Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia
Preeclampsia (PE) is a severe complication of pregnancy. The identification of a reliable predictive biomarker could help in setting up a specific preventive strategy. To this aim, we studied carbonic anhydrase IX (CAIX) as a marker of hypoxia (a pathway involved in PE pathogenesis) and compared the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1075604/full |
| _version_ | 1797948253640065024 |
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| author | Silvia Galbiati Daniela Gabellini Alessandro Ambrosi Nadia Soriani Federica Pasi Massimo Locatelli Roberta Lucianò Massimo Candiani Luca Valsecchi Gianpaolo Zerbini Maddalena Smid |
| author_facet | Silvia Galbiati Daniela Gabellini Alessandro Ambrosi Nadia Soriani Federica Pasi Massimo Locatelli Roberta Lucianò Massimo Candiani Luca Valsecchi Gianpaolo Zerbini Maddalena Smid |
| author_sort | Silvia Galbiati |
| collection | DOAJ |
| description | Preeclampsia (PE) is a severe complication of pregnancy. The identification of a reliable predictive biomarker could help in setting up a specific preventive strategy. To this aim, we studied carbonic anhydrase IX (CAIX) as a marker of hypoxia (a pathway involved in PE pathogenesis) and compared the diagnostic accuracy of CAIX to that of the validated biomarker sFlt1/PlGF ratio. Fifteen women with overt PE and 38 women at a risk of developing PE, sampled at different time intervals during gestation (a total of 82 plasma samples collected), were enrolled and underwent the CAIX measurement. CAIX levels significantly increased (p < .001) before the onset of the disease in women (25% of the total number) who later on developed PE when compared to women who did not, starting from 28th gestational week. The best CAIX cut-off of 68.268 pg/mL yielded a sensitivity of 100%, a specificity of 81.82%, and an AUC value of .9221. In our pilot study, when compared to the sFlt1/PlGF ratio, CAIX performed better in predicting PE before the clinical onset. Furthermore when implemented as CAIX/PlGF ratio, showed up to be comparable in the identification of women with overt early PE. In conclusion, CAIX could represent an effective predictive biomarker of PE, and larger studies are mandatory to validate this finding. |
| first_indexed | 2024-04-10T21:40:28Z |
| format | Article |
| id | doaj.art-85aea934cb0c473ab29daf2fd86788aa |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-10T21:40:28Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-85aea934cb0c473ab29daf2fd86788aa2023-01-19T05:37:57ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-01-011010.3389/fmolb.2023.10756041075604Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsiaSilvia Galbiati0Daniela Gabellini1Alessandro Ambrosi2Nadia Soriani3Federica Pasi4Massimo Locatelli5Roberta Lucianò6Massimo Candiani7Luca Valsecchi8Gianpaolo Zerbini9Maddalena Smid10Complications of Diabetes Unit, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, ItalyComplications of Diabetes Unit, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, ItalySchool of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, ItalyUnit of Genomic for the Diagnosis of Human Pathologies, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, ItalyObstetrics and Gynecology Department, IRCCS San Raffaele Scientific Institute, Milan, ItalyLaboratory Medicine Service, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Pathology, IRCCS San Raffaele Hospital, Milan, ItalyObstetrics and Gynecology Department, IRCCS San Raffaele Scientific Institute, Milan, ItalyObstetrics and Gynecology Department, IRCCS San Raffaele Scientific Institute, Milan, ItalyComplications of Diabetes Unit, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, ItalyObstetrics and Gynecology Department, IRCCS San Raffaele Scientific Institute, Milan, ItalyPreeclampsia (PE) is a severe complication of pregnancy. The identification of a reliable predictive biomarker could help in setting up a specific preventive strategy. To this aim, we studied carbonic anhydrase IX (CAIX) as a marker of hypoxia (a pathway involved in PE pathogenesis) and compared the diagnostic accuracy of CAIX to that of the validated biomarker sFlt1/PlGF ratio. Fifteen women with overt PE and 38 women at a risk of developing PE, sampled at different time intervals during gestation (a total of 82 plasma samples collected), were enrolled and underwent the CAIX measurement. CAIX levels significantly increased (p < .001) before the onset of the disease in women (25% of the total number) who later on developed PE when compared to women who did not, starting from 28th gestational week. The best CAIX cut-off of 68.268 pg/mL yielded a sensitivity of 100%, a specificity of 81.82%, and an AUC value of .9221. In our pilot study, when compared to the sFlt1/PlGF ratio, CAIX performed better in predicting PE before the clinical onset. Furthermore when implemented as CAIX/PlGF ratio, showed up to be comparable in the identification of women with overt early PE. In conclusion, CAIX could represent an effective predictive biomarker of PE, and larger studies are mandatory to validate this finding.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1075604/fullCAIXbiomarkerhypoxiapregnancypreeclampsia |
| spellingShingle | Silvia Galbiati Daniela Gabellini Alessandro Ambrosi Nadia Soriani Federica Pasi Massimo Locatelli Roberta Lucianò Massimo Candiani Luca Valsecchi Gianpaolo Zerbini Maddalena Smid Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia Frontiers in Molecular Biosciences CAIX biomarker hypoxia pregnancy preeclampsia |
| title | Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia |
| title_full | Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia |
| title_fullStr | Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia |
| title_full_unstemmed | Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia |
| title_short | Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia |
| title_sort | early increase in circulating carbonic anhydrase ix a potential new predictive biomarker of preeclampsia |
| topic | CAIX biomarker hypoxia pregnancy preeclampsia |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1075604/full |
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