Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons

Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons

Abstract G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins and are important drug targets. The discovery of drugs targeting these receptors and their G protein signaling properties are based on assays mainly performed with modified receptors expressed in heterolo...

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Bibliographic Details
Main Authors: Chanjuan Xu, Yiwei Zhou, Yuxuan Liu, Li Lin, Peng Liu, Xiaomei Wang, Zhengyuan Xu, Jean-Philippe Pin, Philippe Rondard, Jianfeng Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46177-z

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