A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiog...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
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Nature Portfolio
2018-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03278-w |
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author | T. Azad H. J. Janse van Rensburg E. D. Lightbody B. Neveu A. Champagne A. Ghaffari V. R. Kay Y. Hao H. Shen B. Yeung B. A. Croy K. L. Guan F. Pouliot J. Zhang C. J. B. Nicol X. Yang |
author_facet | T. Azad H. J. Janse van Rensburg E. D. Lightbody B. Neveu A. Champagne A. Ghaffari V. R. Kay Y. Hao H. Shen B. Yeung B. A. Croy K. L. Guan F. Pouliot J. Zhang C. J. B. Nicol X. Yang |
author_sort | T. Azad |
collection | DOAJ |
description | The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis. |
first_indexed | 2024-12-18T04:19:30Z |
format | Article |
id | doaj.art-85b8748f8e55400f94efb6cc36e66651 |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-12-18T04:19:30Z |
publishDate | 2018-03-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-85b8748f8e55400f94efb6cc36e666512022-12-21T21:21:16ZengNature PortfolioNature Communications2041-17232018-03-019111510.1038/s41467-018-03278-wA LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesisT. Azad0H. J. Janse van Rensburg1E. D. Lightbody2B. Neveu3A. Champagne4A. Ghaffari5V. R. Kay6Y. Hao7H. Shen8B. Yeung9B. A. Croy10K. L. Guan11F. Pouliot12J. Zhang13C. J. B. Nicol14X. Yang15Department of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Surgery (Urology), CHU de Québec-Université Laval Research Center, Laval UniversityDepartment of Surgery (Urology), CHU de Québec-Université Laval Research Center, Laval UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Biomedical and Molecular Sciences, Queen’s UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Cancer Genetics and Genomics, Roswell Park Cancer InstituteDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Biomedical and Molecular Sciences, Queen’s UniversityDepartment of Pharmacology, University of California at San DiegoDepartment of Surgery (Urology), CHU de Québec-Université Laval Research Center, Laval UniversityDepartment of Cancer Genetics and Genomics, Roswell Park Cancer InstituteDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityThe Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis.https://doi.org/10.1038/s41467-018-03278-w |
spellingShingle | T. Azad H. J. Janse van Rensburg E. D. Lightbody B. Neveu A. Champagne A. Ghaffari V. R. Kay Y. Hao H. Shen B. Yeung B. A. Croy K. L. Guan F. Pouliot J. Zhang C. J. B. Nicol X. Yang A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis Nature Communications |
title | A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis |
title_full | A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis |
title_fullStr | A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis |
title_full_unstemmed | A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis |
title_short | A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis |
title_sort | lats biosensor screen identifies vegfr as a regulator of the hippo pathway in angiogenesis |
url | https://doi.org/10.1038/s41467-018-03278-w |
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