New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition
The overuse of antibiotics and the emergence of multiple-antibiotic-resistant pathogens are becoming a serious threat to health security and the economy. Reducing antimicrobial resistance requires replacing antibiotic consumption with more biocontrol strategies to improve the immunity of animals and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/15/9/570 |
| _version_ | 1797576550388858880 |
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| author | Hua Zhang Zhen Zhang Jing Li Guangyong Qin |
| author_facet | Hua Zhang Zhen Zhang Jing Li Guangyong Qin |
| author_sort | Hua Zhang |
| collection | DOAJ |
| description | The overuse of antibiotics and the emergence of multiple-antibiotic-resistant pathogens are becoming a serious threat to health security and the economy. Reducing antimicrobial resistance requires replacing antibiotic consumption with more biocontrol strategies to improve the immunity of animals and humans. Probiotics and medicinal plants have been used as alternative treatments or preventative therapies for a variety of diseases caused by bacterial infections. Therefore, we reviewed some of the anti-virulence and bacterial toxin-inhibiting strategies that are currently being developed; this review covers strategies focused on quenching pathogen quorum sensing (QS) systems, the disruption of biofilm formation and bacterial toxin neutralization. It highlights the probable mechanism of action for probiotics and medicinal plants. Although further research is needed before a definitive statement can be made on the efficacy of any of these interventions, the current literature offers new hope and a new tool in the arsenal in the fight against bacterial virulence factors and bacterial toxins. |
| first_indexed | 2024-03-10T21:53:44Z |
| format | Article |
| id | doaj.art-85ae6ab725f649bea0eaa517d02740ab |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T21:53:44Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-85ae6ab725f649bea0eaa517d02740ab2023-11-19T13:16:11ZengMDPI AGToxins2072-66512023-09-0115957010.3390/toxins15090570New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm InhibitionHua Zhang0Zhen Zhang1Jing Li2Guangyong Qin3Henan Key Laboratory of Ion Beam Bio-Engineering, College of Physics, Zhengzhou University, Zhengzhou 450000, ChinaSchool of Food and Biological Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, ChinaSchool of Food and Biological Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, ChinaSchool of Agricultural Sciences, Zhengzhou University, Zhengzhou 450000, ChinaThe overuse of antibiotics and the emergence of multiple-antibiotic-resistant pathogens are becoming a serious threat to health security and the economy. Reducing antimicrobial resistance requires replacing antibiotic consumption with more biocontrol strategies to improve the immunity of animals and humans. Probiotics and medicinal plants have been used as alternative treatments or preventative therapies for a variety of diseases caused by bacterial infections. Therefore, we reviewed some of the anti-virulence and bacterial toxin-inhibiting strategies that are currently being developed; this review covers strategies focused on quenching pathogen quorum sensing (QS) systems, the disruption of biofilm formation and bacterial toxin neutralization. It highlights the probable mechanism of action for probiotics and medicinal plants. Although further research is needed before a definitive statement can be made on the efficacy of any of these interventions, the current literature offers new hope and a new tool in the arsenal in the fight against bacterial virulence factors and bacterial toxins.https://www.mdpi.com/2072-6651/15/9/570biocontrolbacterial toxinsvirulenceprobioticsmedicinal plants |
| spellingShingle | Hua Zhang Zhen Zhang Jing Li Guangyong Qin New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition Toxins biocontrol bacterial toxins virulence probiotics medicinal plants |
| title | New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition |
| title_full | New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition |
| title_fullStr | New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition |
| title_full_unstemmed | New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition |
| title_short | New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition |
| title_sort | new strategies for biocontrol of bacterial toxins and virulence focusing on quorum sensing interference and biofilm inhibition |
| topic | biocontrol bacterial toxins virulence probiotics medicinal plants |
| url | https://www.mdpi.com/2072-6651/15/9/570 |
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