The role of B cell antigen receptors in mantle cell lymphoma
Abstract Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistance to currently available therapies in most cases. Therefore, despite recent advances in the treatment of this disease, it is still considered to be incurable in the majority of cases. MCL B c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13045-017-0533-9 |
| _version_ | 1818305327885451264 |
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| author | Michael Fichtner Martin Dreyling Mascha Binder Martin Trepel |
| author_facet | Michael Fichtner Martin Dreyling Mascha Binder Martin Trepel |
| author_sort | Michael Fichtner |
| collection | DOAJ |
| description | Abstract Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistance to currently available therapies in most cases. Therefore, despite recent advances in the treatment of this disease, it is still considered to be incurable in the majority of cases. MCL B cells retain their B cell antigen receptor (BCR) expression during and after neoplastic transformation. BCRs in MCL show distinct patterns of antigen selection and ongoing BCR signaling. However, little is known about the involved antigens and the mechanisms leading to lymphomagenesis and lymphoma progression in MCL. Recent preclinical and clinical studies have established a crucial role of the BCR and the potential of inhibiting its signaling in this disease. This has established the B cell antigen receptor signaling cascade as a very promising therapeutic target to improve outcome in MCL alone or in combination with chemo-immunotherapy in recent years. |
| first_indexed | 2024-12-13T06:24:50Z |
| format | Article |
| id | doaj.art-85b97cbbe5854968be63637e2371ac96 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-13T06:24:50Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-85b97cbbe5854968be63637e2371ac962022-12-21T23:56:46ZengBMCJournal of Hematology & Oncology1756-87222017-10-0110111210.1186/s13045-017-0533-9The role of B cell antigen receptors in mantle cell lymphomaMichael Fichtner0Martin Dreyling1Mascha Binder2Martin Trepel3Department of Physiology and Medical Physics, Royal College of Surgeons in IrelandDepartment of Medicine III, University Hospital LMU MunichDepartment of Oncology and Hematology, University Medical Center Hamburg-EppendorfDepartment of Oncology and Hematology, University Medical Center Hamburg-EppendorfAbstract Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistance to currently available therapies in most cases. Therefore, despite recent advances in the treatment of this disease, it is still considered to be incurable in the majority of cases. MCL B cells retain their B cell antigen receptor (BCR) expression during and after neoplastic transformation. BCRs in MCL show distinct patterns of antigen selection and ongoing BCR signaling. However, little is known about the involved antigens and the mechanisms leading to lymphomagenesis and lymphoma progression in MCL. Recent preclinical and clinical studies have established a crucial role of the BCR and the potential of inhibiting its signaling in this disease. This has established the B cell antigen receptor signaling cascade as a very promising therapeutic target to improve outcome in MCL alone or in combination with chemo-immunotherapy in recent years.http://link.springer.com/article/10.1186/s13045-017-0533-9B cell receptorMantle cell lymphomaSuperantigensLymphomagenesisB cell receptor inhibitors |
| spellingShingle | Michael Fichtner Martin Dreyling Mascha Binder Martin Trepel The role of B cell antigen receptors in mantle cell lymphoma Journal of Hematology & Oncology B cell receptor Mantle cell lymphoma Superantigens Lymphomagenesis B cell receptor inhibitors |
| title | The role of B cell antigen receptors in mantle cell lymphoma |
| title_full | The role of B cell antigen receptors in mantle cell lymphoma |
| title_fullStr | The role of B cell antigen receptors in mantle cell lymphoma |
| title_full_unstemmed | The role of B cell antigen receptors in mantle cell lymphoma |
| title_short | The role of B cell antigen receptors in mantle cell lymphoma |
| title_sort | role of b cell antigen receptors in mantle cell lymphoma |
| topic | B cell receptor Mantle cell lymphoma Superantigens Lymphomagenesis B cell receptor inhibitors |
| url | http://link.springer.com/article/10.1186/s13045-017-0533-9 |
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