Evaluation of a <sup>68</sup>Ga-Labeled DOTA-Tetrazine as a PET Alternative to <sup>111</sup>In-SPECT Pretargeted Imaging

Evaluation of a <sup>68</sup>Ga-Labeled DOTA-Tetrazine as a PET Alternative to <sup>111</sup>In-SPECT Pretargeted Imaging

The bioorthogonal reaction between a tetrazine and strained trans-cyclooctene (TCO) has garnered success in pretargeted imaging. This reaction was first validated in nuclear imaging using an <sup>111</sup>In-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-linked b...

Full description

Bibliographic Details
Main Authors:	Patricia E. Edem, Jesper T. Jørgensen, Kamilla Nørregaard, Rafaella Rossin, Abdolreza Yazdani, John F. Valliant, Marc Robillard, Matthias M. Herth, Andreas Kjaer
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	Molecules
Subjects:	tetrazine ligation pet spect gallium-68 indium-11
Online Access:	https://www.mdpi.com/1420-3049/25/3/463

Similar Items

Development of <sup>18</sup>F-Labeled Bispyridyl Tetrazines for In Vivo Pretargeted PET Imaging
by: Rocío García-Vázquez, et al.
Published: (2022-02-01)

Evaluation of [<sup>64</sup>Cu]Cu-NOTA-PEG<sub>7</sub>-H-Tz for Pretargeted Imaging in LS174T Xenografts—Comparison to [<sup>111</sup>In]In-DOTA-PEG<sub>11</sub>-BisPy-Tz
by: Christian B. M. Poulie, et al.
Published: (2021-01-01)

Optimization of Direct Aromatic <sup>18</sup>F-Labeling of Tetrazines
by: Ida Vang Andersen, et al.
Published: (2022-06-01)

Recent Advances in the Development of Tetrazine Ligation Tools for Pretargeted Nuclear Imaging
by: Rocío García-Vázquez, et al.
Published: (2022-05-01)

Preclinical Evaluation of a New Format of <sup>68</sup>Ga- and <sup>111</sup>In-Labeled Affibody Molecule Z<sub>IGF-1R:4551</sub> for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT
by: Yongsheng Liu, et al.
Published: (2022-07-01)

Clearing and Masking Agents in Pretargeting Strategies
by: Markus Staudt, et al.
Published: (2023-03-01)

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging
by: Patricia E. Edem, et al.
Published: (2019-05-01)

Evaluation of Organo [<sup>18</sup>F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers
by: Sofia Otaru, et al.
Published: (2020-03-01)

Development of a multi faceted platform containing a tetrazine, fluorophore and chelator: synthesis, characterization, radiolabeling, and immuno-SPECT imaging
by: Anthony W. McDonagh, et al.
Published: (2022-06-01)

Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation
by: Jiayu Sun, et al.
Published: (2021-01-01)

Correlations between [<sup>68</sup>Ga]Ga-DOTA-TOC Uptake and Absorbed Dose from [<sup>177</sup>Lu]Lu-DOTA-TATE
by: Ragnar Bruvoll, et al.
Published: (2023-02-01)

Preparation and Evaluation of [<sup>18</sup>F]AlF-NOTA-NOC for PET Imaging of Neuroendocrine Tumors: Comparison to [<sup>68</sup>Ga]Ga-DOTA/NOTA-NOC
by: Johan Hygum Dam, et al.
Published: (2022-10-01)

Effect of Post-Annealing on Barrier Modulations in Pd/IGZO/SiO<sub>2</sub>/p<sup>+</sup>-Si Memristors
by: Donguk Kim, et al.
Published: (2022-10-01)

Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models
by: Outi Keinänen, et al.
Published: (2017-12-01)

A Review on the Current State and Future Perspectives of [<sup>99m</sup>Tc]Tc-Housed PSMA-i in Prostate Cancer
by: Sara Brunello, et al.
Published: (2022-04-01)

Radioactive Labeling of Milk-Derived Exosomes with <sup>99m</sup>Tc and In Vivo Tracking by SPECT Imaging
by: María Isabel González, et al.
Published: (2020-05-01)

Antibody-Based In Vivo Imaging of Central Nervous System Targets—Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines
by: Christoph Bredack, et al.
Published: (2022-11-01)

Tetrazine bioorthogonal chemistry derived in vivo imaging
by: Gaoxiang Zhao, et al.
Published: (2022-11-01)

Recent Advances in <sup>64</sup>Cu/<sup>67</sup>Cu-Based Radiopharmaceuticals
by: Olga O. Krasnovskaya, et al.
Published: (2023-05-01)

Prospective SPECT-CT Organ Dosimetry-Driven Radiation-Absorbed Dose Escalation Using the In-111 (<sup>111</sup>In)/Yttrium 90 (<sup>90</sup>Y) Ibritumomab Tiuxetan (Zevalin<sup>®</sup>) Theranostic Pair in Patients with Lymphoma at Myeloablative Dose Levels
by: Richard L. Wahl, et al.
Published: (2021-06-01)

Development of Novel <sup>111</sup>-In-Labelled DOTA Urotensin II Analogues for Targeting the UT Receptor Overexpressed in Solid Tumours
by: Benjamin Poret, et al.
Published: (2020-03-01)

Diagnostic Performance of <sup>99m</sup>Tc-iPSMA SPECT/CT in the Initial Staging of Patients with Unfavorable Intermediate-, High-, and Very High-Risk Prostate Cancer: A Comparative Analysis with <sup>18</sup>F-PSMA-1007 PET/CT
by: Joel E. Vargas-Ahumada, et al.
Published: (2023-12-01)

Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
by: Yayue Wang, et al.
Published: (2020-11-01)

Myocardial perfusion imaging with <sup>99 m</sup>Tc - tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: a case-control study
by: Sioka Chrissa, et al.
Published: (2011-11-01)

The Role of [<sup>68</sup>Ga]Ga-DOTA-SSTR PET Radiotracers in Brain Tumors: A Systematic Review of the Literature and Ongoing Clinical Trials
by: Paolo Palmisciano, et al.
Published: (2022-06-01)

<sup>99m</sup>Tc-Labeled FAPI SPECT Imaging in Idiopathic Pulmonary Fibrosis: Preliminary Results
by: Yu Liu, et al.
Published: (2023-10-01)

Assessment of Motor Dysfunction with Virtual Reality in Patients Undergoing [<sup>123</sup>I]FP-CIT SPECT/CT Brain Imaging
by: Jeanne P. Vu, et al.
Published: (2021-03-01)

<sup>11</sup>C-Choline PET/CT vs. <sup>99m</sup>Tc-MIBI/<sup>123</sup>Iodide Subtraction SPECT/CT for Preoperative Detection of Abnormal Parathyroid Glands in Primary Hyperparathyroidism: A Prospective, Single-Centre Clinical Trial in 60 Patients
by: Afefah Ismail, et al.
Published: (2020-11-01)

Overview of Syntheses and Molecular-Design Strategies for Tetrazine-Based Fluorogenic Probes
by: Sang-Kee Choi, et al.
Published: (2021-03-01)

The Pseudo-Protic Ionic Liquids TOAH<sup>+</sup>Cl<sup>−</sup> and TODAH<sup>+</sup>Cl<sup>−</sup> as Carriers for Facilitated Transport of In(III) from HCl Solutions
by: Francisco José Alguacil, et al.
Published: (2022-12-01)

Synthesis of Novel Triazoles, Tetrazine, Thiadiazoles and Their Biological Activities
by: Mohammed A. Al-Omair, et al.
Published: (2015-02-01)

Molecular Imaging with <sup>18</sup>F-FDG PET/CT and <sup>99m</sup>Tc-MIBI SPECT/CT in Osteitis Fibrosa Cystica Generalisata
by: Adrien Holzgreve, et al.
Published: (2021-07-01)

<sup>68</sup>Ga-Labeled [Leu<sup>13</sup>ψThz<sup>14</sup>]Bombesin(7–14) Derivatives: Promising GRPR-Targeting PET Tracers with Low Pancreas Uptake
by: Lei Wang, et al.
Published: (2022-06-01)

Classification of the Multiple Stages of Parkinson’s Disease by a Deep Convolution Neural Network Based on <sup>99m</sup>Tc-TRODAT-1 SPECT Images
by: Shih-Yen Hsu, et al.
Published: (2020-10-01)

Preclinical Evaluation of [<sup>155/161</sup>Tb]Tb-Crown-TATE—A Novel SPECT Imaging Theranostic Agent Targeting Neuroendocrine Tumours
by: Luke Wharton, et al.
Published: (2023-04-01)

Cost-Effectiveness Analysis of <sup>68</sup>Ga DOTA-TATE PET/CT, <sup>111</sup>In-Pentetreotide SPECT/CT and CT for Diagnostic Workup of Neuroendocrine Tumors
by: Matthias Frank Froelich, et al.
Published: (2021-02-01)

Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with <sup>68</sup>Ga and <sup>177</sup>Lu as Potential Theranostic Agents
by: Evangelia-Alexandra Salvanou, et al.
Published: (2022-07-01)

Radionuclide Cisternography with [<sup>64</sup>Cu]Cu-DOTA
by: Julia Greiser, et al.
Published: (2023-09-01)

Automated GMP Production and Preclinical Evaluation of [<sup>68</sup>Ga]Ga-TEoS-DAZA and [<sup>68</sup>Ga]Ga-TMoS-DAZA
by: Julia Greiser, et al.
Published: (2022-12-01)

Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
by: Przemysław Koźmiński, et al.
Published: (2021-12-01)