Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes
Chitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual acid neutralization should be performed for biomedical applications what may compromise physical and mechanical properties of the films. Thus, plasticizers can be added to improve these properties....
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2015-08-01
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| Series: | Materials Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/mr/v18n4/1516-1439-mr-18-4-781.pdf |
| _version_ | 1818743657198518272 |
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| author | Maria Gabriela Nogueira Campos Lucia Helena Innocentini Mei Arnaldo Rodrigues Santos Jr |
| author_facet | Maria Gabriela Nogueira Campos Lucia Helena Innocentini Mei Arnaldo Rodrigues Santos Jr |
| author_sort | Maria Gabriela Nogueira Campos |
| collection | DOAJ |
| description | Chitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual acid neutralization should be performed for biomedical applications what may compromise physical and mechanical properties of the films. Thus, plasticizers can be added to improve these properties. The aim of this study was to characterize morphological, barrier and mechanical properties, besides evaluate the in vitro cytotoxicity of sorbitol-plasticized and NaOH-Na2CO3 neutralized chitosan membranes for skin substitute application. Scanning electron microscopy, X-ray diffraction, water vapor permeability and mechanical tests were carried out to characterize the obtained membranes. Moreover, Vero cells were used for in vitro cytotoxicity evaluation. In this paper, we report a non-cytotoxic sorbitol-plasticized chitosan membrane with desirable properties for skin substitution, such as flexibility, water vapor permeability and high percentage of elongation. |
| first_indexed | 2024-12-18T02:31:53Z |
| format | Article |
| id | doaj.art-85b22fe8447f4822afc0aa764802a51a |
| institution | Directory Open Access Journal |
| issn | 1516-1439 |
| language | English |
| last_indexed | 2024-12-18T02:31:53Z |
| publishDate | 2015-08-01 |
| publisher | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
| record_format | Article |
| series | Materials Research |
| spelling | doaj.art-85b22fe8447f4822afc0aa764802a51a2022-12-21T21:23:52ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392015-08-0118478179010.1590/1516-1439.025015Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin SubstitutesMaria Gabriela Nogueira CamposLucia Helena Innocentini MeiArnaldo Rodrigues Santos JrChitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual acid neutralization should be performed for biomedical applications what may compromise physical and mechanical properties of the films. Thus, plasticizers can be added to improve these properties. The aim of this study was to characterize morphological, barrier and mechanical properties, besides evaluate the in vitro cytotoxicity of sorbitol-plasticized and NaOH-Na2CO3 neutralized chitosan membranes for skin substitute application. Scanning electron microscopy, X-ray diffraction, water vapor permeability and mechanical tests were carried out to characterize the obtained membranes. Moreover, Vero cells were used for in vitro cytotoxicity evaluation. In this paper, we report a non-cytotoxic sorbitol-plasticized chitosan membrane with desirable properties for skin substitution, such as flexibility, water vapor permeability and high percentage of elongation.http://www.scielo.br/pdf/mr/v18n4/1516-1439-mr-18-4-781.pdfchitosansorbitolskin substitutecytotoxicityVero cells |
| spellingShingle | Maria Gabriela Nogueira Campos Lucia Helena Innocentini Mei Arnaldo Rodrigues Santos Jr Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes Materials Research chitosan sorbitol skin substitute cytotoxicity Vero cells |
| title | Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes |
| title_full | Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes |
| title_fullStr | Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes |
| title_full_unstemmed | Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes |
| title_short | Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes |
| title_sort | sorbitol plasticized and neutralized chitosan membranes as skin substitutes |
| topic | chitosan sorbitol skin substitute cytotoxicity Vero cells |
| url | http://www.scielo.br/pdf/mr/v18n4/1516-1439-mr-18-4-781.pdf |
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