f30770e90aa2022-12-22T01:29:34ZspaUniversidad de AntioquiaIatreia0121-07932011-79652020-04-0133212313210.17533/udea.iatreia.40First case series reported in Colombia of primary and secondary cold agglutinin disease. Experience of a reference center in Medellín between 2010 and 2017Quintero, Catalina 0https://orcid.org/0000-0003-1721-7567Universidad de AntioquiaIntroduction: Cold agglutinin disease (CAD) is a primary hematologic disorder or can be secondary to another disease. CAD is characterized by autoim-mune hemolytic anemia associated with IgM type antibodies, at low temperatures. Clinically CAD is associated with cryoparesthesia and acrocyanosis induced by cold and fever, or it can be asymptomatic and can be detected by abnormalities on cell blood counts. Objective: To describe the clinical and laboratory data and the etiology of CAD. Comparison between this case series and those described in the literature. Materials and Methods: Retrospectively, we analy-zed clinical data of patients from Hospital Universi-tario San Vicente Fundación with positive results for cold agglutinin assays made in the hematology lab from Universidad de Antioquia. We consider patients with titers ≥ 1:64 or Coombs test positive for cold an-tibodies. Results: We describe clinical and laboratory findings included crioagglutinin titers of 23 cases with CAD: 6 of them with primary CAD, 4 with non-Hodgkin Lym-phoma (NHL), 8 patients with CAD associated with infectious and autoimmune disease and 5 with CAD miscellaneous diseases. Disscusion and Conclusions: This is the first CAD case series described in Colombia. Age and gender were like others case series. Most of patients presented with hemolityc anemia and cold related symptoms. The hemoglobin/ hematocrit ratio was 1:2. Secondary causes were vasculitis, lupus and malaria. Primary CAD were related to NHL, specifically limphoplasmo-cytic Most of the treatments of primary CAD included rituximab.https://revistas.udea.edu.co/index.php/iatreia/article/view/336943/20802235autoimmune hemolytic anemiacold agglutinin diseaselymphomahematologic neoplasmsrituximab |
| spellingShingle | Quintero, Catalina First case series reported in Colombia of primary and secondary cold agglutinin disease. Experience of a reference center in Medellín between 2010 and 2017 Iatreia autoimmune hemolytic anemia cold agglutinin disease lymphoma hematologic neoplasms rituximab |
| title | First case series reported in Colombia of primary and secondary cold agglutinin disease. Experience of a reference center in Medellín between 2010 and 2017 |
| title_full | First case series reported in Colombia of primary and secondary cold agglutinin disease. Experience of a reference center in Medellín between 2010 and 2017 |
| title_fullStr | First case series reported in Colombia of primary and secondary cold agglutinin disease. Experience of a reference center in Medellín between 2010 and 2017 |
| title_full_unstemmed | First case series reported in Colombia of primary and secondary cold agglutinin disease. Experience of a reference center in Medellín between 2010 and 2017 |
| title_short | First case series reported in Colombia of primary and secondary cold agglutinin disease. Experience of a reference center in Medellín between 2010 and 2017 |
| title_sort | first case series reported in colombia of primary and secondary cold agglutinin disease experience of a reference center in medellin between 2010 and 2017 |
| topic | autoimmune hemolytic anemia cold agglutinin disease lymphoma hematologic neoplasms rituximab |
| url | https://revistas.udea.edu.co/index.php/iatreia/article/view/336943/20802235 |
| work_keys_str_mv | AT quinterocatalina firstcaseseriesreportedincolombiaofprimaryandsecondarycoldagglutinindiseaseexperienceofareferencecenterinmedellinbetween2010and2017 |