A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiog...

Full description

Bibliographic Details
Main Authors: T. Azad, H. J. Janse van Rensburg, E. D. Lightbody, B. Neveu, A. Champagne, A. Ghaffari, V. R. Kay, Y. Hao, H. Shen, B. Yeung, B. A. Croy, K. L. Guan, F. Pouliot, J. Zhang, C. J. B. Nicol, X. Yang
Format: Article
Language:English
Published: Nature Portfolio 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03278-w
_version_ 1818750427244527616
author T. Azad
H. J. Janse van Rensburg
E. D. Lightbody
B. Neveu
A. Champagne
A. Ghaffari
V. R. Kay
Y. Hao
H. Shen
B. Yeung
B. A. Croy
K. L. Guan
F. Pouliot
J. Zhang
C. J. B. Nicol
X. Yang
author_facet T. Azad
H. J. Janse van Rensburg
E. D. Lightbody
B. Neveu
A. Champagne
A. Ghaffari
V. R. Kay
Y. Hao
H. Shen
B. Yeung
B. A. Croy
K. L. Guan
F. Pouliot
J. Zhang
C. J. B. Nicol
X. Yang
author_sort T. Azad
collection DOAJ
description The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis.
first_indexed 2024-12-18T04:19:30Z
format Article
id doaj.art-85b8748f8e55400f94efb6cc36e66651
institution Directory Open Access Journal
issn 2041-1723
language English
last_indexed 2024-12-18T04:19:30Z
publishDate 2018-03-01
publisher Nature Portfolio
record_format Article
series Nature Communications
spelling doaj.art-85b8748f8e55400f94efb6cc36e666512022-12-21T21:21:16ZengNature PortfolioNature Communications2041-17232018-03-019111510.1038/s41467-018-03278-wA LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesisT. Azad0H. J. Janse van Rensburg1E. D. Lightbody2B. Neveu3A. Champagne4A. Ghaffari5V. R. Kay6Y. Hao7H. Shen8B. Yeung9B. A. Croy10K. L. Guan11F. Pouliot12J. Zhang13C. J. B. Nicol14X. Yang15Department of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Surgery (Urology), CHU de Québec-Université Laval Research Center, Laval UniversityDepartment of Surgery (Urology), CHU de Québec-Université Laval Research Center, Laval UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Biomedical and Molecular Sciences, Queen’s UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Cancer Genetics and Genomics, Roswell Park Cancer InstituteDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Biomedical and Molecular Sciences, Queen’s UniversityDepartment of Pharmacology, University of California at San DiegoDepartment of Surgery (Urology), CHU de Québec-Université Laval Research Center, Laval UniversityDepartment of Cancer Genetics and Genomics, Roswell Park Cancer InstituteDepartment of Pathology and Molecular Medicine, Queen’s UniversityDepartment of Pathology and Molecular Medicine, Queen’s UniversityThe Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis.https://doi.org/10.1038/s41467-018-03278-w
spellingShingle T. Azad
H. J. Janse van Rensburg
E. D. Lightbody
B. Neveu
A. Champagne
A. Ghaffari
V. R. Kay
Y. Hao
H. Shen
B. Yeung
B. A. Croy
K. L. Guan
F. Pouliot
J. Zhang
C. J. B. Nicol
X. Yang
A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
Nature Communications
title A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_full A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_fullStr A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_full_unstemmed A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_short A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_sort lats biosensor screen identifies vegfr as a regulator of the hippo pathway in angiogenesis
url https://doi.org/10.1038/s41467-018-03278-w
work_keys_str_mv AT tazad alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT hjjansevanrensburg alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT edlightbody alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT bneveu alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT achampagne alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT aghaffari alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT vrkay alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT yhao alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT hshen alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT byeung alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT bacroy alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT klguan alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT fpouliot alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT jzhang alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT cjbnicol alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT xyang alatsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT tazad latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT hjjansevanrensburg latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT edlightbody latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT bneveu latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT achampagne latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT aghaffari latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT vrkay latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT yhao latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT hshen latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT byeung latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT bacroy latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT klguan latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT fpouliot latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT jzhang latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT cjbnicol latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis
AT xyang latsbiosensorscreenidentifiesvegfrasaregulatorofthehippopathwayinangiogenesis