RNA-binding proteins regulating the CD44 alternative splicing
Alternative splicing is often deregulated in cancer, and cancer-specific isoform switches are part of the oncogenic transformation of cells. Accumulating evidence indicates that isoforms of the multifunctional cell-surface glycoprotein CD44 play different roles in cancer cells as compared to normal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1326148/full |
| _version_ | 1797435121007067136 |
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| author | Diana Maltseva Alexander Tonevitsky Alexander Tonevitsky |
| author_facet | Diana Maltseva Alexander Tonevitsky Alexander Tonevitsky |
| author_sort | Diana Maltseva |
| collection | DOAJ |
| description | Alternative splicing is often deregulated in cancer, and cancer-specific isoform switches are part of the oncogenic transformation of cells. Accumulating evidence indicates that isoforms of the multifunctional cell-surface glycoprotein CD44 play different roles in cancer cells as compared to normal cells. In particular, the shift of CD44 isoforms is required for epithelial to mesenchymal transition (EMT) and is crucial for the maintenance of pluripotency in normal human cells and the acquisition of cancer stem cells phenotype for malignant cells. The growing and seemingly promising use of splicing inhibitors for treating cancer and other pathologies gives hope for the prospect of using such an approach to regulate CD44 alternative splicing. This review integrates current knowledge about regulating CD44 alternative splicing by RNA-binding proteins. |
| first_indexed | 2024-03-09T10:42:40Z |
| format | Article |
| id | doaj.art-85a52239a53d492ab82b26a15d7104fb |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-09T10:42:40Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-85a52239a53d492ab82b26a15d7104fb2023-12-01T12:28:33ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-12-011010.3389/fmolb.2023.13261481326148RNA-binding proteins regulating the CD44 alternative splicingDiana Maltseva0Alexander Tonevitsky1Alexander Tonevitsky2Faculty of Biology and Biotechnology, HSE University, Moscow, RussiaFaculty of Biology and Biotechnology, HSE University, Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, RussiaAlternative splicing is often deregulated in cancer, and cancer-specific isoform switches are part of the oncogenic transformation of cells. Accumulating evidence indicates that isoforms of the multifunctional cell-surface glycoprotein CD44 play different roles in cancer cells as compared to normal cells. In particular, the shift of CD44 isoforms is required for epithelial to mesenchymal transition (EMT) and is crucial for the maintenance of pluripotency in normal human cells and the acquisition of cancer stem cells phenotype for malignant cells. The growing and seemingly promising use of splicing inhibitors for treating cancer and other pathologies gives hope for the prospect of using such an approach to regulate CD44 alternative splicing. This review integrates current knowledge about regulating CD44 alternative splicing by RNA-binding proteins.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1326148/fullCD44 alternative splicing regulationCD44 isoformRNA-binding proteincancerESRP1 |
| spellingShingle | Diana Maltseva Alexander Tonevitsky Alexander Tonevitsky RNA-binding proteins regulating the CD44 alternative splicing Frontiers in Molecular Biosciences CD44 alternative splicing regulation CD44 isoform RNA-binding protein cancer ESRP1 |
| title | RNA-binding proteins regulating the CD44 alternative splicing |
| title_full | RNA-binding proteins regulating the CD44 alternative splicing |
| title_fullStr | RNA-binding proteins regulating the CD44 alternative splicing |
| title_full_unstemmed | RNA-binding proteins regulating the CD44 alternative splicing |
| title_short | RNA-binding proteins regulating the CD44 alternative splicing |
| title_sort | rna binding proteins regulating the cd44 alternative splicing |
| topic | CD44 alternative splicing regulation CD44 isoform RNA-binding protein cancer ESRP1 |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1326148/full |
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