Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans
The anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining them from a widely distributed and renewable source, makes them attractive novel bioa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/3/808 |
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| author | Noelia Flórez-Fernández Carlos Vaamonde-García Maria Dolores Torres Manuela Buján Alexandra Muíños Antonio Muiños María J. Lamas-Vázquez Rosa Meijide-Faílde Francisco J. Blanco Herminia Domínguez |
| author_facet | Noelia Flórez-Fernández Carlos Vaamonde-García Maria Dolores Torres Manuela Buján Alexandra Muíños Antonio Muiños María J. Lamas-Vázquez Rosa Meijide-Faílde Francisco J. Blanco Herminia Domínguez |
| author_sort | Noelia Flórez-Fernández |
| collection | DOAJ |
| description | The anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining them from a widely distributed and renewable source, makes them attractive novel bioactives. However, fucoidans’ heterogeneity and variability in composition, structure, and properties depending on seaweed species, biotic and abiotic factors and processing conditions, especially during extraction and purification stages, make it difficult for standardization. A review of the available technologies, including those based on intensification strategies, and their influence on fucoidan composition, structure, and anti-inflammatory potential of crude extracts and fractions is presented. |
| first_indexed | 2024-03-11T06:02:20Z |
| format | Article |
| id | doaj.art-85ab81e4eeba4364a9914c97db519040 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T06:02:20Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-85ab81e4eeba4364a9914c97db5190402023-11-17T13:14:40ZengMDPI AGPharmaceutics1999-49232023-03-0115380810.3390/pharmaceutics15030808Relevance of the Extraction Stage on the Anti-Inflammatory Action of FucoidansNoelia Flórez-Fernández0Carlos Vaamonde-García1Maria Dolores Torres2Manuela Buján3Alexandra Muíños4Antonio Muiños5María J. Lamas-Vázquez6Rosa Meijide-Faílde7Francisco J. Blanco8Herminia Domínguez9CINBIO, Departamento de Ingeniería Química, Campus Ourense, Universidade de Vigo, 32004 Ourense, SpainGrupo de Investigación de Reumatología y Salud (GIR-S), Departamento de Biología, Facultad de Ciencias, CICA-Centro Interdisciplinar de Química y Biología, INIBIC-Sergas, Universidade da Coruña, Campus da Zapateira, 15011 A Coruña, SpainCINBIO, Departamento de Ingeniería Química, Campus Ourense, Universidade de Vigo, 32004 Ourense, SpainPortomuíños, Polígono Industrial, Rúa Acebedo, Parcela 14, Cerceda, 15185 A Coruña, SpainPortomuíños, Polígono Industrial, Rúa Acebedo, Parcela 14, Cerceda, 15185 A Coruña, SpainPortomuíños, Polígono Industrial, Rúa Acebedo, Parcela 14, Cerceda, 15185 A Coruña, SpainGrupo de Investigación de Reumatología y Salud (GIR-S), Departamento de Biología, Facultad de Ciencias, CICA-Centro Interdisciplinar de Química y Biología, INIBIC-Sergas, Universidade da Coruña, Campus da Zapateira, 15011 A Coruña, SpainGrupo de Terapia Celular y Medicina Regenerativa, Universidade da Coruña, CICA-Centro Interdisciplinar de Química y Biología, Complexo Hospitalario Universitario A Coruña, Campus Oza, 15006 A Coruña, SpainGrupo de Investigación de Reumatología y Salud (GIR-S), Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, CICA-Centro Interdisciplinar de Química y Biología, INIBIC-Sergas, Universidade da Coruña, Campus de Oza, 15006 A Coruña, SpainCINBIO, Departamento de Ingeniería Química, Campus Ourense, Universidade de Vigo, 32004 Ourense, SpainThe anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining them from a widely distributed and renewable source, makes them attractive novel bioactives. However, fucoidans’ heterogeneity and variability in composition, structure, and properties depending on seaweed species, biotic and abiotic factors and processing conditions, especially during extraction and purification stages, make it difficult for standardization. A review of the available technologies, including those based on intensification strategies, and their influence on fucoidan composition, structure, and anti-inflammatory potential of crude extracts and fractions is presented.https://www.mdpi.com/1999-4923/15/3/808brown seaweedsulphated polysaccharidesextractioninflammation |
| spellingShingle | Noelia Flórez-Fernández Carlos Vaamonde-García Maria Dolores Torres Manuela Buján Alexandra Muíños Antonio Muiños María J. Lamas-Vázquez Rosa Meijide-Faílde Francisco J. Blanco Herminia Domínguez Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans Pharmaceutics brown seaweed sulphated polysaccharides extraction inflammation |
| title | Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans |
| title_full | Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans |
| title_fullStr | Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans |
| title_full_unstemmed | Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans |
| title_short | Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans |
| title_sort | relevance of the extraction stage on the anti inflammatory action of fucoidans |
| topic | brown seaweed sulphated polysaccharides extraction inflammation |
| url | https://www.mdpi.com/1999-4923/15/3/808 |
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