Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents
The present study describes DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity and antimutagenic properties of the essential oil of myrtle (Myrtus communis L.). Plant samples were collected from the two distant localities (southernmost and northern point) of the Montenegro coastline. C...
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MDPI AG
2010-04-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/4/2759/ |
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| author | Neda Mimica-Dukić Dušan Bugarin Slavenko Grbović Dragana Mitić-Ćulafić Branka Vuković-Gačić Dejan Orčić Emilija Jovin Maria Couladis |
| author_facet | Neda Mimica-Dukić Dušan Bugarin Slavenko Grbović Dragana Mitić-Ćulafić Branka Vuković-Gačić Dejan Orčić Emilija Jovin Maria Couladis |
| author_sort | Neda Mimica-Dukić |
| collection | DOAJ |
| description | The present study describes DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity and antimutagenic properties of the essential oil of myrtle (Myrtus communis L.). Plant samples were collected from the two distant localities (southernmost and northern point) of the Montenegro coastline. Chemical profiles of the two samples were evaluated by GC-MS. In both of the samples monoterpenes were found to be the predominant compounds. Among them a-pinene, linalool, 1,8-cineole, and myrtenyl acetate were the major compounds. Significant differences between the samples were found in the ranges of a-pinene (14.7%–35.9%) and myrtenyl acetate (5.4%–21.6%). Both oils exhibited moderate DPPH scavenging activity, with IC50 values of 6.24 mg/mL and 5.99 mg/mL. The antimutagenic properties were assayed against spontaneous and t-BOOH-induced mutagenesis in Escherichia coli oxyR mutant IC202, a bacterial strain deficient in removing ROS. Reduction of the spontaneous mutagenesis in presence of myrtle EO was only slight, up to 13% at the highest concentration tested. When the oxidative mutagen was used, EO expressed higher reduction of mutagenesis, in a concentration dependent manner, with statistical significance for effect at the highest concentration tested (28%). Suppression of t-BOOH induced mutagenesis was correlated with the observed scavenging activity. |
| first_indexed | 2024-12-18T23:42:59Z |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T23:42:59Z |
| publishDate | 2010-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-85bab6e194104f1bbefe746f6eebbeee2022-12-21T20:47:19ZengMDPI AGMolecules1420-30492010-04-011542759277010.3390/molecules15042759Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic AgentsNeda Mimica-DukićDušan BugarinSlavenko GrbovićDragana Mitić-ĆulafićBranka Vuković-GačićDejan OrčićEmilija JovinMaria CouladisThe present study describes DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity and antimutagenic properties of the essential oil of myrtle (Myrtus communis L.). Plant samples were collected from the two distant localities (southernmost and northern point) of the Montenegro coastline. Chemical profiles of the two samples were evaluated by GC-MS. In both of the samples monoterpenes were found to be the predominant compounds. Among them a-pinene, linalool, 1,8-cineole, and myrtenyl acetate were the major compounds. Significant differences between the samples were found in the ranges of a-pinene (14.7%–35.9%) and myrtenyl acetate (5.4%–21.6%). Both oils exhibited moderate DPPH scavenging activity, with IC50 values of 6.24 mg/mL and 5.99 mg/mL. The antimutagenic properties were assayed against spontaneous and t-BOOH-induced mutagenesis in Escherichia coli oxyR mutant IC202, a bacterial strain deficient in removing ROS. Reduction of the spontaneous mutagenesis in presence of myrtle EO was only slight, up to 13% at the highest concentration tested. When the oxidative mutagen was used, EO expressed higher reduction of mutagenesis, in a concentration dependent manner, with statistical significance for effect at the highest concentration tested (28%). Suppression of t-BOOH induced mutagenesis was correlated with the observed scavenging activity.http://www.mdpi.com/1420-3049/15/4/2759/Myrtus communis L.essential oila-pinene1,8-cineolemyrtenyl acetatemutagenesisDPPH test |
| spellingShingle | Neda Mimica-Dukić Dušan Bugarin Slavenko Grbović Dragana Mitić-Ćulafić Branka Vuković-Gačić Dejan Orčić Emilija Jovin Maria Couladis Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents Molecules Myrtus communis L. essential oil a-pinene 1,8-cineole myrtenyl acetate mutagenesis DPPH test |
| title | Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents |
| title_full | Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents |
| title_fullStr | Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents |
| title_full_unstemmed | Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents |
| title_short | Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents |
| title_sort | essential oil of myrtus communis l as a potential antioxidant and antimutagenic agents |
| topic | Myrtus communis L. essential oil a-pinene 1,8-cineole myrtenyl acetate mutagenesis DPPH test |
| url | http://www.mdpi.com/1420-3049/15/4/2759/ |
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